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Biomedical subjects

B Schmidt

Publications and source records attributed to B Schmidt.

At least 559 records · Page 31Linked to original sources

A 3'-deoxymononucleotide-producing nuclease from the marine sponge Verongia aerophoba. II. General properties.

The properties of a 3'-deoxymono-nucleotide-producing nuclease highly purified from the marine sponge Verongia aerophoba are described. The hydrolysis of heat-dentured DNA-proceeds at about five fold the rate of native, double-stranded DNA. The enzyme behaves as an exonuclease by producing 3'-deoxymononucleotides. Kinetic analysis by means of initial hyperchromicity at 260 nm indicates that the enzyme requries 120 mmol/l of mono-valent and 30 mmol/l of divalent cations with a clear dependence on ionic radius. The enzyme has a pH optimum at 4.7, the pH value of the isoelectric point is 6.1. The molecular weight has been evaluated at 62,000.

Animals↗

[Hazards of heart catheterization and angiocardiography in the first year of life. A review of 1366 examinations].

1366 infants in the first year of life had cardiac catheterisation with or without angiocardiography in our Department of Cardiology between 1963 and 1973. The overally mortality in the first 24 hrs after the cardiac catheterisation for the first year of life was 1.83%. The subdivision of the first month of life reveals the high mortality rate of the first two weeks of life with the highest percentage of 18.9% in the first week of life and with 10.7% in the second week of life. After that time the mortality is significantly decreasing, but still amounts to 7.6% in the first month of life. There had been no death after the seventh month of life. 14 of the 24 infants died without a specific event in increasing heartfailure and/or acidosis. In the other 10 cases death was due either to the manipulation of the catheter (partial-perforation or perforation), to the angiocardiogram (subsequent asystole) or to the position of the catheter with subsequent intramural injection of contrast material.The best correlation was between the mortality and the severity of the underlying cardiac malformation. Further complications which did lead to death 24 hrs following cardiac catheterisation are described. Our results are compared with those of other authors. The reasons of various complications are discussed. Cardiac catheterisation and angiocardiography as early as possible is necessary because palliative procedures and corrective surgery can be initiated immediately. But it is important in the very sick infant to shorten the procedure as much as possible and to keep angiographic injections at a minimum.

Acidosis, Respiratory↗

[Vectorcardiographic study on the right hypertrophy diagnosis in complete right bundle branch block].

Vectorocardiograms were led and interpreted by means of quantitative and qualititive criteria in 100 children with a complete block of the right bundle-branch occurring after correcting surgery of tetralogy of Fallot or isolated defect or the ventricular septum. The results are discussed after demonstrating the pathophysiological patterns of excitation associated with right ventricular hypertrophy and complete block of the right bundle-branch. After a survey of the literature a precise summary of the results is given in order to distinguish clearly by differential diagnosis necessary for postoperative observation of the vitiae cordis mentioned above, between complete block of the right bundle-branch and right ventricular hypertrophy. 4 vetorcardiograms were selected out of the total number of loops for demonstration of the defined criteria for right ventricular hypertrophy associated with complete block of the right bundle-branch.

Adolescent↗

[Single atrium].

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Angiocardiography↗