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Biomedical subjects

B Toth

Publications and source records attributed to B Toth.

At least 127 records · Page 7Linked to original sources
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Effects of lifelong administration of beta-phenylisopropylhydrazine hydrochloride and thiocarbamylhydrazine in mice.

beta-Phenylisopropylhydrazine hydrochloride and thiocarbamylhydrazine were separately administered as 0.0312 and 0.0156% solutions in drinking water for life to randomly bred Swiss mice. The consumption of the chemicals resulted in no detectable tumorigenic effects in the treated animals, and it is therefore concluded that these compounds are apparently noncarcinogenic under the present experimental conditions.

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PubMedDate not supplied

Hepatocarcinogenesis by hydrazine mycotoxins of edible mushrooms.

Two edible mushrooms are known to contain hydrazine analogs. The wild false morel Gyromitra esculenta contains up to 0.3% acetaldehyde methylformylhydrazone and N-methyl-N-formylhydrazine (MFH). The latter chemical, under certain conditions, also yields methylhydrazine. The commonly eaten, cultivated mushroom Agaricus bisporus contains up to 0.04% beta-N-[gamma-L(+)-glutamyl]-4-hydroxymethylphenylhydrazine and 4-hydroxymethylphenylhydrazine. MFH was administered in drinking water continuously for life to Swiss mice and Syrian (golden) hamsters. In both species the compound induced high incidences of benign and malignant hepatocellular neoplasms. Also, methylhydrazine given orally induced a significant incidence of malignant histiocytomas in the livers of hamsters. The N'-acetyl derivative of 4-hydroxymethylphenylhydrazine administered orally to mice gave rise to lung tumors and blood vessel tumors, mainly in the liver. Furthermore, these three compounds produced tumors in various other tissues. Histopathologically, the tumors were classified as benign hepatomas, liver cell carcinomas, angiomas and angiosarcomas of blood vessels, and adenomas and adenocarcinomas of lungs. From representative samples of these neoplasms detailed transmission electron microscopic investigations were also carried out. Since these hydrazine analogs induce tumors in animals and these mushrooms are consumed on a large scale by humans in various parts of the world, their hazardous nature should be considered.

Animals↗
PubMedDate not supplied

Studies of the tumorigenic potential of 4-substituted phenylhydrazines by the subcutaneous route.

4-Methylphenylhydrazine hydrochloride (4-MPH) was administered to randomly bred Swiss mice as 26 weekly sc injections of 140 microgram per gram of body weight and N'-acetyl-4-(hydroxymethyl)phenylhydrazine (AMPH) as 26 weekly sc injections of 500 microgram/g. As a solvent control, physiological saline was also given as 26 weekly sc injections of 0.01 ml/g. The 4-MPH treatment induced a significant incidence (24%) of fibrosarcomas in males. In the 4-MPH-treated females and some AMPH-treated male mice, a few soft-tissue tumors were observed; however, their appearance could not be related to treatment. 4-MPH is formed under special experimental conditions from 4-hydroxymethylphenyl-hydrazine, which is an in vitro breakdown product of agaritine, an ingredient of the cultivated mushroom Agaricus bisporus. The implications of the findings are discussed.

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