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Biomedical subjects

B Sener

Publications and source records attributed to B Sener.

89 records · Page 5Linked to original sources
PubMedDate not supplied

Effect of some anti-inflammatory drugs on human neutrophil chemotaxis.

The effects of piroxicam, tenoxicam, diclofenac sodium, acetylsalicylic acid and tiaprofenic acid on the chemotaxis and random migration of human polymorphonuclear leukocytes were investigated, using zymosan-activated serum as chemo-attractant, with a modified Boyden chamber technique. All five compounds significantly reduced chemotaxis. The random migration of polymorphonuclear leukocytes was inhibited by piroxicam, diclofenac sodium and tiaprofenic acid but not by tenoxicam or acetylsalicylic acid. The inhibitory effect of these non-steroidal anti-inflammatory drugs on polymorphonuclear leukocyte chemotaxis and on random migration was generally dose-dependent. The results suggest that the drugs studied may have a direct effect on polymorphonuclear leukocyte chemotaxis and that this activity may contribute to their anti-inflammatory properties.

Adult↗
PubMedDate not supplied

Photorefractive keratectomy for hyperopia and aphakia with a scanning spot excimer laser.

OBJECTIVE: To study the safety, efficacy, predictability, and stability of photorefractive keratectomy (PRK) for hyperopia and aphakia. METHODS: Fifteen eyes of 15 patients (mean age, 33 +/- 5.95 yrs) were enrolled in the study and divided into three groups. The first group was comprised of six eyes that had hyperopia ranging from +1.75 to +4.75 D; the second group had seven hyperopic eyes ranging from +5.00 to +9.75 D; the third group included two eyes of two aphakic patients. All eyes had PRK with a 193 nm argon fluoride excimer laser (Chiron-Technolas, Keracor 116) with a 10 Hz repetition rate and a fluence of 120 mJ/cm2. The total follow-up time in all eyes was 12 months. RESULTS: In the lower hyperopia group, 0% eyes were within +/- 0.50 D and 66% (N = 4) of eyes were within +/- 1.00 D of emmetropia with the other two eyes between +1.00 and +2.00 D at 1 year after PRK. In the higher hyperopia group, all eyes had at least +3.00 D of hyperopia at 1 year. In the aphakic group, both eyes achieved less than 50% of the target correction of +10.00 D at 1 year. Final uncorrected visual acuity ranged from 20/20 to 20/30 in the lower hyperopia group, 20/30 to 20/50 in the higher hyperopia group, and count fingers in the aphakic group. CONCLUSIONS: PRK is a relatively safe, stable, and effective procedure with reasonably good predictability for eyes with less than +5.00 D of baseline hyperopia, and poor predictability for eyes with more than +5.00 D of baseline hyperopia. PRK is ineffective in the correction of aphakia.

Adult↗
PubMedDate not supplied

Decreased tear secretion after laser in situ keratomileusis for high myopia.

PURPOSE: To investigate the changes in tear secretion and tear film stability after excimer laser in situ keratomileusis (LASIK) for high myopia. METHODS: One eye of 28 patients underwent unilateral LASIK for the correction of myopia with spherical equivalent refractions ranging from -6.37 to -18.25 D (mean, -11.98 +/- 3.45 D). Schirmer tear test values without anesthesia at 5 minutes and tear break-up time values were measured 4 weeks after LASIK. Unoperated contralateral eyes were used as a control for each patient. The Schirmer tear test and tear break-up time values were analyzed statistically using the independent t-test. RESULTS: The mean Schirmer tear test value was 16.17 +/- 2.50 mm in the operated eyes and 21.07 +/- 7.03 mm in the unoperated (control) eyes of the same patients (P = .001). The mean tear break-up time value was 21.0 +/- 3.55 seconds in the operated eyes and 21.27 +/- 6.79 seconds in the control eyes (P = .85). CONCLUSION: Tear secretion decreased following LASIK probably due to decrease in corneal sensitivity, but tear film stability appeared unaltered.

Adult↗
PubMedDate not supplied

Retinal detachment following laser in situ keratomileusis.

OBJECTIVE: To report the clinical characteristics, surgical management and outcome of retinal detachment following laser in situ keratomileusis (LASIK) in myopic patients. PATIENTS AND METHODS: Retrospective review of 10 eyes of 10 myopic patients with retinal detachment who had previously undergone LASIK surgery were analyzed. Included in the study were 7 males and 3 females, aged 22 to 68 years (35.2+/-2.8). RESULTS: Mean spherical equivalent refraction was -10.51+/-3.90 D (ranging from -6.37 D to -17.00 D) before surgery. The time interval between the LASIK procedure and the development of retinal detachment varied from two months to nine months (5.2 +/- 2.78 months). The number of retinal breaks was one in 7 patients, two in 2 patients and three in 1 patient. The type of retinal breaks included 7 patients with horse shoe tears, 1 patient with a retinal hole, 1 patient with a giant retinal tear, and 1 patient with retinal dialysis. Retinal breaks were located anterior to the equator in 9 patients and posterior to the equator in 1 patient. Retinal reattachment was achieved with one operation in 8 eyes (80%) and the remaining 2 eyes required a second surgery for the reattachment of the retina. CONCLUSION: This study suggests the possible association between retinal detachment and LASIK procedure in patients with myopia. Clinicians should be aware of retinal pathology predisposing to retinal detachment in patients undergoing LASIK.

Adult↗
PubMedDate not supplied

Fluoride retention by human enamel after in vitro application of nicomethanol hydrofluoride.

Fluoridated dentifrices generally contain sodium monofluorophosphate or sodium fluoride--alone or in combination--or a group of organic fluorides, the amine fluorides. The purpose of this study was to determine the fluoride and retention in vitro by human enamel, after brushing with a dentifrice containing the amine fluoride, nicomethanol hydrofluoride, the fluoride salt of nicotinyl alcohol.

Administration, Topical↗
PubMedDate not supplied

In vitro dissolution of human enamel after application of a mixture of stannous fluoride and amine fluoride 297: a pilot study.

Human enamel specimens were topically treated in vitro, using either a clear, aged aqueous mixture consisting of SnF2 and amine fluoride 297, or SnF2 alone, amine fluoride 297 alone, NaF, or water (as the negative control). The fluoride concentrations used were 250 ppm F1/n. The topically treated enamel specimens were then acid-etched for 5, 10, 15, and 15 seconds, respectively, in 2NHC1. The amount of phosphorous dissolved from the enamel and the depth of etch were both significantly less for the groups treated with SnF2/AmF297 and SnF2 alone, which indicated better protection against acid dissolution than the other three groups.

Acid Etching, Dental↗
PubMedDate not supplied

Sputum bacteriology and its antibiotic susceptibilities in Turkish cystic fibrosis patients.

To identify lower respiratory tract pathogens and their in-vitro antibiotic susceptibilities in Turkish cystic fibrosis (CF) patients, a total of 383 sputum cultures were evaluated from 45 CF children in 168 symptomatic and 215 control periods over 25 months. Microorganisms were isolated in 252 of the cultures. The isolation rate was 82 percent for symptomatic periods and 53 percent for control periods. The most common microorganism was P. aeruginosa in the symptomatic period and S. aureus in the control period. Other microbiological species included E. coli, H. influenzae, K. pneumoniae, S. epidermidis, beta-hemolytic streptococcus, H. parainfluenzae, K. oxytoca, E. aerogenes and E. aglomerans. P. cepacia was not found. In 20 cultures more than one microorganism was isolated at the same time. In in-vitro conditions, high susceptibility rates were detected to amikacin, ciprofloxacin and ceftazidim for P. aeruginosa; cefuroxime, ceftriaxone, amikacin, cephalothin, chloramphenicol and erythromycin for S. aureus; amikacin and ceftriaxone for E. coli; ampicillin-sulbactam, amoxicillin-clavulanate, cefuroxime, ceftazidime, ceftriaxone and aztreonam for H. influeanzae; and aztreonam and amikacin for K. pneumoniae. Lower respiratory tract pathogens and their antibiotic susceptibilities in Turkish CF children were not significantly different from those indicated previously in the literature.

Adolescent↗