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Biomedical subjects
Publications and source records attributed to B Rogers.
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Seventeen-wk-old turkey tom breeder candidates were allowed access to water for 4 h each day, as 2 x 2-h periods, to 21 wk. After this time, water access was reduced to 1.5 h/day (21 to 25 wk) and subsequently to 1 h/day (25 to 33 wk). Access time was reduced over time, as the earlier water access time allocation was considered excessive. With 1-h access time each day (2 x 30 min) there were no behavioral signs of thirst, and toms did not use the total time allocation for drinking. Restricted access to water reduced body weight from 25 to 33 wk of age (P less than .05). This BW reduction was accompanied by a nonsignificant reduction in feed intake. At 35 wk of age, semen weight (P less than .05) and sperm count (P less than .01) was increased for toms previously subjected to restricted water-access time. It is concluded that restriction of time that toms are allowed to drink can be used to augment other methods used in control of body weight.
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We report on a girl with Menkes syndrome (M.S.) and X-2 reciprocal translocation. We conclude that the probable locus for M.S. gene is at band Xq13. This case and other previous case reports of X-linked disorders in females suggest that chromosome analysis is indicated in all females who present with manifestations of a known X-linked lethal condition in order to detect a possible associated balanced X-autosome translocation.
Adult male Fischer-344 rats were given bilateral injections of 2.5 micrograms colchicine or artificial cerebrospinal fluid into caudal and rostral sites of the dentate gyrus of the hippocampus. One group of rats received 21 consecutive daily injections of 20 mg/kg GM1 gangliosides, i.p., beginning the day prior to surgery. Another group received saline. Colchicine-induced hypermotility was not seen in animals repeatedly handled 21 d after surgery, in spite of significant decreases in granule cell number and decreases in the volume of hippocampal mossy fibers. Pretreatment with GM1 had no effect on behavior and it did not protect against the hippocampal damage produced by colchicine. Rats given colchicine, but not handled for 21 d, showed significant hypermotility, which was associated with decreases in hippocampal granule cells. These data underscore the importance of handling in postlesion functional recovery.
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