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Biomedical subjects

B Petersson

Publications and source records attributed to B Petersson.

At least 73 records · Page 4Linked to original sources
PubMed1984

Acute psychiatric admission related to the menstrual cycle.

A study of menstrual cycle phase on the day of acute admission to a psychiatric hospital for 121 women aged 20-39 showed an unequal distribution of admissions. More admissions than expected took place in the menstrual period, and correspondingly fewer intermenstrually. The difference was significant, and points to a certain degree of cyclicity in female psychiatric disturbance. This cyclicity was not significantly influenced by age, diagnosis, oral contraceptives or tendency for premenstrual symptoms. In the age group 20-39 one and a half times as many men as women are admitted to Danish psychiatric departments. Thus, in view of a common baseline, the most conspicuous feature is, that remarkably few women were admitted intermenstrually.

Acute Disease↗
PubMed1983

Raised serum urate concentration as risk factor for premature mortality in middle aged men: relation to death from cancer.

Low serum cholesterol concentrations are associated with deaths from cancer. This association was found in a prospective study of middle aged men in Malmö and consideration of possible explanations for the lowering of serum cholesterol prompted an analysis of serum urate in relation to deaths from cancer. A total of 127 of the 7725 participants in the Malmö study had died since screening. A weakly positive but significant correlation between raised serum urate concentration and total mortality was found. This correlation was wholly explained by neoplastic deaths (p less than 0.01), while there were no associations with alcohol related deaths or with deaths from coronary heart disease. When the deaths from cancer were classified as "early" or "late"--that is, occurring less than or more than 2.5 years after the screening--the correlation between raised urate concentrations and cancer mortality was confined to the "early" deaths (p less than 0.001). Further studies are needed to substantiate the relation between raised serum urate concentrations and fatal neoplasia. Nevertheless, these findings weigh against recent suggestions that uric acid has an antioxidant protective effect against cancer.

Body Weight↗
PubMed1982

Alcohol abstention and premature mortality in middle-aged men.

A series of middle-aged men were investigated for total mortality up to five years after completing a questionnaire on alcohol consumption administered during a preventive medical screening programme in Malmö, Sweden. The aim was to test the hypothesis that small amounts of alcohol are beneficial to general and cardiovascular health. Relative mortality was increased among the men who had reported non-use of alcohol in the screening questionnaire. Most of these men, however, had chronic disease as the reason for their abstention, or even a past history of alcoholism.

Alcohol Drinking↗
PubMed1982

Alcohol-related death: a major contributor to mortality in urban middle-aged men.

The role of alcohol abuse in mortality was studied in an unselected population of over 10,000 46-48-year-old men in Malmö, Sweden. During follow-up of 0-6 years (mean 3 years) 199 men died. In 61 men (30.7%) death was alcohol related. A theoretical calculation of excess deaths in men with an alcohol-positive history yielded 78 deaths (39.2%). In the official cause of death statistics 10 of the deaths had been assigned alcoholic aetiology (5.0%). These estimates indicate that alcohol was the commonest underlying factor in death in this sample of middle-aged men. The number of deaths with alcoholic aetiology in official cause of death statistics should be multiplied by a factor of six to eight to arrive at the true alcohol-related death rate.

Accident Proneness↗
PubMed1982

Preservation of morphology, insulin biosynthesis, and insulin release in cryopreserved human fetal pancreas.

Human fetal pancreatic glands were obtained from 12 consecutive prostaglandin-induced abortions. Explants cultured for 1 day were frozen at 0.3 degree C/min in a 1 M DMSO-containing medium and stored at -196 degrees C. After storage for 3-4 mo the frozen material was rapidly thawed and cultured 1 day before being tested for functional performance. There was a positive correlation between the pancreatic insulin content and the fetal crown-heel length. Seven of the twelve fetuses showed a marked insulin response to an acute glucose-theophylline challenge. In five of these pancreases there was a well-preserved morphology after thawing, whereas only one of the nonresponding preparations showed a satisfactory morphology. Pancreatic explants from three of four fetuses tested displayed evidences of an (pro)insulin biosynthesis. The combined results indicated that low-temperature storage of human fetal endocrine pancreas is compatible with specific functional survival.

Female↗
PubMed1981

Hormone content of mouse pancreatic islets subjected to different in vivo and in vitro functional demands.

Mice treated for 4 days with tolbutamide displayed decreased serum glucose values with a concomitant decrease of their islet insulin content. Mouse islets cultured for 1 week at a low (3 mM) or a high (28 mM) glucose concentration contained less insulin than non-cultured islets and islets cultured at a medium (11 mM) glucose concentration. All groups of cultured islets contained more glucagon than non-cultured islets. The somatostatin content of high- and medium-glucose cultured islets was higher than that of freshly isolated islets.

Animals↗
PubMed1981

Failure of successful intrasplenic transplantation of islets from lean mice to cure obese-hyperglycaemic mice, despite islet growth.

Implantation of allogeneic pancreatic islets encapsulated in Millipore diffusion chambers has been reported to normalize the obese-hyperglycaemic syndrome in mice. In the present study, both young and adult ob/ob mice remained hyperglycaemic and gained weight after intrasplenic implantation of 500 isogeneic islets isolated from lean mice. Such islets normalized the elevated blood-glucose of alloxan-diabetic lean mice. Morphometric analysis of the intrasplenically implanted islets showed that the mean islet volume in the ob/ob mice was five times larger than that of the lean, non-diabetic mice. Immunocytochemical staining of the spleens showed an increased proportion of B-cells in the enlarged, intrasplenic islets in the ob/ob mice. Moreover, autoradiographical examination of these islets demonstrated the presence of several labelled cells. These results suggest that the growth of the implanted "lean" islets is due to extrapancreatic factors which stimulate islet cell replication in the obese-hyperglycaemic mouse.

Animals↗
PubMed1980

Aneurysm of the popliteal vein as a cause of pulmonary embolism.

A case of recurrent pulmonary embolism, secondary to thrombosis in an aneurysm of the popliteal vein is described. The source of embolism was not obvious clinically, and it was discovered only after venography. The anomaly was amenable to surgical intervention and the patient was cured from his source of embolism. We have found only one similar case in the literature.

Adult↗
PubMed1980

Effects of short-term and prolonged infusions of somatostatin on endocrine pancreas, body weight and food intake in rats.

Infusion of cyclic somatostatin (700 mg/kg/min) for 4 h in rat fed and libitum suppressed basal insulin but not glucagon release. It was accompanied by hypoglycemia during the first hour whereas, at the end of the infusion, hyperglycemia was present. The same dose of somatostatin applied 60 min prior to and during a 30 min load of glucose or arginine significantly inhibited their effects on insulin and glucagon release. In contrast, when this dose of somatostatin was given during a 24 h period by the i.v. route it did not inhibit glucose induced insulin release though circulating somatostatin levels were constantly and markedly elevated. Furthermore, in rats continuously infused with somatostatin for 4 days, no effect was found either on plasma concentrations of glucose, insulin, glucagon, growth hormone and cyclic AMP, or on body weight gain, food consumption or water intake. The pancreases of these animals showed normal concentrations of insulin and glucagon and a normal nuclear area of D-cells. Our experiments demonstrate that, in short-term experiments in rats, somatostatin influences insulin and glucagon release as well as glucose homeostasis. Furthermore, they suggest that during prolonged i.v. administration of somatostatin, rats develop mechanisms counteracting the effect of the peptide, e.g., peripheral tachyphylaxis.

Animals↗