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Biomedical subjects

B Rosner

Publications and source records attributed to B Rosner.

At least 379 records · Page 21Linked to original sources
PubMed1975

Isolation of genital mycoplasmas from blood obtained shortly after vaginal delivery.

Blood obtained from three hundred and twenty-seven women within a few minutes of vaginal delivery was cultured for genital mycoplasmas (Mycoplasma hominis and T mycoplasmas). Twenty-six (8%) of the women had genital mycoplasmas isolated from their blood. Ten women had blood-cultures which contained M. hominis. Fifteen women had blood-cultures which contained T mycoplasmas. Both M. hominis and T mycoplasmas were isolated from the blood of one woman. Only one of two hundred and seventy-three blood-cultures obtained 1 or more days after delivery contained mycoplasmas. The isolation of M. hominis, but not of T mycoplasmas, from the blood was associated with vaginal colonisation and a serological response to the homologous isolate. Two of ten women whose blood contained M. hominis gave birth to stillborn infants. In contrast, there were only four (1.3%) stillbirths among the infants born to the three hundred and one women whose blood did not contain mycoplasmas. This difference is statistically significant.

Adolescent↗
PubMed1975

Relation between regular intake of phenacetin-containing analgesics and laboratory evidence for urorenal disorders in a working female population of Switzerland.

A study group of 623 employed Swiss women aged 30-49 years showing objective evidence of intake of phenacetin-containing analgesics, and a control group of 621 comparable women showing no such intake, were observed for 4 years (1969-72) for laboratory evidence of urorenal disorders. In both study and control groups morbidity was low. There was no difference between the study and control groups with respect to subsequent proteinuria, bacteriuria, and haematuria. The 4-year incidence of low urine specific gravity after overhight thirsting was significantly higher in the study group than in the control group (3-8% v. 0-8%) and the incidence of raised serum-creatinine was also significantly higher in the study group (2-9% v. 0-4%). However, when the study group was further subdivided into a sub-group showing evidence of high intake of phenacetincontaining analgesics and one showing low intake, only the high-intake subgroup had an incidence of raised serum-creatinine (5-4%) significantly higher than the control group (0-4%), whereas the low-intake subgroup had an incidence (0-4%) similar to the control group.

Acetaminophen↗
PubMed1975

Disk diffusion and serial dilution tests of susceptibility of some pathogenic gram-negative bacilli and enterococci to carbenicillin and ampicillin.

Tests for susceptibility to ampicillin and carbenicillin were performed with 35 strains each of Klebsiella, Enterobacter, Serratia, and Proteus, 71 strains of Pseudomonas aeruginosa, and 68 strains of enterococci by serial dilution and disk-diffusion tests employing 10(-3) dilutions of overnight cultures as inocula for both. Commercial 10-mug ampicillin and 50- and 100-mug carbenicillin disks, and freshly prepared 10-, 50-, and 75-mug ampicillin and 10- and 50-mug carbenicillin disks were used. Results were displayed as cumulative distribution curves for both minimal inhibitory concentrations and zone diameters, and as scattergrams for correlating them. Differences in susceptibility to the two antibiotics were small for Klebsiella, Enterobacter, and Serratia and large for the others. The freshly prepared and commercial disks of the same content gave comparable zones. There was good correlation of zone diameter with each disk and the minimal inhibitory concentration. Among the ampicillin disks tested, none was useful for Pseudomonas; with the other species, the 10-mug disk, as well as those with higher ampicillin content, could discriminate susceptible from resistant strains. However, only the 75-mug disk selected some Klebsiella strains susceptible to high concentrations. The 50- and 100-mug carbenicillin disks were equally discriminating for most strains, but the higher concentration was more selective for Klebsiella. The 10-mug carbenicillin disk was as effective as the 50- and 100-mug disks for discriminating among Enterobacter, Serratia, Pseudomonas, and Proteus, but not for Klebsiella or enterococci. The 10(-3) inoculum gave zone sizes considerably larger than those reported by other workers who used the standard Kirby-Bauer method.

Ampicillin↗
PubMed1975

Sequence effect on ampicillin blood levels noted in an amoxicillin, ampicillin, and epicillin triple crossover study.

Amoxicillin, ampicillin, and epicillin (500 mg of each) were given orally to fasting men and women in a triple crossover study. Peak serum concentrations were significantly higher for amoxicillin than for ampicillin and significantly lowest for epicillin. The concentrations of antibiotics in serum were comparable in men and women. Total urine recovery was highest for amoxicillin (56.7%) and lowest for epicillin (27.5%), and higher in men than in women for each of the three antibiotics. Saliva, sweat, and tears contained only very small amounts of amoxicillin and, rarely, ampicillin or epicillin. A significant (P < 0.02) sequence effect was noted in that peak serum concentrations of ampicillin were higher (6.4 mug/ml) if epicillin had been taken the previous week than when ampicillin was taken first (2.7 mug/ml).

Adult↗
PubMed1974

A longitudinal study of blood pressure in childhood.

Blood pressures were taken in 609 children aged 6-18 in 163 families, 549 of whom had been studied 4 years earlier. Age and sex adjusted scores were expressed in standard deviation units (SDU). Analysis of variance again revealed the variance of blood pressures within families to be significantly less than among all children in this age group (p is less than 001. There was a significant positive relation between the follow-up and initial readings (regression coefficients: 0.24,p is less than .001 for systolic and 0.14,p = .001 for diastolic pressures). Of 88 children with initial systolic scores greater than 1 SDU above the mean, 65 percent had positive scores at follow-up, and 57 of 81 (70 percent) children with initial systolic scores less than 1 SDU below the mean had negative scores at follow up. These data suggest that stratification of blood pressures within peer groups begins and is detectable in childhood.

Adolescent↗
PubMed1974

Comparison of spectinomycin hydrochloride and aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea.

Men and women with uncomplicated gonorrhea were randomly assigned to receive aqueous procaine penicillin G (2,400,000 U for men; 2,400,000 U daily for 2 days for women) or spectinomycin hydrochloride (2.0 g for men; 4.0 g for women). Among men who returned for post-treatment evaluation within 10 days, treatment failures were noted among 16 (20.3%) of 79 men who received penicillin and 8 (9.5%) of 84 men who received spectinomycin (P < 0.1). Similarly, 6 (13.3%) of 45 women who received penicillin and 3 (6.5%) of 46 women who received spectinomycin had positive endocervical cultures for Neisseria gonorrhoeae at the time of the post-treatment examination (P = not significant).

Female↗
PubMed1974

The genetics of the Alport syndrome.

Analysis of the age at death of males with the Alport syndrome points out two distinct populations: one in which males die between ages 16 and 28 years, and the other in which males die between ages 33.5 and 52.2 years. Evidence suggests that these result from different genes of large effect. The segregation ratios of children of parents with Alport syndrome of either variety are generally consistent with an autosomal dominant mode of transmission, but the anomalous segregation from affected fathers remains to be explained.

Adolescent↗
PubMedDate not supplied

The 2 x 2 factorial design: its application to a randomized trial of aspirin and carotene in U.S. physicians.

The 2 x 2 factorial design calls for randomizing each participant to treatment A or B to address one question and further assignment at random within each group to treatment C or D to examine a second issue, permitting the simultaneous test of two different hypotheses. This design can increase the efficiency of large-scale clinical trials. The Physicians' Health Study, a randomized trial of aspirin and beta-carotene among U.S. physicians, illustrates some features and potential problems in the design and analysis of a factorial trial. The most common concern, interaction between treatments, is generally an advantage rather than a limitation of this design. Although such interactions are relatively uncommon, this design provides a means to measure an effect which otherwise might not be apparent. If the interaction is sufficiently severe, however, then loss of power is possible.

Aspirin↗
PubMedDate not supplied

The use of an autoregressive model for the analysis of longitudinal data in epidemiologic studies.

Korn and Whittemore have presented methods for analyzing longitudinal data where the number of observations per individual is large relative to the number of variables considered for each subject. However, this is often not the case in epidemiologic studies, since one usually collects data at relatively few time points, and the quantity of data collected for each individual at each time point is typically extensive. We present here an autoregressive model for analyzing longitudinal data of this type for the case of a continuous outcome variable. Some of the important features of this model are that one can in the same analysis, consider both independent variables that are time-dependent and those that are fixed over time, partially use data for an individual where some examinations are missing, assess relationships between changes in outcome and exposure over short periods of time, use ordinary multiple regression methods. Anderson has considered this type of model, but, to our knowledge, the model has never been applied to biostatistical problems. We illustrate these methods with data from a longitudinal study that seeks to identify the role of personal cigarette smoking on changes in pulmonary function in children.

Adolescent↗