Biomedical subjects
Publications and source records attributed to B Mihout.
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Visual evoked responses to flash pattern simulations have been observed in young healthy adults. Stimulations of whole visual fields (37 subjects) and half-fields (11 subjects) have been performed. These responses are reproductible from one subject to another and show very clear waves in the occipital and central regions. On central leads, whatever the stimulation (stimulation of total visual fields or half-fields), the responses are always the same: a negative peak at 70 msec. followed by a positive peak at 90 msec, then a negative peak at 116-120 msec. On occipital leads, stimulation of the whole visual field shows a diphasic response: a positive wave at 100 msec and a negative wave at 140-150 msec. However, half-field stimulation shows different responses on the ipsi- and contralateral hemispheres, with a disappearance of the positive 100 msec wave in the ipsilateral occipital region. Thus, flash pattern stimulations seem to be useful in clinical practice because they evoke different types of responses in occipital and central regions.
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Non edematous cerebellar softenings are usually unrecognized even though their relatively high frequency of occurrence is proved by systematic anatomical studies. They should be suspected when an acute late-onset vestibular syndrome is noted, in which there is a particular type of homolateral disequilibrium and nystagmus, good vestibular reactivity, and possible association with a cerebellar syndrome. Softening can usually be confirmed after several days by the complementary examinations presently available: computer tomography of the posterior fossa and scintigraphy with labelled bleomycin. Non-edematous forms are spontaneously resolving disorders but surveillance during the first few days is necessary together with anti-edematous therapy as early signs are common to those of edematous softening, responsible for rapid involvement of the brain stem and blocking of fluid pathways.
A comparison is made between cerebral evoked potentials through the left and right eye by studying the correlation functions between the two visual responses obtained. Two values were retained: the correlation coefficient CO which shows the degree of similarity between the two curves, and the phase displacement D which indicates the duration for which a curve has to be shifted in relation to the other in order to resemble it as closely as possible. An original representation, in the form of a correlation/phase displacement diagram, is drawn for each subject, and enables easy separation of normal subjects from those with pathological conditions. This technique was applied to 20 normal subjects acting as controls and 40 patients with suspected or confirmed multiple sclerosis. In the latter group, anomalies were found in 67 p. cent whereas retrobulbar optic neuritis had been diagnosed in only 35 p. cent of cases. By reducing the sample to include only known or probable cases of MS, anomalies were found in 88 p. cent with retrobulbar optic neuritis known in only 51 p. cent. These results are comparable with those obtained by using previously described methods, but have the advantage of automatic readings which are completely objective.
A nineteen year old man present an original clinical case of acute cerebellitis in infectious mononucleosis. Eighteen months after the acute phase of the illness, there persisted a large deficit in the circulating B lymphocytes. A short review of pertinent litterature is presented and current physiopathological hypothesis are discussed. Briefly, delayed immunity and personal predisposition appear to play important etiological roles.
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A patient suffering from essential thrombocythemia presented manifestations of digital thromboses and two cerebral ischemic strokes. Anomalies of platelet function are discussed in relation to published data and the efficacy of antiaggregant treatment is stressed.
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The authors report a case of IgD myeloma of which the initial symptom was a mononeuritis and the biological, immunological and ultrastructural study performed about this case. Then are reviewed the mechanisms, proved or hypothetical, by which are actually explained the event of neuropathies within lympho-plasmocytic disorders.
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