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Biomedical subjects

B Sinclair

Publications and source records attributed to B Sinclair.

25 records · Page 2Linked to original sources
PubMed1989

Generalized cortical dysplasia manifested by diffusely thick cerebral cortex.

Unilateral or bilateral rolandic macrogyria has been described as a cause of epilepsy and, in some cases, retardation. Tissue from the periphery of these lesions shows the changes of focal cortical dysplasia. Evidence reported herein suggests that cortical dysplasia may also be generalized. Two patients with intractable epilepsy and mental retardation had diffusely abnormal, thick cortex, shallow gyri, and poor demarcation of gray and white matter. One patient had an anterior callosotomy that led to considerable improvement of the epilepsy. Cortical layers 5 and 6 could not be differentiated on biopsy material. The white matter was poorly myelinated and contained clusters of heterotopic neurons. This syndrome, a congenital disorder of neuronal migration, with prolonged survival, represents a mild form of lissencephaly. It can be diagnosed during life by computed tomography or magnetic resonance scanning.

Adolescent↗
PubMed1988

Surface modeling of craniofacial form in human embryos with a limited graphics terminal.

Three-dimensional morphology of the human embryo typically is visualized through computerized modeling techniques utilizing planar contours as the data base. Through this approach, tissue outlines are digitized, and contour lines are superimposed, providing a depth perspective. However, these techniques represent embryonic tissues as discontinuous surfaces and therefore ignore morphological information between sections. The purpose of this study was to develop a computerized routine for the three-dimensional surface modeling of craniofacial morphology in human embryos. Tissue outlines are digitized, thus converting contour information into x,y,z coordinate data. The three-dimensional reconstruction program BCSURF opens the data file and plots each tissue polygon. A center is determined for each contour, and this value is used to divide each polygon into four segments. Surface patches are generated by mapping each segment onto the corresponding segment of subsequent sections. A face table is constructed representing the surface patches and plane normals are generated for each patch. The normal and depth values are appended to the face table, and these measures determine the color intensity for each patch. Finally, patches are plotted providing a polygon mesh model, and each patch is filled with a dither pattern according to shading values. Three-dimensional reconstructions of the craniofacial region in Carnegie embryos (stages 15-17) are generated, and major morphological features are observed. Although bilevel shading capabilities cause discontinuous shading textures, this simple and inexpensive system can be easily upgraded for high-resolution graphics.

Computer Simulation↗
PubMedDate not supplied

"Medical Miranda"--improved emergency medical dispatch information from police officers.

INTRODUCTION: Medical Miranda, also called Secondary Emergency Notification of Dispatch (SEND), is a low cost, effective, and welcome addition to emergency medical dispatching systems. The benefits are recognized by emergency medical dispatchers who receive feeder calls from associated public safety agencies that have trained both their field staff and call-takers in the Medical Miranda protocol. HYPOTHESIS: The dispatchers would be more satisfied with feeder agencies that used the SEND protocol. METHODS: A survey was conducted and analyzed, taking advantage of a situation in which two agencies (one used SEND) fed calls to the same communication center. RESULTS: Dispatchers were more satisfied with the information gained from the feeder agency that used the SEND protocol and believed that the officers and dispatchers of that agency had a far better understanding of the emergency medical dispatcher's needs. CONCLUSIONS: When the emergency medical dispatcher does not talk directly with the reporting scene personnel or caller, Medical Miranda increases the usefulness of the information the dispatcher receives, helps the dispatcher better understand the reported medical emergency, and improves response appropriateness in emergency medical service (EMS) systems where responses routinely are prioritized.

Attitude of Health Personnel↗