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Biomedical subjects

B N Kholodenko

Publications and source records attributed to B N Kholodenko.

76 records · Page 5Linked to original sources

[Optical tactics of antibacterial therapy for the trigger model of the infection process].

A problem is considered on optimal concentration of an antibacterial drug for the model of illness, in which the illness and health states of the host organism are identified with alternative stationary states of pathogenic microbe population. The total toxic effect of the drug and pathogenic microbes is minimized. The optical tactics is shown to depend first of all on the growth pattern of the drug toxic effect with the increase of its concentration. If the function approximating this relationship is arched upwards (small rise of the toxic effect) the maximal tolerable concentration of the drug is the optimal one. In other cases the "typical" optimal tactics is that under which the concentration of the drug in the beginning of treatment rapidly increases up to the maximal tolerable one, is maintained at this level for some time and then monotonously decreases to the end of treatment for a long time.

Anti-Bacterial Agents↗

[Biochemical individuality of humans and invariants of regulation. Scale invariance of the characteristic of glycolysis in erythrocytes].

The problem of the investigation of the metabolism regulation features, which are independent of the individual variance in biochemical parameters is formulated. The glycolysis characteristic of erythrocytes which is the ATP concentration dependence of the stationary rate of the ATP production is in fact dependent also on the many individual parameters of the erythrocyte (the enzyme activities, the total sum of adenine nucleotides and so on). It is shown that this function of many variables can be effectively factorized into an universal function of the relative ATP concentration (i. e. ATP/(AMP+ADP+ATP)) and some functions of individual parameters.

Adenosine Diphosphate↗