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Biomedical subjects

B Philipson

Publications and source records attributed to B Philipson.

At least 55 records · Page 3Linked to original sources
PubMed1975

Mucosal morphology, bacteriology, and absorption in intra-abdominal ileostomy reservoir.

Six patients who had undergone proctocolectomy and been provided with intra-abdominal ileostomy reservoirs were studied in intervals during the 24 postoperative months. The studies included the mucosal morphology, bacteriology, and the local absorption in the reservoir. The results showed that the mucous membrane of the terminal ileal segment used for construction of the reservoir underwent morphological changes characterized by an increased cell turnover and a shortening of the villi. These changes in morphological structure took place rather promptly after construction of the reservoir. No indications for a continuously progressing process could be found. The brushborder was intact and no cellular lesions were discovered. Soon after construction the reservoir was inhabited by a microbial flora which held an intermediate position between the flora of effluent from conventional ileostomies and normal faeces. The flora remained rather stable in the reservoir. In spite of the new microbial ecology and the morphological changes, the reservoir mucous membrane did retain absorptive capacity for D-xylose and phenylalanine.

Biopsy↗
PubMed1975

Morphology in the cat ileal mucosa following construction of an ileal reservoir or transposition of patches to different locations.

In an attempt to examine the response of the ileal mucosa to different noxious environments and to correlate the results with findings in human continent ileostomy reservoirs, cat intestine was subjected to various operative procedures: first, ileal reservoirs were constructed in continuity with the small intestine, a technique that was slightly different from that employed in human subjects, and secondly, segments or patches of ileum were transposed to the colon, the urinary bladder, or the jejunum. Morphometric evaluation was subsequently performed on these samples. The mucosa of the reservoir revealed a decrease in villus height accompanied by an increased mitotic index. Identical changes were observed when ileal segments or patches were inserted in the colon, whilst transposition to the urinary bladder resulted in similar but more pronounced alterations. When ileal patches from the colon or urinary bladder were replaced in the jejunum, the villi were once again enlarged. The epithelial cells remained normal in all cases except following transposition to the urinary bladder, where flattening of the cells or partial denudation of the villus tips was encountered. The changes observed represent a classical hyper-regenerative transformation of the mucosa, and correspond closely with the changes recorded in human continent ileostomy reservoirs. Furthermore, the reversibility of such alterations has been demonstrated. The experimental design permitted the exclusion of intraluminal pressure, dilatation, and nervous and vascular derangements as the cause of the transformation; it is concluded that the intraluminal environment is the factor most probably responsible for such structural alterations.

Animals↗
PubMed1971

Abortion studies in patients with "intraabdominal ileostomy reservoirs" and in patients with conventional ileostomies.

Twenty patients with ileostomy were studied concerning the absorption of d-xylose, fat, l-phenylalanine, and vitamin B(12). Ten patients had a conventional ileostomy, whereas 10 others were provided with an intraabdominal intestinal ileostomy reservoir resulting in faecal continence. No remarkable differences in the absorption of d-xylose, fat, or l-phenylalanine were found between the two groups of ileostomy patients. Most of the absorption values were within normal or borderline ranges. In the reservoir group the Schilling test gave subnormal values in six out of 10 patients, whereas only one patient in the group with a conventional ileostomy had a subnormal value. The reason for this finding is briefly discussed.

Administration, Oral↗