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Biomedical subjects

B Seifert

Publications and source records attributed to B Seifert.

At least 181 records · Page 10Linked to original sources
PubMed1982

[Comparison of concentrations of inorganic and organic compounds occurring inside and outside closed rooms].

Although many people spend more than two thirds of their day indoors, most epidemiological studies on the health effects of air pollutants have up to now only been based on ambient air quality measurements. Using data from the literature, information is collected on the indoor-outdoor relationship of pollutant concentrations in order to estimate in which cases data on ambient air quality have to be completed by the results of indoor air measurements during epidemiological studies. For air pollutants like sulphur dioxide, nitrogen dioxide, carbon monoxide, suspended particulate matter, polycyclic aromatic hydrocarbons and nitrosamines the long-term average concentrations found indoors exceed those found outdoors only when tobacco smoke or other visible sources, e.g. gas appliances, are present in the room. A table is given which shows average indoor-outdoor ratios for the different cases. A number of organic substances, however, can be expected to be encountered in much higher concentrations indoors than outdoors. One of the main reasons for this is the use of a great variety of organic substances in modern building materials and household products. During the application of one or more of the multiple consumer products offered nowadays it is not unusual that the indoor air for several hours may show concentrations of organic substances which exceed those found in ambient air by a factor of more than 50.

Air Pollutants↗
PubMed1978

[Corpus luteum function in the middle luteal phase following treatment with prostaglandins].

The corpus luteum of the mid-luteal phase was examined concerning of the signs of functional and morphological regression after treatment with Prostin F2alpha and 15(S)-15-methyl-PGF2alpha. By 8 patients who were operated upon out of various uterine indications steroid hormone levels were determined during the treatment with prostaglandins and corpus luteum was judged by electron-microscopy. Morphological changes in the temporary decrease of the progesteron concentration could be found.

Corpus Luteum↗
PubMed1978

[Abortion induction in early pregnancy using prostin F2 alpha and 15(S)-15-methyl PGF 2 alpha].

In early pregnancy up the 8th week of pregnancy Prostin F2 alpha was infused and 15(S)-15-Methyl PGF 2 alpha was used i.m. to induce menstruation in 20 or 19 cases, respectively. In the tested form application 15(S)-15-Methyl PFG 2 alpha is effective in 89 per cent of the cases and in 74 per cent complete abortion was achieved, Prostin F 2 alpha produced bleeding in 80 per cent only and complete abortion in 55 per cent. The differences in these two groups were not statistically significant.

Abortifacient Agents↗
PubMed1978

[Uterine prostaglandins and dysmenorrhea].

In 44 patients a total of 83 determinations in the menstrual blood was performed under standardized conditions. -- The primary PGE 1 and PGF 2 alpha were determined by RIA. Significant differences were found in the PGF 2 alpha concentration in menstrual blood between a group of healthy women and one of patients with dysmenorrhoea. -- In dysmenorrhoea the ration of the PGs investigated is shifted in favour of PGF 2 alpha. Indomethacin can decrease the PGF 2 alpha levels in dysmenorrhoea up to 15 per cent. -- All treated patients reported that their conditions had improved. -- Five out of seven women were completely without any complaints.

Dysmenorrhea↗
PubMed1978

[Formation of primary prostaglandins E1 and F2 alpha in the uterus and ovary. Studies on plasma concentrations in local blood vessels].

The blood vessels of uterus and ovary were prepared of 20 patients during abdominal hysteroophorectomy and blood samples were taken for determination of prostaglandins. -- Blood samples from vena cubitalis were taken as comparison example. -- The determination of prostaglandins was carried out radioimmunologically. -- The content of prostaglandins in the plasma of uterine vein for PGE 1 and PGF 2 alpha with 315 and 324 pg/ml is higher than the comparison concentration in the uterine artery and cubital vein. Venous concentration in the ovary for PGE 1 with 408 pg/ml and PGF 2 alpha with 677 pg/ml are increased in opposition to the control value.

Female↗
PubMed1978

Prostaglandins and primary dysmenorrhoea.

In 100 patients a total of 171 PG determinations in the menstrual blood was performed under standardized conditions. The primary PGE1 and PGF2alpha were determined by RIA. The evaluation of the analysis of the sexual hormones resulted in a group with a biphasic cycle without dysmenorrhoea and a group with a biphasic cycle with dysmenorrhoea. Highly significant differences (p less than 0.01) were found in the PGF2alpha concentration in menstrual blood between a group of healthy women and one of patients with dysmenorrhoea. In dysmenorrhoea the ratio of the PGs investigated is shifted in favour of PGF2alpha. Indomethacin can decrease the PGF2alpha levels in dysmenorrhoea up to 15% (p less than 0.01). All treated patients reported that their conditions had improved. Five out of seven women were completely without any complaints.

Dysmenorrhea↗
PubMed1978

Investigations of hormones during early abortion induced by prostaglandin F2alpha and 15(S)-methyl-PGF2alpha.

In early pregnancy up the 7th week of pregnancy PGF2alpha was infused and 15(S)-methyl-PGF2alpha was applied i. m. to induce menstruation in 20 or 19 cases, respectively. In the tested form of application 15(S)-methyl-PGF2alpha is effective in 89 per cent of the cases and in 74 per cent complete abortion was achieved. PGF2alpha produced bleeding in 80 per cent only and complete abortion in 55 per cent. The differences in these two groups were not statistically significant. The steroid hormones estradiol and progesterone decrease in a successful application of PGs for induction of abortion and reach a value of 75 per cent at the onset of bleeding. The LH concentration in plasma becomes smaller too. In some cases there is a temporary increase in hormones shortly after starting treatment. The results could indicate that the considerable decrease in hormones before the onset of bleeding might be caused by an alteration of the corpus luteum, which is effective during early pregnancy.

Abortion, Induced↗
PubMed1977

[Determination of heat stable alkaline phosphatase].

In this work the method for determination of serum heat-stable alkaline phosphatase (HSAP)--valuable as a placenta function test in pregnancy--is discussed. There are different informations about the optimal conditions for inactivating the nonplacental heat labile isoenzyms, and therefore the opinions on the clinical efficiency of HSAP vary in different studies. Sera of nonpregnant and pregnant females were heated at 40 degrees to 65 degrees C for 5 to 60 minutes. It is demonstrated, that in opposite to suggested opinions in several reports a temperature of 56 degrees C for 30 minutes is notsufficient to inactivate all nonplacental alkaline phosphatase isoenzymes. At 60 degrees C for 20 minutes and at 65 degrees C for 5 minutes in sera of pregnant and nonpregnant female controls we could find concordant results, so that these two conditions of inactivation are regarded as the best. We prefer a temperature of 60 degrees C and inactivate for 20 minutes, since these conditions are to reproduce more easy and allow a beter precision of the results, than 65 degrees C for 5 minutes.

Alkaline Phosphatase↗
PubMed1977

[Intravenous induction of labor with prostaglandins F2alpha].

Report on 60 patients with induction of labour by intravenous infusion of prostaglandin F2alpha. The high rate of success (95%) was attributed to some favourable factors. Side effects were minimal. Moreover no effects on the metabolism were observed. During labour a electronical and biochemical supervision is neccessary.

Blood Glucose↗