Biomedical subjects
Publications and source records attributed to B Rothschild.
Some of the collagen-vascular diseases and overlap syndromes included are polymyosititis, systemic lupus erythematosus, scleroderma, Sjögren's syndrome, and Raynaud's phenomenon. Because diagnosis and treatment can be complicated, primary care physicians may want to seek experienced consultation.
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The purpose of this article is to present an assessment method, in conjunction with age-related normal values, for lumbar spinal range of motion. Lumbar flexion, lumbar extension, and right and left lateral flexion were measured on 172 subjects by a combination of goniometry and spinal distraction techniques. Normal values are given for six age groups; each group had a range of 10 years. The results demonstrate that a significant decrease in lumbar spinal range of motion is expected with increasing age. The interobserver reliability based on 17 subjects was substantial for the four measurements taken; coefficients ranged from +.76 to +1.0. The information may prove useful to the clinician as an improved method for assessing the lumbar spine.
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Equations describing plaque formation in soft agar have been based on certain simplifying assumptions, for which data are presented. The derived equations permit one to calculate (i) average plaque size as a function of the initial density of indicator cells (Do), (ii) the number of cells lysed per plaque as a function of Do, and (iii) the cumulative number of cells lysed at various stages of plaque development. The calculated values agree well with those determined experimentally.
Excretory urography is not an infallible diagnostic procedure and should not be relied upon exclusively. A normal study must never result in the rejection of additional data derived from history, physical examination and laboratory tests. Two case histories are presented to underscore this caveat. Excretory urography must be supplemented additional radiographic evaluations when the conventional study fails to completely explain the clinical situation.
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The possible osseous effect of kidney dysfunction was evaluated in a modern skeletal population for future use in assessment of archaeologic samples. Frequency and distribution on the bones of cysts, articular surface alterations, subperiosteal resorption, porosity, osteochondritis, digital tuft alteration and periosteal reaction were recorded in 94 individuals with known kidney failure in the Hamann-Todd collection. Independent radiologic analysis was also pursued. The results were compared with a control sample. The pattern of joint surface alteration and periosteal reaction may facilitate recognition of chronic renal disease in the osseous record. Subtle manifestations of leontiasis ossium are present in the form of cranial thickening and increased cranial size and weight, but teeth spacing are rare. Pseudo osteomatous lesions are common. This study perhaps explains the apparent rarity of actual leontiasis ossium.
As paleopathology has evolved from observational speculation to analysis of testable hypotheses, so too has recognition of its contribution to vertebrate paleontology. In the presence of significant structural and density variation (between matrix and osseous structures), x-rays provide an additional perspective of osseous response to stress and disease. As film techniques are time and cost expensive, fluoroscopy has proven a valuable alternative. Radiologic techniques also allow non-invasive "sectioning" of specimens, illustrating significant internal detail. The object can be "split" on a plane and the two portions rotated to "open" the image. This three-dimensional approach now can be applied to other forms of sequential data to their facilitate 3-dimensional representation graphically or with solid representations. Antigen and microstructure may be well preserved in fossils. Molecular preservation with retention of helical structure and sensitivity to collagenase has been demonstrated in 10,000 year old collagen. Antigen has been extracted from 100 million year old bone and documented, in situ, in 11,000 year old bone. If the appropriate site in the tissue is assessed, if antigen is still present, and if the appropriate antisera is utilized, fixation of the antibody to the specimen can be detected. Minute amounts of DNA can be amplified and analyzed. Recovery of DNA from a 40,000 year old mammoth, 17,000 year old bison and from 25 million year old insects provides opportunity for cloning and independent assessment of relationships. Implications of available technology focuses direction for development of collaborative approaches.
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