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Biomedical subjects

B P Moore

Publications and source records attributed to B P Moore.

At least 19 recordsLinked to original sources
PubMed1992

TSEN: a novel MNS-related blood group antigen.

We report an antibody (anti-TSEN) that recognizes an antigen (TSEN) at the unique amino acid sequence that results from the junction of GPA58 to GPB27 if the GPB carries the S antigen. Red cells from several unrelated donors that possess this specific GP(A-B) hybrid molecule were agglutinated by anti-TSEN. Since a synthetic peptide with the amino acid sequence at this junction (Pro-Glu-Glu-Glu-Thr-Gly-Glu-Met-Gly-Gln-Leu-Val-His-Arg) specifically inhibited anti-TSEN, it must detect an antigen within this novel amino acid sequence. The TSEN antigen has been provisionally assigned the MNS blood group system number 002.033 on behalf of the ISBT Working Party on Terminology for Red Cell Surface Antigens.

Adult↗
PubMed1988

Two examples of a new low-frequency red cell antigen, JFV.

A new low frequency red cell antigen JFV has been found in two families, one of German and one of Dutch origin. JFV is inherited as an autosomal dominant character. Family studies showed that JFV is not controlled by the Rh, MNS, Lu, Fy, or Jk loci and that it is not X- or Y-borne.

Female↗
PubMed1988

Replicate tests for the detection and correction of errors in anti-human globulin (AHG) tests: optimum conditions and quality control.

Replicate blind AHG tests with weak IgG anti-D sensitised red cells revealed that 32% of workers caused 5 per cent or more false negative errors by using excessive agitation in reading techniques. The common quality control procedure of adding strongly sensitised cells to all negative AHG tests cannot reveal this type of error. Furthermore, strongly sensitised control cells may create an illusion of safety because AHG giving a false negative test with weak antibody in a serum sample may still show a reassuringly strong positive in the control test. "In-house" assessment of all staff and automatic cell-washers by blind replicate tests is recommended as an effective way of improving AHG test performance, thus reducing many of the errors involving false negative AHG tests seen year after year in External Proficiency Trials.

Antibodies↗
PubMed1986

RASM, a "new' low-frequency blood group antigen.

A 'new' low-frequency red cell antigen, RASM, was found in 3 generations of a Caucasian family. It is inherited as a Mendelian dominant character. The propositus, a newborn, had a positive direct antiglobulin test; overt haemolytic disease of the newborn was not present.

Antigens, Surface↗
PubMed1986

A family demonstrating inheritance of the Leach phenotype: a Gerbich-negative phenotype associated with elliptocytosis.

The proposita of a Canadian family and 2 of her sibs have the rare Leach phenotype and provide the first evidence that the Leach phenotype is an inherited condition. Their red cells are Ge: -2, -3 and fail to react, by the antiglobulin test, with the monoclonal antibodies GERO, BRIC 4 and BRIC 10. The minor sialoglycoproteins beta, beta 1 and gamma are apparently absent from their red cell membranes. A proportion of their red cells are elliptocytes indicating that beta and/or beta 1 and/or gamma have a function in maintaining normal red cell shape.

Antibodies, Monoclonal↗
PubMed1986

Good laboratory practice before and after blood transfusion.

Among the general principles that govern good laboratory practice before and after blood transfusion, there are two aspects which receive little attention: the importance of transfusion medicine as a distinct discipline; and the interrelationships within the hospital needed to make the "Blood Bank" effective.

Blood Banks↗
PubMed1979

Prevalence of HBsAg and HBsAg sub-types in the Canadian blood-donor population.

After 8 years of screening all blood donations in Canada for HBsAg, first by CIEP and later by RIA, the prevalence of HBsAg in the regular panel of "repeat" donors has been reduced from 267/10(5) to 39/10(5). Marked geographic variations exist, but the available data do not indicate whether the high prevalence of HBsAg in young adults, particularly males, may be a factor. The ad : ay subtype ratio across Canada is 2.0, but noticeable geographic differences are present, varying from 3.5 in Quebec to 0.5 in the Atlantic Provinces.

Aging↗