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Biomedical subjects

B Sethia

Publications and source records attributed to B Sethia.

At least 55 records · Page 3Linked to original sources

Delay in diagnosis of right atrial myxoma.

Clinical, echocardiographic, and nuclear angiographic findings in a 51-year-old woman who presented with a history of dyspnea are discussed. Initial echocardiography revealed no abnormality. However, a subsequent radionuclide angiogram revealed a filling defect on the right side of the heart. This represented a right atrial myxoma. Radionuclide angiography can provide a useful noninvasive tool in the diagnosis of intracardiac tumors when echocardiography has not been helpful.

Diagnosis, Differential↗

Peak urine flow as a predictor of urine infection and retention after coronary artery bypass grafting.

Peak urine flow rates were measured in 83 men before coronary artery bypass grafting. The patients were grouped according to the method of Drach et al. [1] into those with normal, equivocal or abnormal flow rates. No cases of urine infection occurred in any of the 3 groups and only 2 patients in the group with abnormal peak flow developed urine retention. This was not statistically significant. Peak urine flow did not appear to be useful in predicting urine retention after coronary artery bypass grafting.

Adult↗

The effects of left atrial and left ventricular cannulation on left ventricular function.

A study in anesthetised dogs was undertaken to investigate the immediate effects of cannulation of the heart for left heart bypass on left ventricular function. Twenty-six mongrel dogs were studied. In the first group of 13 dogs (Group A), left atrial cannulation was performed through the atrial appendage and in the second group of 13 dogs (Group B), the left ventricular apex was also cannulated. Systemic blood pressure, heart rate, left atrial pressure, left ventricular end diastolic pressure and dP/dT showed no difference in left ventricular function between Groups A and B. Global ejection fraction (EF) measured by injection of technetium99m-labelled human serum albumen with gated left ventricular imaging, showed no significant difference between the two groups but analysis of the regional contribution to global EF in Group B dogs demonstrated a significant reduction in left ventricular function at the site of ventricular cannulation (P less than 0.05). These findings, together with other reported disadvantages of left ventricular cannulation, suggest that the left atrium is the preferred site for cannulation when left heart bypass is required. Many reports attest to the value of mechanical circulatory support in patients with ventricular dysfunction who cannot be weaned from cardiopulmonary bypass (2, 4, 10, 11, 15). Initial support is commonly provided by an intra-aortic balloon pump but, in more severe cases, use of a left ventricular assist device may be warranted. More recently, such devices have also been employed in the management of patients with cardiogenic shock refractory to medical therapy (10).(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

Empyema following intra-abdominal sepsis.

Over the past 9 years, ten patients have presented to the Thoracic Unit, Glasgow Royal Infirmary, with 12 empyemas secondary to intra-abdominal sepsis. In eight patients, the presenting signs and symptoms were wrongly attributed to primary intra-thoracic pathology. All were subsequently found to have intra-abdominal sepsis. The presence of empyema after recent abdominal surgery or abdominal pain strongly suggests a diagnosis of ipsilateral subphrenic abscess. Adequate surgical drainage is essential. In our experience, limited thoracotomy with subdiaphragmatic extension offers the best access to both pleural and subphrenic spaces and provides the greatest chance of eradicating infection on both sides of the diaphragm.

Abdomen↗

The surgical management of extravalvular aortic root infection.

Fifteen patients with extravalvular aortic root infection and associated infective endocarditis underwent urgent operation for this condition at Glasgow Royal Infirmary between 1977 and 1983. Four patients (26.7%) subsequently died between 1 and 68 months after operation. All patients underwent aortic valve replacement, with debridement or suture closure of abscess cavities as indicated. Three patients also required insertion of permanent pacing systems for complete heart block. Three other patients required further surgical intervention. Aortic valve rereplacement was done on two occasions in 1 patient and repair of a periprosthetic leak in the second patient; the third required one additional procedure to close an aorto-right atrial fistula postoperatively. Ten out of 11 survivors are in New York Heart Association Class I, and the remaining patient is in Class II. Aggressive surgical therapy without the need for complicated reconstructive procedures of the aortic root is effective in the management of extravalvular aortic root infections.

Abscess↗

Coronary artery bypass surgery--impact upon a patient's wife--a pilot study.

A pilot study of the wives of 19 coronary artery surgery patients assessed levels and predictors of affective symptoms. A substantial proportion of wives (40 to 50%) reported levels of depression (but not anxiety) severe enough to warrant treatment, and many attributed this to the effects of their husband's operation. Neither the wives' expectations of patient outcome, nor the objectively assessed surgical outcome bore any relationship to the wives' affective state. A previous psychiatric history in a wife was possibly related to her affective state, but her 'N' score (emotionality) on the Eysenck Personality Questionnaire was very strongly related to her state.

Affective Symptoms↗

Urethral stricture following cardiac surgery: a prospective study.

A prospective study was undertaken to assess the incidence of urethral stricture in 105 men undergoing coronary artery by-pass grafting. A pre-operative urological history was taken and peak urine flow rates measured before surgery, and 1 week and between 6 and 8 weeks after operation. All patients were catheterised in theatre with a standard type and size of urethral catheter and details recorded of the by-pass time and the degree of hypothermia. Postoperative urological problems such as urethral discharge and haematuria were noted. In addition, 100 patients completed a postal questionnaire about urinary symptoms between 4 and 12 months after surgery. The overall incidence of urethral stricture was 2%.

Adult↗

Abdominal aortic aneurysm with retroperitoneal fibrosis and ureteric entrapment.

Eleven of 157 patients undergoing surgery for abdominal aortic aneurysm, with features of both aneurysm and periaortic retroperitoneal fibrosis, are presented. The clinical details, implications and management are reported. The possibility that this association may present with differing relative severity of these two conditions is discussed. aortic replacement is advocated as the treatment of choice because the risk of rupture still exists and this procedure seems to halt, or even reverse, the inflammatory process. Synchronous ureterolysis is reasonably safe and can be undertaken if obstruction is present. Steroids represent an alternative option, where aortic replacement is too hazardous.

Aged↗