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Biomedical subjects

B P Moore

Publications and source records attributed to B P Moore.

At least 73 records · Page 4Linked to original sources
PubMed1975

Hepatitis B antigenemia among blood donors: the changing scene.

For the period May 1973 to August 1974 inclusive, the mean prevalence of hepatitis B antigenemia (HBsAg) in all Canadian provinces (per 100,000 population) was, for "first-time" donors, 242 and, for "repeat" donors, 77. A modification of counterimmunoelectrophoresis was used in all 16 regional transfusion centres. The findings confirm the previously noted high prevalence for the Province of Québec and the continuing relatively high prevalence for Canada. The prevalence of HBsAg among donors could be lessened by institution of the following measures: development of a more effective technique for the screening of hepatitis carriers, study of nonparenterally transmitted hepatitis, better reporting of post-transfusion hepatitis, and greater discrimination in prescribing blood and blood components.

Blood Donors↗
PubMed1975

Operative stabilization of nonpenetrating chest injuries.

Since 1958, a series of 112 patients with severe or moderately severe chest injuries have been treated. An aggressive policy has been adopted toward correcting or preventing major paradoxical chest wall movement by intramedullary pinning of ribs, costal cartilages, and the sternum. Whenever possible, positive-pressure mechanical ventilation and tracheostomy have been avoided. Fifty patients underwent stabilizing operations. The surgical approach was anterolateral in 12 (average 3.3 pins), posterolateral in 35 (average 6.8 pins), and midsternal in 3. Tracheostomy was performed in 8 of these 50 patients. Three died, on the first, third, and twenty-fifth days after injury. The tracheostomy was used only for aspiration of secretions in 3 others and for postoperative intermittent positive-pressure ventilation in 2 others. The duration of intermittent positive-pressure ventilation was 14 days and 1 day, respectively, Orotracheal intubation with positive-pressure mechanical ventilation after operation was required for more than a few hours in 3 patients, 1 of whom died. The 2 survivors were ventilated for 1 and 5 days. There was a total of 11 hospital deaths in these 50 cases. However, in 2 patients the severity of the initial injuries was thought to make death inevitable. Three of the patients who died were over 70 years of age. Operative stabilization permits avoidance or reduction in the duration of tracheostomy and mechanical ventilation. Permanent chest wall deformity is lessened or avoided.

Adolescent↗
PubMed1970

Proficiency in the detection and titration of blood group antibodies: results of an interlaboratory trial.

Twelve numbered samples of serum were distributed to 82 Canadian blood transfusion laboratories. The presence or absence of blood group antibodies in these samples was correctly reported by less than 50% of participants; inability to demonstrate the presence of weak anti-D or anti-c was responsible for most of the failures. On the other hand, about 85% of participants reported titres of anti-D and anti-Fy(a) within an acceptable range. Two proposals are made that should help laboratories achieve a high and uniform level of proficiency in antibody detection and titration.

Antibodies↗
PubMed1970

Automation in the blood transfusion laboratory. 3. Use of the autoanalyzer in a prenatal consultation program.

A Technicon AutoAnalyzer hemagglutination system was used to test sera from 1388 prenatal patients. This automated approach to antibody screening was slightly more successful than careful hand tests. Estimates of anti-D concentration on the AutoAnalyzer correlated well with antiglobulin titres and compared favourably with hand titres in indicating those cases requiring examination of amniotic fluid. Once other large-scale studies establish what levels of anti-D are clinically significant, apparatus of the type described should be of considerable practical value in routine prenatal work.

Amniotic Fluid↗