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Biomedical subjects

B Richards

Publications and source records attributed to B Richards.

At least 145 records · Page 8Linked to original sources
PubMed1980

Influence of pH on the response of cells to single and split doses of hyperthermia.

The time course of development and loss of thermotolerance in Chinese hamster ovary cells exposed to 42 degrees was determined. The influence of pH on the heat sensitivity of normal and thermotolerant cells was examined. Exposure of cells to single graded heat treatments at pH 7.4 resulted in a decrease in survival to 5 to 10% after 3 to 4 hr treatment. Continued heating for an additional 4 to 5 hr resulted in an additional decrease in survival by a factor of only 1 to 2. At pH 6.7, exposure of cells to single heat treatments caused a marked reduction in survival to congruent to 0.02% after 3 hr treatment, and resistance to further killing was not evident until survival decreased to congruent to 0.001%. Cells initially heated at pH 7.4 for 3 hr and then stored at 37 degrees remained resistant to additional treatment for up to 48 hr later. Thermotolerance began to decay 72 hr after the initial treatment and was lost when 144 hr separated the treatments. The marked resistance to second treatments was observed irrespective of the pH at the time of the second treatment. Parallel studies also established that the viable progeny of heated cells remained resistant to hyperthermia for more than one postheat generation. These studies suggest that low pH conditions occurring in tumors may be expected to maximally influence response when fractionation intervals are sufficiently long that thermotolerance decays between treatments.

Animals↗
PubMed1979

Complications of antifibrinolysis therapy after prostatectomy.

As part of a trial to compare the effectiveness of various agents which have been claimed to reduce blood loss after prostatectomy, tranexamic acid (AMCA) was given pre-operatively and post-operatively to 6 patients having routine transurethral resections. Three of these developed indissoluble intravesical blood clots which persisted until they were evacuated surgically 5 to 17 days after cessation of AMCA therapy. AMCA cannot be recommended for routine use after prostatectomy.

Cyclohexanecarboxylic Acids↗
PubMed1979

Acute phase reactant proteins in the clinical management of carcinoma of the bladder.

The levels of a number of acute phase reactant proteins have been measured in 250 patients with carcinoma of the bladder in all stages. Three of them, acid glycoprotein, antichymotrypsin, and C-reactive protein, frequently gave abnormal results in advanced disease. The levels of these 3 proteins in patients who were clinically tumour-free were not distinguishable from those from an age-matched control group. The levels in patients with T1 and T2 bladder tumours were sometimes elevated. In advanced disease, figures were commonly above the normal range.

Adult↗
PubMed1979

Faecal and introital bacteria and urinary tract infection.

The faecal, introital, and urinary bacterial flora have been studied in 3 normal women and 5 women with recurrent urinary infection. In the normal women urinary abnormalities were uncommon, but the patients regularly had episodes of bacteriuria and pyuria, only a quarter of which were symptomatic. Symptoms tended to be associated with high white cell excretion rates and with the longer episodes. Introital colonisation was heavier and more frequent in the patients than in the control subjects. Organisms recovered from the urine had previously colonised the introitus in most cases. It appears that symptomatic episodes constitute only a small part of the disease process in patients with recurrent urinary tract infection.

Adult↗
PubMed1979

The effect of oxytocin in induced labour on neonatal jaundice.

A prospective study in 180 mothers and babies examined the effects of oxytocin in induced labour on plasma bilirubin levels in cord blood, as well as on the incidence of neonatal jaundice. Raised plasma bilirubin levels in cord blood, probably enhanced by breakdown of fetal red cells, appeared to be a dose dependent effect of oxytocin. Commensurate with this was the finding that a larger proportion of babies in the induced group manifested a greater severity of jaundice.

Bilirubin↗
PubMed1978

How much physical therapy for patients with stroke?

The use of physiotherapy, occupational therapy, and speech therapy for patients with stroke was investigated, and the three treatments were compared. Out of 135 patients with stroke surviving at two weeks, 107 received physiotherapy, but only 35 received occupational therapy and 19 speech therapy. Those who received most physiotherapy were the most severely disabled and had the worst prognosis, and, although almost no recovery occurred after six months, 30 patients continued with treatment beyond this time. Stiff and painful shoulders were present in 21 of the patients by two weeks and had developed in a further 37 by one year. Physiotherapy did not prevent this. The objectives of physiotherapy for patients with stroke need careful definition, with emphasis on treatment in the early months. Alternative treatment, possibly carried out by volunteers or more simply trained personnel, merits further consideration.

Aged↗
PubMed1978

Neurological sequelae in newborn babies after perinatal asphyxia.

A total of 53 babies, 37 to 44 weeks' gestational age with a history of fetal distress in labour, and severe neurological abnormalities in the early newborn period, were followed up for between 2 and 5 years. Their progress was compared with an equal number of normal babies matched for gestational age, birthweight, sex, and social class, but without a history of fetal distress or delay in establishing spontaneous respiration at birth. In the set of babies with a history of fetal distress no perinatal condition was identified that could predict with certainty the type of neurological status in the newborn period, or the occurrence of neurological abnormality in later childhood. Follow-up disclosed a considerable improvement in function in most of the apparently brain-injured babies. It is suggested that such babies exhibiting apathy initially but subsequently hyperexcitability and extensor hypertonia carry the worst prognosis.

Asphyxia Neonatorum↗
PubMed1977

The sub-structure of nucleosomes.

A model for the sub-structure of the core particle of the nucleosome in chromatin, based on results from neutron and x-ray scattering and other physico-chemical observations, is presented. Two disc-shaped heterotypic tetramers of histones, opposed face-to-face, form the core protein. Each tetramer is enclasped by an annulus of DNA and the two annuli are joined by a linker piece. The mode of self assembly of core particles in solution is derived as are the changes in conformation of the core particle which occur on transcription and chromosome replication.

Animals↗
PubMed1977

Intravesical epodyl in the management of bladder tumors: combined experience of the Yorkshire Urological Cancer Research Group.

Of 48 patients with bladder tumors treated with intravesical epodyl 17 have shown a complete remission at some stage of treatment, although several have relapsed later. Partial remission occurred in 20 patients and 11 have shown no improvement or the lesions have progressed. Epodyl is used best as an adjunct to transurethral resection or diathermy of T1 bladder lesions. Even in patients who do not show complete remission epodyl may reduce the incidence of recurrence and the number of lesions. It is useful when rapid recurrence of T1 bladder tumors prevents control by resection or diathermy and it also is beneficial as an emergency measure to control hematuria. Complications are not infrequent and may be severe occasionally. Bone marrow depression has been seen in 2 patients whose bladders showed extensive carcinoma in situ.

Adult↗
PubMed1977

The rate of urine production and the isotope renogram.

The rate of urine production has been measured in a group of normal subjects undergoing renography. It has been helpful in assessing the results. Renograms look unusual at low flow rates and can be misinterpreted if the urine flow rate is not known.

Humans↗