[Mucocele appendicis retrocaecalis].
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Aged↗
Biomedical subjects
B Serafin
Publications and source records attributed to B Serafin.
[Experimental evaluation of indirect defibrillation of the heart].
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Animals↗
[Effect of the clamping of external iliac vessels on the renal function].
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Animals↗
Antimalarial compounds. XIII. New derivatives of phenyl chloromethyl sulfone.
A series of chloromethylsulfonyl derivatives of amines, biguanides and amidineureas (Scheme 1) has been prepared and their antimalarial properties investigated.
Administration, Oral↗
Antimalarial compounds. XIV. New derivatives of 2-bromo-N,N-bis-(diethylaminoethyl)-4,5-dimethoxyanaline (RC 12).
The molecule of RC 12 which was found previously to exhibit antimalarial activity has been modified, by replacing groups in positions 1 and 2 by NHAr, S-Ar, NO2, sulfonamido and other substituents. The new derivatives (Table 1) were tested for toxicity and antimalarial activity agains Plasmodium berghei in mice (Table 2).
Administration, Oral↗
New amidine derivatives of indole.
A series of new derivatives of indole of expected biological activity was prepared. Amidines 7 and 8 were obtained from the corresponding nitriles 3 and 4 and iminoethers 6.
Amidines↗
Potential antihypertensive benzimidazole derivatives.
A series of benzimidazole derivatives was synthesized and tested for their hypotensive activity. The most interesting compounds were: BS1/81 (2-guanidino-benzimidazole) and BS1/84 (2-guanidino-5-aminobenzimidazole dihydrochloride), which effects were comparable to those of aminophylline. It was found that substitution of guanidine nitrogen atom with phenyl group caused a distinct decrease of activity while cyclization of guanidine rest to pyrimidine ring caused only a small decrease of activity.
Animals↗
Arylbiguanides and dihydro-s-triazines as potential hypotensive agents.
Series of dihydrotriazines and arylbiguanides were synthetized and tested for their hypotensive effect. Compounds I and II in doses corresponding to 0.2 of their LD50 produced small hypotension. The biguanides exerted the hypotensive effect when given in a dose of 0.05 of their LD50, but the effect was weaker than that of aminophylline.
Animals↗