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Biomedical subjects

B Patterson

Publications and source records attributed to B Patterson.

At least 73 records · Page 4Linked to original sources
PubMed1990

Turn it around: short-term management for aggression and anger.

1. Although nurses are at considerable risk for assaults, there are few practical and specific guidelines for controlling anger and aggression. 2. A training course was developed to give staff the necessary skills and knowledge to cope with clients who have the potential to become angry and assaultive, or those who have already become violent. 3. Participants in the training course felt more confident in managing potentially violent situations, and they reported relying on methods to de-escalate the situation to halt a sequence that would ultimately lead to violence.

Aggression↗
PubMed1989

EBV and HSV infections in a patient who had undergone bone marrow transplantation: oral manifestations and diagnosis by in situ nucleic acid hybridization.

The course of infections with herpes simplex virus and Epstein-Barr virus in an immunosuppressed patient who had undergone bone marrow transplantation and had tested seronegative for human immunodeficiency virus is described. The clinical oral manifestations were unusual, as they included hairy leukoplakia-like lesions and extensive mucosal ulceration. Histologic examination disclosed unique features consisting of both lichenoid and viral cytopathic changes. The association of the lesions with both Epstein-Barr virus and herpes simplex virus was confirmed by in situ hybridization histochemistry. The importance of recognition of the symptoms, specific diagnosis by DNA hybridization, and implications for antiviral prophylaxis and therapy are emphasized.

Adult↗
PubMed1987

An essential yeast snRNA with a U5-like domain is required for splicing in vivo.

Yeast contains at least 24 snRNAs, many of which are dispensable for viability. We recently demonstrated that a small subset of these RNAs has a functional binding site for the Sm antigen, a hallmark of metazoan snRNAs involved in mRNA processing. Here we show that one of these snRNAs, snR7, is required for growth. To determine the biochemical basis of lethality in cells lacking snR7, we engineered the conditional synthesis of snR7 by fusing the snRNA coding sequences to the yeast GAL1 control region. Cells depleted for the SNR7 gene product by growth on glucose for five generations show marked accumulation of unspliced mRNA precursors from the four intron-containing genes tested. In some cases, intron-exon 2 lariats also accumulate. We have identified a 70 nucleotide domain within snR7 with limited sequence-specific but striking structural homology to the mammalian snRNA U5. We conclude that mRNA splicing in yeast requires the function of a U5-like snRNA.

Base Sequence↗
PubMed1987

Hepatic candidiasis: an increasing problem in immunocompromised patients.

Hepatic candidiasis has been increasingly recognized as a variant of disseminated candidiasis in immunocompromised patients. Five leukemic patients with antemortem diagnosis of hepatic candidiasis are described, and 32 additional cases reported in the literature are reviewed. Cultures of the liver and/or spleen and blood cultures usually give negative results; histopathologic demonstration of Candida organisms in tissue specimens is necessary for a definitive diagnosis. Response to conventional therapy with amphotericin B is poor, and 34.4 percent of the patients died with evidence of active fungal disease. Liposome-encapsulated amphotericin B, which has been successfully used in a limited number of patients with invasive fungal disease, may be an effective and relatively nontoxic drug.

Adult↗
PubMed1987

A method for predicting accrual, cost, and paper flow in clinical trials.

We consider a mathematical model for accrual and costs associated with randomized clinical trials. A model that predicts the cost as a function of time can be constructed from the design assumptions of the trial and estimates of per patient costs of recruitment, treatment, and follow-up. Our notion of cost is a general one and includes personnel and paper flow as well as money. Costs associated with accrual and follow-up are distinguished in order to more accurately model per patient expenses. We assume that the investigator will specify these expenses in the same fashion that accrual and survival rates are estimated for statistical design. The size of the patient population to be followed can then be modeled and used to estimate cost. Although relatively simple cost equations result for the assumptions of constant accrual and exponential survival, very general assumptions can be incorporated into the model. The model has the advantages of predicting the time course of costs, allowing for different accrual and follow-up costs, and being amenable to revision during the conduct of a trial. Examples of cost modeling in a lung cancer clinical trial and cost minimization are offered.

Clinical Trials as Topic↗
PubMed1983

cAMP in guinea-pig superior cervical ganglia during preganglionic nerve stimulation.

Preganglionic nerve stimulation or elevated [K+]o increase cAMP levels in isolated guinea-pig superior cervical ganglia, a ganglion lacking adrenergic inhibitory synaptic potentials. The cAMP response to K+ and nerve stimulation is not prevented by atropine or phentolamine. The regulation of cAMP content does not involve cholinergic or adrenergic mechanism. Of polypeptides tested, only VIP (5 X 10(-6) M) increases cAMP content to the extent observed with preganglionic nerve stimulation.

Animals↗
PubMed1967

Hominid humeral fragment from early Pleistocene of northwestern Kenya.

The distal end of a hominoid humerus was recovered from early Pleistocene sediments in the Kanapoi drainage near the southern end of Lake Rudolf. Lava capping the sediments yielded a potassium/argon date of 2.5 million years. The fragment can be distinguished on inspection from gorilla and orangutan; discriminate analysis of humeri of Homo and Pan assigns it as hominid. From other evidence we consider it more likely to represent Australopithecus s.s. than Paranthropus.

Anatomy, Comparative↗