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Biomedical subjects

B Singh

Publications and source records attributed to B Singh.

At least 883 records · Page 49Linked to original sources
PubMed1978

Leiomyosarcoma of paranasal sinuses.

A leiomyosarcoma of the upper respiratory and food passages is a rarity. Two rare cases of leiomyosarcoma of the paranasal sinuses, of which one developed recurrence are reported.

Adult↗
PubMed1978

Cutaneous horn.

Cutaneous horn or sebaceous horn is an extremely rare clinical entity. A case of cutaneous horn of the cheek presenting in a middle aged female is reported. It was successfully treated by surgical excision.

Cheek↗
PubMed1978

A fatal denture in the oesophagus.

An unusual case is described of a denture in the oesophagus which caused a fatal haemorrhage from the aorta. The post-mortem examination confirmed that a projection from the denture had impinged upon the aortic wall, after perforating the oesophagus, with subsequent erosion of the aorta.

Aorta, Thoracic↗
PubMed1978

A quantitative clinical comparison of three 99mTechnetium labeled brain imaging radiopharmaceuticals.

In a comparison study of three commonly employed 99mTc brain imaging pharmaceuticals, 16 patients with proven brain lesions had imaging performed with DTPA, glucoheptonate, and pertechnetate over a short interval of time. Lesion detectability was assessed by a data processing system which evaluated average lesion-to-background activity ratios for each patient examination. Statistical analysis of the resultant data demonstrated a significant improvement (20%) in lesion-to-background ratio in favor of one hour delayed DTPA images versus two hour delayed pertechnetate images. Comparison of one hour delayed DTPA images with one hour delayed glucoheptonate images did not reveal a significant difference in lesion-to-background ratio. The authors conclude that both Tc-DTPA and Tc-glucoheptonate are superior alternatives to pertechnetate when employed in the manner described.

Brain↗
PubMed1978

Intimal changes in the coronary arteries of Indian water buffaloes (Bubalus bubalis).

Of 75 Indian water buffaloes (Bubalus bubalis) examined, 14 6-year-old or older buffaloes had early atherosclerotic lesions in the coronary arteries. These lesions resembled fatty streaks seen in man. Ageing changes and gross and microscopic features of the fatty streaks in the vessels resembled those described in the corresponding arteries of man.

Animals↗
PubMed1978

Conversion reactions simulating Guillain-Barré paralysis following suspension of the swine flu vaccination program in the U.S.A.

The association of Guillain-Barré Syndrome as a possible complication of swine flu inoculation created the potential for conversion reactions simulating this syndrome. Upon termination of the swine flu vaccination program, a study was initiated in a prepaid health plan to identify and categorize such patients. An estimated 8000 adults were vaccinated and it was hypothesized that a large number of these patients would present to the health plan with conversion symptoms. However, only seven patients met the criteria and they were compared to two control groups (inoculated and uninoculated). The patients with conversion symptoms did show similatities to those previously described in the literature: all were female, of lower educational level, and had great concern with health problems. Other speculations as to why these patients had conversion reactions were made.

Adult↗
PubMed1978

[Isatin-enzyme interactions. VI. Inhibition of rat kidney alkaline phosphatase].

Interaction of isatin with rat kidney alkaline phosphatase has been studied. Mode of attachment of isatin with the enzyme protein is most likely through amino group(s), which is also imperative for catalysis. Sulphydryl group(s) do not seem to be involved in enzyme action. Zinc is also needed for enzyme activity. Use of sulphydryl compounds suggests that isatin inhibition of the enzyme is through attachment at the metal site. However, this inhibition may not only be due to simple chelation of the metal by isatin.

Alkaline Phosphatase↗
PubMed1978

Characterization and genetic control of the immune response to synthetic polypeptide antigens of defined geometry.

Both humoral and cell-mediated immune responses to the synthetic helical hapten-carrier conjugate poly-Glu-Tyr-Lys(TNP)-(Glu-Tyr-Ala)5 were found to be linked to the major histocompatibility locus in mice and guinea pigs. The responder mouse strains (H-2d haplotype) showed a primary IgM response with an IgG component appearing after the secondary immunization. The antibody response was accompanied by a positive DTH reaction in responder strains. Nonresponder mice (H-2b or H-2k haplotypes) showed neither IgM nor IgG antibodies and the DTH reaction was negative. Administration of the antigen as a complex with an immunogenic carrier was not effective in inducing a response in nonresponder mice. In guinea pig studies, it was found that strain 2 animals were able to mount an antibody response against the TNP-hapten and a DTH response against the polypeptide backbone. Strain 13 animals gave no anti-TNP antibodies at the lower dose levels and DTH activity was entirely negative for all doses of immunizing antigen. Replacement of the TNP hapten by the arsanilazo dipeptide derivative, BOC-gly-ARA-tyrosine, converted the nonresponder strain 13 guinea pigs into complete responders showing antibody and DTH reactions to both the hapten and the polypeptide backbone.

Animals↗
PubMed1977

Carbon dioxide sensitivity of the central chemosensitive mechanisms. An exploration by direct stimulation in rats.

In urethane-anaesthetised adult albino rats ventral surface of the brainstem was stimulated chemically by increasing the local CO2 concentration and electrically. Two areas were demarcated on the ventral surface of the brainstem, one which showed an increase in pulmonary ventilation on chemical and electrical stimulation, and another which showed a decrease in pulmonary ventilation and sometimes even respiratory arrest. EEG activity recorded from the area from where increased pulmonary ventilation was obtained showed a synchronous slow wave activity during chemical stimulation and inhalation of a CO2-air mixture. This area is situated 0.5--1 mm lateral to the mid-line extending up to the rootlets of the VIIth to IXth cranial nerves. The response increased proportionately on increasing the strength of the chemical stimulus, till it reached a plateau. In carotid body denervated and chronic hypoxic animals, the magnitude of the responses was shown to be increased, probably due to increased sensitivity of the central chemosensitive mechanisms.

Animals↗