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Biomedical subjects

B Serafin

Publications and source records attributed to B Serafin.

At least 19 recordsLinked to original sources
PubMed1991

[Data from the Wrocław region about thyroid diseases and use of prophylactic iodine after the reactor accident in Czernobyl].

The radiological contamination of Wrocław Region after Czernobyl accident was evaluated as moderate. In the frame of Research Programme MZ-XVII 4310 persons (2012 men and 2298 women) were randomly selected and investigated. Among them were 1525 children up to 16 years old. 925 children and 854 adults took potassium iodide; only minority in April but majority between May 1st and May 5th. Side effects was rare phenomenon seen in about 5% of those who ingested potassium iodide and in majority of cases was very mild (with rash and vomiting as most common clinical symptoms). Only 13 persons with side effects have visited physicians. Among 955 women aged 19-40 years 71 were pregnant in May 1986. 55 of them delivered on time, 3 before time. Average health state of newborns was 9.1 according to Apgar scale. 10 women have had spontaneous abortion and 3 decided to terminate pregnancy in first 6 weeks. The physical examination revealed the presence of diffuse goiter in 384 persons and of nodular goiter in 23 persons. In majority of cases the goiter was small, OB or I. according to WHO classification.

Adolescent↗
PubMed1986

Potential acetylcholinesterase reactivators: pyridine and alpha-oxooxime derivatives.

The synthesis and pharmacological screening in vitro and in vivo of pyridine-2-carbaldoxime derivatives I and alpha-oxooximes II are described. Four compounds elicited reactivating effect on phosphorylated acetylcholinesterase comparable with that of pralidoxime used as reference substance. Among the compounds tested, interesting structures are those of oximes bearing a thioether substituent [RA 49 (Table 1) and RA 59 (Table 2)] chloro derivative of MINA [RA 55 (Table 2)] and dipyridyl glyoxime methiodide RA 56 (Table 1).

Acetylcholinesterase↗
PubMed1984

[Experimental evaluation of two-sided velour vascular prostheses of Polish production].

The experiments were performed on nine mongrel dogs. The authors used straight crenated grafts of diameters 6 and 12 mm. In 6 dogs were implanted into abdominal aorta below an origin of renal arteries and above its bifurcation. Autopsy was performed after 49, 62, 98 days. The authors evaluated the implant examining it with two methods: macroscopic and histopathologic. In addition were 6 experiments made with three dogs. The grafts were placed extracorporealy between canulated artery and femoral vein. The authors measured the volume of transudated blood, the time of transudation and degree of grafts flexibility marked by the alongation. In was stated that tested double veloured grafts of Polish production are softer and more flexible than those produced so far. The edges of the tested grafts have higher shred resistance during the sewing procedure. Their more regular texture results in smaller degree of transudation: after initial typical preclotting the grafts "sweat" evenly and quickly stops the transudation. In authors opinion the grafts should be clinically evaluated in treatment of peripheral blood vessels diseases.

Animals↗
PubMed1980

[Lung contusion].

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Contusions↗
PubMed1976

Potential acetylcholinesterase reactivators: oxime and amidoxime derivatives.

Out of 12 oximes and amidoximes (3 of which were new to the literature) the following showed a distinct antilethal effect in DFP poisoning: RA14 (1-methylbenzimidazole-2-aldoxime methiodide), RA14 (pyridine-4-aldoxime dodecyl bromide), and RA24 (pyridine-2-aldoxime dodecyl bromide). These compounds also reactivated acetylcholinesterase (AChE) in vitro, but had no effect on this enzyme in vivo. Moreover, addition of the dodecyl chain to pyridinealdoxtimes, or in a less degree replacement of the pyridine ring with benzimidazole in aldoximes, distinctly increased acute toxicity and lipophilicity when compared with the parent pyridine compounds, along with protective action in DFP poisoning.

Acetylcholinesterase↗