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Biomedical subjects

B Prakash

Publications and source records attributed to B Prakash.

At least 37 records · Page 2Linked to original sources
PubMed1995

Optimum kinetic energy dissipation to maintain blood flow in glass capillaries: an analysis based on flow field determination by axial tomographic and image velocimetry techniques.

The video micrographic images of fully developed blood flow in a glass capillary of diameter 200 microns are recorded. These data after digitization are analyzed by an IBM PC/AT-based image processing system to obtain erythrocyte and velocity distribution profiles by axial tomographic and image velocimetry techniques, respectively. The results obtained show that the parabolic profile of erythrocyte distribution at hematocrit 10% becomes more blunt at 60%. A similar increase in bluntness at the various hematocrit is observed for the velocity profiles. For calculation of kinetic energy dissipation a set of erythrocyte distribution profiles at each hematocrit with a transition from existing to parabolic one by multiparametric analysis, are constructed. The results show that the existing profiles as obtained at all hematocrits dissipate minimum kinetic energy. Any deviation towards parabolic form leads to dissipation of higher amount of the energy.

Algorithms↗
PubMed1994

Crystallization and preliminary X-ray diffraction studies on a trypsin/chymotrypsin double-headed inhibitor from horse gram.

The Bowman-Birk family of proteinase inhibitors from seeds of leguminous plants usually have a molecular mass of 8000 to 10,000 Da. Horse gram (Dolichos bifloros or Macrotyloma uniflorum) seeds contain an unusual Bowman-Birk inhibitor of molecular mass 15,500 Da active against both trypsin and chymotrypsin. In order to elucidate its three-dimensional structure, its evolutionary relationship with the more usual Bowman-Birk inhibitors and to study the structure-function properties, this inhibitor has been purified and crystallized. The purified protein crystallizes easily under a variety of conditions in different crystal forms. Crystals obtained by precipitating the protein (3 to 5 mg/ml in 50mM Tris.HCl (pH 8.0)) with 5% ammonium sulphate and 2 to 3% PEG 4000 appear to be suitable for structure determination by X-ray diffraction. The crystals belong to cubic space group P2(1)3 (a = 110.81 A) and diffract X-rays to beyond 3.0 A resolution.

Chymotrypsin↗
PubMed1994

Cervical spondylosis: a review of 230 cases.

Between January 1981 and March 1991, 230 patients of cervical spondylosis were treated surgically. The choice of surgical approach was dependent on clinicoradiological presentation. Anterior discectomy was performed in 105 cases decompressive laminectomy in 119 cases and combined approach in 6 cases. In anterior discectomy group 89% showed improvement, 4% remained unchanged and 7% worsened. In decompressive laminectomy group 68% improved, 15% unchanged, 15% worsened and 1.6% died. In combined approach 66% showed improvement, 17% remained unchanged and 17% died. Anterior discectomy had less risk of overall complications than decompressive laminectomy.

Adult↗
PubMed1990

Magnetic resonance evaluation of spinal dysraphism in children.

Magnetic resonance (MR) imaging of the spine was performed as the initial imaging technique in 20 children when spinal dysraphism was suspected clinically and plain radiographs showed spina bifida. The correlation with surgical findings indicated that MR provided accurate information preoperatively in all the cases. Some unusual observations in cases with spina bifida cystica and occulta are discussed. It is concluded that plain radiograph and MR complete the preoperative radiologic evaluation of cases with spinal dysraphism.

Adolescent↗
PubMed1989

Intracranial aneurysms in India--microsurgical approach.

This is a retrospective study of 100 cases of intracranial aneurysms, treated in an Indian hospital, reflecting the special situation and experiences in our country. The incidence of subarachnoid haemorrhage due to ruptured aneurysm has been more or less the same as is reported from other parts of the world. The cases of recurrent haemorrhage resulting in poor clinical status are more common in our situation. Delayed referral and diagnosis were responsible for recurrent haemorrhage, increased morbidity and mortality. Forty two percent developed cerebral vasospasm within two weeks after the bleed. The use of a temporary clip on the parent vessel prevented the intraoperative rupture of the aneurysm while dissecting round about the aneurysm. Operative mortality was eight percent in the present series.

Humans↗
PubMed1989

Tuberculous abscess of the brain stem.

Three cases of tuberculous abscess of the brain stem were treated with excision of the abscess supplemented with antitubercular therapy for 12 to 18 months. The lesions were frankly purulent and tubercle bacilli were demonstrated in the pus. A computed tomography scan demonstrated the site and extent of the lesion. Two of three patients developed the abscess during the course of antitubercular therapy for associated tubercular lesions. In spite of modern antitubercular treatment the abscess did not resolve and surgical excision had to be employed as a curative treatment.

Abscess↗
PubMed1989

Human gnathostomiasis: infection with an immature male Gnathostoma spinigerum.

Gnathostomiasis, usually caused by larvae of Gnathostoma spinigerum, is a significant cause of morbidity in the Far East. We report a case of gnathostomiasis involving a male Thai residing in Kuwait who presented with acute pain in the right iliac fossa. A resection of the terminal ileum and cecum was performed. Microscopic examination showed a parasite in an eosinophilic abscess. The nematode was identified as an immature male G. spinigerum based on size, morphology, and distribution of cuticular spines.

Adult↗
PubMed1988

Computer assisted analysis of wound infection in neurosurgery.

The effect of 10 variables on the development of postoperative infection in 536 clean elective neurosurgery patients was calculated using correlational, regression and discriminant analyses. The time of shaving the operation site, type of theatre ventilation and duration of operation were found to have a highly significant effect on the infection rate. The influence of season and age of patient was not evident on simple analysis, but both were found to be significant factors using regression analysis. The sex of patient, carriage of Staphylococcus aureus, airborne bacterial count, presence of bacteria in the wound and the use of prophylactic antibiotics did not have a significant effect on infection rates.

Age Factors↗
PubMed1985

Surgical approach to large thalamic gliomas.

Fifteen cases of large thalamic gliomas were treated by laser surgery and CUSA under X8 magnification and subsequently they were subjected to radiotherapy. More than 50% of the tumours were located in the dominant hemisphere and therefore an interhemispheric approach was carried out to avoid disturbances of speech and field defects. Nine patients had astrocytomas grade II and the remaining six had astrocytomas grades III-IV. The quality and survival has been gratifying in the less malignant gliomas. The operative technique and use of Laser and CUSA is highlighted.

Adolescent↗