Search PubMed⌕ Search

Biomedical subjects

B Sommer

Publications and source records attributed to B Sommer.

At least 145 records · Page 8Linked to original sources
PubMed1984

[The joints in the posterior part of the foot in the computed tomogram. Studies on amputation preparations and clinical observations].

CT of the foot often helps clarification of difficult problems where conventional radiology has proved inadequate. Sections in the coronary and transverse plane may demonstrate fractures, joint involvement and displacement of bone fragments. Ill-defined degenerative changes in the talo-calcaneal joint can be demonstrated. The extent and localisation of rare tumours of the foot can be shown and additional information may be obtained by densitometric studies.

Adolescent↗
PubMed1984

Ketoconazole--an effective treatment for disseminated pityriasis versicolor.

Long-standing disseminated lesions of pityriasis versicolor (PV) were found in 101 patients. As they had failed to respond to various topical agents, we treated them with 200 mg/day of ketoconazole. All of them were under clinical and mycological surveillance at weekly intervals. In successive mycological examinations during the course of therapy, an increased ratio of filaments/spores was observed, and the last positive examinations invariably showed the presence of only a few filaments and no spores. The mean duration of therapy, until a negative mycological smear was obtained, was 2.2 weeks. Side effects were insignificant, and did not necessitate interrupting treatment except in one patient, who developed an allergic eruption after a single 200-mg dose of the drug. The transient minor disturbances in liver function tests noted in six patients were considered drug related, but ketoconazole administration was continued in all these patients, and the values normalized gradually during treatment. We conclude that ketoconazole is a well-tolerated and highly effective drug in the systemic therapy of disseminated PV.

Administration, Oral↗
PubMed1984

Treatment of acute asthma in children with rectal administration of aminophylline solution.

In a double-blind cross-over study, 20 children suffering from acute bronchoconstriction were treated with an interval of 90 min with placebo and 9.0 mg theophylline per kg given rectally in aqueous solution. Each child took part on 2 occasions. Fifteen min after both administrations of theophylline there was a significant increase in peak flow (PEF) as compared with placebo treatment (p less than 0.05). The increase in PEF was related to the serum level of theophylline, a significant bronchodilating effect was observed at about 7 mg/l. Substantial inter- and intrapatient variations were found in the improvement of PEF. The absorption of theophylline was rapid. The measured peak serum levels varied from 7.3 to 16.0 mg/l and occurred within 60 min in most patients. The intra-subject variations in the dose-to-dose absorption profiles were generally small and within a range acceptable for clinical use. The solutions allowed an accurate dosage calculation, did not initiate the urge to defecate, and were retained well.

Acute Disease↗
PubMed1982

Circadian changes in the destruction and effects of haloperidol in the rat.

Striking circadian changes in behavioral sensitivity to haloperidol were found by measurements of cataleptic responses in rats trained in a controlled lighting cycle (lights on, 7:00 a.m.--7:00 p.m.). Thus, catalepsy was maximal at about 4:00 p.m. and minimal at about 4:00 a.m., virtually the opposite of the circadian rhythm of spontaneous behavioral activity in drug-free rats. At a given dose of haloperidol, catalepsy scores differed 2- to 3-fold, and the ED50 shifted left nearly 10-fold from a.m. to p.m. After fixed doses of haloperidol, tissue levels of the drug, as determined by a sensitive and selective radioreceptor assay, differed by 2- to 6-fold through the 24 hr cycle and brain levels closely followed the circadian changes in behavior. These results suggest a pharmacokinetic contribution to the circadian changes in behavioral response, although additional pharmacodynamic factors are also considered.

Animals↗
PubMed1982

[Preoperative localization of the parathyroid glands with computerized tomography].

CT was carried out in 50 patients with clinical suspicion of hyperparathyroidism, in order to localise the adenoma. In 45 patients, the diagnosis was confirmed at operation and adenomas or hyperplastic glands were removed. In the remaining five patients the diagnosis was not confirmed at operation, nor by the subsequent clinical course. On four occasions, CT correctly turned out to be negative and in one patient a false positive finding was obtained. Amongst the 45 patients, a total of 59 enlarged glands (adenomas or hyperplastic glands) were found at operation and removed. Pre-operative CT was positive and correct in 78% and negative and incorrect in 22%. Of eight adenomas in the mediastinum, seven could be recognised pre-operatively. Previous operations on the neck did not reduce diagnostic accuracy. The techniques and results are described and discussed.

Adenoma↗
PubMed1982

Computed tomography for localizing enlarged parathyroid glands in primary hyperparathyroidism.

Computed tomography (CT) has been performed in 21 patients with primary hyperparathyroidism (HPT) in an attempt to localize preoperatively the parathyroid tumors. Eighteen of these patients also had ultrasound examinations. The CT examinations included the neck and mediastinum and were performed before and after contrast medium administration. At subsequent surgery, 24 enlarged glands were found, 20 in the neck and 4 in the mediastinum. In the neck, two were locally recurrent carcinomas. The true positive diagnostic rate for ultrasound was 60% with a false positive rate of 15% and a false negative rate of 25%. The CT examinations resulted in 70.9% true positive, 8.3% false positive, and 20.8% false negative diagnoses. The combination of both methods in the 18 patients so studied resulted in 80% true positive, 10% false positive, and 10% false negative findings. The CT examination procedure and its interpretation and limitations in primary HPT are described.

Adenoma↗
PubMed1982

Indication for, and valuation of computed tomography following anterior resection of the rectum.

During a controlled study, 55 patients who had an anterior resection of the rectum were thoroughly examined, including by computed tomography. The results verified the following statements: 1. The use of CT as a screening-method for early detection of local tumour recurrence following anterior resection of the rectum appears not to be justified. 2. CT is indicated: a) if there is a laboratory or clinical suspicion of recurrence, despite normal findings on proctoscopy; b) to clarify the question of extramural extension if recurrence has been established by proctoscopy. 3. Following anterior resection of the rectum, CT normally demonstrates no remarkable development of scar tissue, unless the anastomosis is inadequate. 4. Following anterior rectal resection every indefinable tissue thickening in the pelvis must be considered a possible tumour recurrence and must be further investigated by needle biopsy.

Carcinoma↗
PubMed1981

Job stress and health in working women.

A questionnaire assessing subjective level of job stress and physical health over the past two years was completed by 173 women in university (non-faculty) positions. Health was divided into two categories: menstrual dysfunction and other non-menstrual symptoms. Two samples, matched for age, were selected: women in high-paying positions (N = 72) and women in low-paying positions (N = 101). Respondents also answered a Recent Life Changes Questionnaire (RLCQ) and an eight-item life satisfaction list. The hypothesis of a positive relationship between job stress and menstrual dysfunction was rejected. The predicted relationship held for non-menstrual symptoms. Subjective stress, RLCQ score, and life satisfaction accounted for 21% of the variance in non-menstrual symptoms. Thus, while both RLCQ and subjective job stress were related to symptom reports, their contributions were independent of one another. The female reproductive system does not seem particularly vulnerable to the levels of stress experienced in professional, managerial, and clerical occupations.

Employment↗