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Biomedical subjects

B Stone

Publications and source records attributed to B Stone.

69 records · Page 4Linked to original sources
PubMed1978

An assessment of hospital care for the alcoholic patient.

Current medical practice, vis-à-vis chemical dependency, was assessed in a university hospital setting. Findings indicate that the majority of physicians and nurses at this facility (1) did not take adequate alcohol and drug use histories, (2) did not identify chemical dependency as a medical problem even when they knew dependency was present, and (3) did not involve themselves in treatment or treatment recommendations even when the problem was identified.

Adolescent↗
PubMed1975

School phobia and other childhood neuroses: a systematic study of the children and their families.

The authors developed reliable clinical rating scales to compare 35 children with school phobia and their families with a matched sample of children with other neuroses and their families. Twice as many school phobic children as children with other neuroses showed excessive separation anxiety, dependency, and depression. Although a mutually hostile-dependent interaction was found in most of the families of children with school phobia, the development of school phobia appeared to be dependent on defects in character development in the children as well. The authors discuss the etiological significance of the almost universal parental pathology and family malfunction for both groups of children.

Aggression↗
PubMedDate not supplied

Symbolic, neural, and Bayesian machine learning models for predicting carcinogenicity of chemical compounds.

Experimental programs have been underway for several years to determine the environmental effects of chemical compounds, mixtures, and the like. Among these programs is the National Toxicology Program (NTP) on rodent carcinogenicity. Because these experiments are costly and time-consuming, the rate at which test articles (i.e., chemicals) can be tested is limited. The ability to predict the outcome of the analysis at various points in the process would facilitate informed decisions about the allocation of testing resources. To assist human experts in organizing an empirical testing regime, and to try to shed light on mechanisms of toxicity, we constructed toxicity models using various machine learning and data mining methods, both existing and those of our own devising. These models took the form of decision trees, rule sets, neural networks, rules extracted from trained neural networks, and Bayesian classifiers. As a training set, we used recent results from rodent carcinogenicity bioassays conducted by the NTP on 226 test articles. We performed 10-way cross-validation on each of our models to approximate their expected error rates on unseen data. The data set consists of physical-chemical parameters of test articles, alerting chemical substructures, salmonella mutagenicity assay results, subchronic histopathology data, and information on route, strain, and sex/species for 744 individual experiments. These results contribute to the ongoing process of evaluating and interpreting the data collected from chemical toxicity studies.

Animals↗
PubMedDate not supplied

Spontaneous cerebrospinal fluid rhinorrhea with associated sinusitis and allergic rhinitis.

The entity of spontaneous cerebrospinal fluid rhinorrhea is a rare condition that presents a special challenge to the practicing allergist. Delayed diagnosis can be associated with significant morbidity and mortality. We describe two cases of this condition occurring in association with allergic rhinitis and sinusitis. The presentation and management of these cases is described. A high index of suspicion for this condition should be maintained in all patients who present with profuse and often unilateral rhinorrhea.

Cerebrospinal Fluid Rhinorrhea↗
PubMedDate not supplied

Alcoholism indicators: nonreliability of events partially related to alcohol abuse.

Certain events partially associated with alcohol abuse (e.g., all hepatic cirrhosis) as well as those wholly associated with alcohol abuse (e.g., alcoholic cirrhosis) have been used to assess changes in alcoholism rates over time. In this paper, events partially associated with alcohol abuse are compared with events wholly correlated with alcohol abuse. Location and time of the study was the state of Minnesota from 1965 to 1977. Taken as a whole, the partially related events fail to show an increase in alcoholism while the wholly related events point to an increase. The literature on these alcohol-related events is reviewed, and theories for the discrepancies between partially and wholly related events are offered.

Accidents↗