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Biomedical subjects

B Magnani

Publications and source records attributed to B Magnani.

At least 271 records · Page 15Linked to original sources
PubMed1981

[Precordial mapping of the QRS complex and Frank's orthogonal ECG in evaluation of the myocardial infarct area. Comparison of the 2 methods].

Precordial mapping of QRS complex is a reliable tool in attempts to quantitate infarct size in patients with acute myocardial infarction. However the recording of multiple precordial leads is an expansive and time-consuming process; the purpose of this study is to investigate the usefulness of Frank's ECG as a substitutive method of infarct sizing. In a group of patients with acute myocardial infarction of the anterior wall many repeated precordial mappings with simultaneous recording of x, y, z leads of Frank's ecg were obtained (71 observations as a whole). Parameters provided by precordial mapping [delta R, delta Q, delta R + delta Q, delta R/delta (Q + S)] and by Frank's ecg (spatial vector voltage deviation of QRS or VSDV-QRS; spatial vector area deviation of QRS or VSDA-QRS; spatial vector R wave deviation or VSDR) were correlated each other by means of linear regression analysis. delta R + delta Q correlated significantly with VSDA QRS (r = 0.54; p less than 0.001) and with VSDR (r = 0.55; p less than 0.001) as regards the total of observations. The correlation coefficient was higher (r = 0.8; p less than 0.001) if comparison between delta R + delta Q and VSDA-QRS was restricted to early 48 hours from the beginning of the symptoms. This could be explained by the greater entity of QRS complex changes in this period, compared to the subsequent course. We conclude that Frank's ecg is an useful alternative method to precordial mapping in sizing the extension of myocardial necrosis.

Electrocardiography↗
PubMed1981

[Rupture of interventricular septum and ventricular aneurysm secondary to acute myocardial infarction in a case with normal coronary arteries (author's transl)].

A patient with ventricular septal defect and ventricular aneurysm after an acute myocardial infarction with normal coronary arteries is reported. Heart failure at 3 weeks after acute myocardial infarction was the indication for surgical treatment. The patient was successfully operated upon with resection of the aneurysm and closure of the ventricular septal defect. Coronary angiography performed before and after cardiac surgery demonstrated a normal coronary tree with transient systolic subocclusion of the left anterior descending coronary artery. The implication of a muscular bridge on the complications of myocardial infarction are discussed.

Heart Aneurysm↗
PubMed1981

Comparison of antihypertensive activity of atenolol and methyldopa at rest and during exercise.

In a double-blind, cross-over trial, 37 hypertensive patients were treated in random order, after a 4-week run-in period, with 100 mg atenolol in a single daily dose, or 250 mg methyldopa three times daily (or 500 mg three times daily in case of poor response). Both therapeutic regimens significantly reduced blood pressure (13/13 mmHg for atenolol and 17/10 mmHg for methyldopa) in an erect position. The higher dose of methyldopa gave a further significant reduction only for the systolic standing blood pressure. No statistical difference was found between the antihypertensive activity of the two drugs, but atenolol reduced heart rate more than did methyldopa. Side effects occurred more frequently during methyldopa administration and most often during the first days of treatment. During exercise (treadmill test) the two drugs induced the same antihypertensive response, but atenolol provoked a greater reduction of exercise tachycardia. Whereas total oxygen consumption was not affected by the two drugs, atenolol induced a much greater reduction of the myocardial oxygen consumption evaluated by the product of the systolic blood pressure X heart rate. These findings show that atenolol at the 100-mg daily dose is as effective as the full dosage of methyldopa and in addition shows better tolerance, a simpler therapeutic scheme, and less incidence of side effects.

Adult↗
PubMed1981

Effects of tienilic acid used alone and in association with triamterene or amiloride on urinary excretion of electrolytes.

The K-sparing effects of amiloride (A) and triamterene (T) associated with tienilic acid (C) are studied, along with their effects on diuresis and on the urinary excretion of uric acid, Mg, Na, Cl, P, and Ca. Eighteen hospitalized patients, divided into two groups of nine, received the following dosages of the drugs. The first group took 250 mg of C (equivalent to 50 mg hydrochlorothiazide), 5 mg of A and 100 mg of T; the second received double doses of both A and T but the same dose of C. Each treatment was administered on 2 not necessarily consecutive days, so as to have a total of 6 days of treatment per patient according to a balanced randomized design identical for the two groups. The data were obtained from urine collected during the first 8 h after the drug was administered, and during the following 16 h. A and T showed a significant K-sparing effect (p less than 0.01) only for the second group, and only at the higher dosages were minor effects on the urinary excretion of uric acid, Mg, and Cl noted (p less than 0.05). The association of A or T with C was well tolerated, and no important side effects were observed.

Amiloride↗
PubMed1980

Stress and distress in essential hypertension.

A consecutive unselected series of 20 outpatients suffering from essential hypertension is included in this study. These patients were compared to a control group of 20 patients other than hypertensives, matched for age, sex, marital status, years of schooling, social class and duration of illness. Stressful life events prior to illness onset, psychological distress as measured by SCL-90, and alexithymia were investigated. Patients with hypertension were exposed to undesirable life events before disease onset and exhibited alexithymic traits significantly more than the control group.

Adult↗
PubMed1980

[Tetralogy of Fallot associated with total anomalous pulmonary venous drainage. Case report (author's transl)].

A case of a 12 year old girl who presented tetralogy of Fallot (T. o F.) associated with Total Anomalous Pulmonary Venous Drainage (TAPVD) is described. This association is extremely rare, only four autopsied cases being reported in literature. TAPVD is associated with complex cyanotic congenital heart diseases in about one third of cases; asplenia or polysplenia are generally present. Double outlet right ventricle (DORV) is the commonest trunco-conal malformation associated with TAPVD; extremely rare is T. o F. Pulmonary outflow tract obstruction can avoid the haemodynamic consequences due to obstruction on the venous channel, or progression to pulmonary hypertension. The association of the two malformations can masquerade the clinical and Xray picture of TAPVD and make difficult the diagnosis during cardiac catheterization.

Cardiac Catheterization↗
PubMed1979

Intralymphocytic sodium in hypertensive patients: a significant correlation.

1. Intralymphocytic sodium concentration was measured in 50 patients with essential stable hypertension, 44 patients with labile hypertension and 40 subjects with normal blood pressure. 2. Intralymphocytic sodium concentration in normotensive subjects was significantly lower than in the other two groups. 3. The concentration was significantly correlated with mean blood pressure in the group as a whole and in the groups with stable and with labile hypertension. No correlation was found in normal subjects.

Blood Pressure↗