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Biomedical subjects

B Magnani

Publications and source records attributed to B Magnani.

At least 289 records · Page 16Linked to original sources
PubMed1979

[Atrioventricular canal associated with Fallot's tetralogy. Anatomo-clinical study of 2 cases].

The Authors are examing two cases of A-V canal associated with T. of Fallot. The most important clinical aspects of this rare cardiopathy result in the following: -- the frequent coexistence with Down dyndrome; -- the ECG and VCG aspects of counterclockwise rotation of the initial vectors of QRS in the frontal plane; -- the simultaneous observation of the typical echocardiographical aspects of both kinds of cardiopathy. The injection of dye into both ventricles allows the precise diagnosis. The post-mortem study in both cases shows the morphology of A-V canal associated with the one of T. of Fallot. From the surgical point of view it is important to take into account the abnormal morphology and extension of VSD. The importance of the part that the conal cushion plays in the morphogenesis of the malformation is discussed.

Adolescent↗
PubMed1979

Evaluation of clinical efficacy and plasma levels of aprindine.

The clinical efficacy of Aprindine, a new antiarrhythmic agent was tested in 37 patients with ventricular and supraventricular arrhythmias. The drug was shown to be effective - disappearance or prevention of relapse of the arrhythmia - in 80% of the cases with ventricular tachycardia, and in 67.7% of the cases with premature ventricular beats. No judgement was possible for supraventricular tachycardia due to the small number of patients. Effectivness of Aprindine was found to be related more closely to the administered dose expressed in mg/kg body weight than to plasma level in steady-state. Discontinuation of therapy was necessary in 5 cases due to the appearance of side effects (tremor and dizziness). Side effects were not found to be in relation with plasma levels or administered dose. In the period of observation (2 months) no effects on blood cells were noticed.

Adult↗
PubMed1979

Total body potassium and long-term treatment with amiloride HCL and/or hydrochlorothiazide.

The potassium sparing effect of 5 mg of amiloride (A) given either alone, or in combination with 50 mg of hydrochlorothiazide (HCTH) was evaluated in 23 patients with essential hypertension on a daily diet containing 70 mEq of K and 130 mEq of Na. Two studies were carried out. In the first, patients received HCTH alone (2 months) followed by A alone (2 months) and the two combined (6 months). The results of this study demonstrate that A is capable of correcting and preventing the loss of serum and total body potassium (TBK) and of reducing the increase of serum uric acid induced by HCTH. In the second study, each patient received from the beginning A + HCTH for 12 months; no statistically significant changes for serum and total body potassium and for serum uric acid appeared in any patient after six and twelve months. This study proves that A is capable of clinical potassium sparing effect in hypertensives and that this effect is a long lasting one.

Amiloride↗
PubMed1979

Side effects of antihypertensive drugs. Incidence and methods of collection.

A prospective study has been carried out in two groups of hypertensive patients (482 inpatients followed during 2-3 weeks; 120 outpatients followed for 18 months) to evaluate the prevalence of side effects (SE) induced by antihypertensive drugs in current use. Only SE of definite or probable type as operatively defined were taken into consideration. SE were collected in different ways for inpatients and outpatients. Among 120 outpatients, 30 patients were randomly selected for cross over of placebo and drugs. Definite or probable SE were recorded in 236 (48.9%) of 482 patients: the prevalence of SE was below 20% both in single and multiple drug therapy. A prevalence greater than 20% was recorded in the outpatients. The placebo treatment demonstrated that many SE are not related to drug administration.

Antihypertensive Agents↗
PubMed1979

[Comparison of the hemodynamic effects induced by dobutamine, isoproterenol and dopamine in patients with coronary artery disease (author's transl)].

The haemodynamic affects of dobutamine (DB) (5 microgram/kg/min), isoproterenol (I) (0.02 microgram/kg/min), dopamine (DP) (5 microgram/kg/min), were studied in 12 patients with coronary artery disease randomly divided in two groups of 6 patients. In one group each patient received DB and I, in the other group each patient received DB and DP. The following parameters were measured: heart rate, aortic blood pressure, left ventricular pressure, left ventricular dp/dt, pulmonary arterial and wedge pressure, cardiac output, stroke volume, peripheral and pulmonary vascular resistances. In both groups either I and DP increased significantly heart rate whereas DB did not modifie it. DB caused a larger increase of dp/dt max and of stroke volume as compared to I and DP. These data confirm that DB possesses an inotropic effect greater than I and DP without any significant positive chronotropic effect in patients with coronary artery disease.

Adult↗