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Biomedical subjects

B Madea

Publications and source records attributed to B Madea.

At least 109 records · Page 6Linked to original sources
PubMed1986

[Postmortem transport of gastric contents?].

For the determination of the time since death, the distribution of the last meal in the stomach and small bowel may be of great importance. It may be even more difficult to estimate the time if there is a possibility that postmortem peristaltic emptying of the gastric content occurs, as has been claimed. Radiological control immediately after death by means of applying barium sulfate to the stomach, however, revealed no evidence of peristaltic emptying of the gastric content after death.

Animals↗
PubMed1986

[Priority of multiple gunshot injuries of the skull].

In accordance with Puppe's rule, the analysis of skull fractures may provide evidence on the sequence in which multiple blunt injuries of the skull occurred. In cases of multiple gunshot wounds of the skull determination of the sequence in which the gunshot wounds took place is much more difficult. In some cases, however, analysis of the skull fractures here can also allow the order in which gunshot wounds occurred to be established.

Adolescent↗
PubMed1985

[Determination of the time of death--integration of various partial methods].

The criteria for estimating time of death, lividity and rigor mortis according to data worked out by Mallach, together with data concerning the mechanical excitability of skeletal muscles (Prokop), the electrical excitability of face muscles and pharmacologic excitability of the iris (Klein and Klein) were combined with a nomogram of the rectal/brain temperature at time of death to make a rational and practical method of estimating time of death that would be suitable for use at a scene of crime. In each actual case, only a few additional criteria can be used to verify the upper and lower limits of the nomogram readings and to reduce these defined limits. For this reason the outer data from Mallach's tables and Klein's results were separated into upper and lower limits, chronologically arranged and clearly presented. After rectal temperature measurement and corresponding nomogram reading, it is easy to recognize which further criteria must be examined. Analysis of the test results is extremely simple with the aid of the proposed chart.

Body Temperature↗
PubMed1985

[Historical aspects of the determination of the time of death].

The origins of the determination of the time of death are presented with special reference to the signs of death, rigor mortis and body cooling, as well as to the supravital electrical response of skeletal muscle. The systematic method for future research resulting from these old experiments is presented, with the aim of making a more precise estimation of the time of death by standardization of the influencing factors.

Europe↗
PubMed1985

[Characterization of microtraces of blood].

The stains produced from micro-blood-drops (blood volume 0.2 microliter) on different substrate materials were examined with respect to morphological characteristics. Micro-stains made on paper showed the same general pattern as larger (macro-)bloodstains on the same substrate. The use of shirt material as substrate, however, resulted in differences in the stain pattern, particularly a greater variation within otherwise identical series. In addition when the angle of the bloodstains was acute, a variable number of smaller stains became detached. In these cases definite criteria can still be found for a description of bloodstains and for estimating the approximate angle of impact.

Blood Stains↗
PubMed1984

[Supravital electrical excitability of muscles].

A new method of postmortem electrical stimulation of muscles, measuring the force of the reaction against time, is presented. Preliminary investigations have yielded the following results: The maximum force of reaction in response to a definitive stimulation, measured by a sensitive force transducer, decreases in proportion to the post mortem interval. Using this method, the mechanical reactions of muscles by electrical stimulation can be demonstrated over a much longer postmortem period as these movements are visible. The duration of postmortem reaction of different muscles seems to be much more uniform than was previously assumed. Occasionally, reactions of the M. orbicularis oculi can be seen for the longest time. The basal muscular tonus changes relative to time. The time course of a single force reaction also changes relative to the postmortal interval: the reaction becomes slower. It has been theoretically established that measurement of influencing factors such as temperature and pH in the tested muscle will enable the time of death to be more precisely estimated.

Electric Stimulation↗
PubMedDate not supplied

Estimating time of death from measurement of the electrical excitability of skeletal muscle.

Post-mortem contraction was measured using sensitive force transducers inserted into human muscle. The muscle was stimulated using rectangular impulses of 1 sec duration and known current intensity. After some time, a noticeable change of the muscular contraction occurred, from a two-peak to a one-peak shape. The maximum force of the muscular contraction using a stable current intensity decreased with time since death, but relaxation time increased. The decrease of the maximum force and the increase of the relaxation time were used as criteria for extrapolating the time since death in a random sample of 50 bodies. The calculated 95% limits of confidence were 2.85 h (decrease of the maximum force) and 2.7 h (increase of relaxation time) up to 13 hours post mortem. The calculated 95% limits of confidence were checked on an independent sample of 21 bodies and proved to be reliable.

Adolescent↗
PubMedDate not supplied

[Suspected SIDS and diagnosis of myocarditis].

BACKGROUND: During the last years immunohistochemical techniques have improved the diagnosis of myocarditis using specific markers for quantification of leucocytes and characterization of T-lymphocytes together with the definition of MHC class II Antigens (HLA-DP, DQ, DR), known to be enhanced in cases of myocarditis. These techniques allow the diagnosis of myocarditis in an early stage of the inflammatory process in contrast to the conventional diagnostic with hematoxylin-eosin. MATERIALS AND METHODS: 20 autopsy cases were examined in a retrospective study with conventional histological and immunohistological methods. After routine investigations including toxicological and histological examination of internal organs all cases were considered as cases of Sudden Infant Death Syndrome (SIDS). RESULTS: Increased number of LCA-positive leucocytes and CD-3-positive T-lymphocytes together with enhanced expression of inflammatory marker leads to the diagnosis of a lymphomonocytic myocarditis in three cases, in one case myocarditis could be diagnosed by conventional hematoxylin-eosin staining. In one of these four cases of myocarditis a positive immunohistochemical reaction was found using a new antibody against enteroviruses. CONCLUSION: Immunohistochemical techniques improve diagnosis of myocarditis in cases of suspected sudden infant death syndrome. Further studies using immunohistochemical inflammatory markers to control the incidence of acute myocarditis are necessary.

CD3 Complex↗
PubMedDate not supplied

Rapid analysis of halothane in biological samples using headspace solid-phase microextraction and gas chromatography-mass spectrometry--a case of a double homicide.

A simple, rapid, and sensitive method for the analysis of halothane in biological samples was developed. The procedure describes the extraction of halothane from blood, liver, kidney, brain, urine, bile, and stomach contents by headspace solid-phase microextraction (HS-SPME) followed by capillary gas chromatography coupled with mass spectrometry (GC-MS). The recovery in blood samples after addition of ammonium sulfate and sulfuric acid was 72% compared to a sample prepared in water (100%). Linearity was established over a concentration range of 0.1-100 mg/kg of spiked blood samples with an excellent coefficient of correlation (0.996) and a limit of detection of 0.004 mg/kg. The time for analysis was approximately 40 min per sample including the extraction step. The procedure was used for quantitation of halothane in various samples in a case of a double homicide. HS-SPME in combination with GC-MS was an effective method for the determination and quantitation of halothane in biological material.

Aged↗
PubMedDate not supplied

[Reasons, circumstances and results of repeat forensic medicine autopsy].

There are only scant literature data on reasons and circumstances of medico-legal second autopsies. The present study includes 12 second autopsies from the period 1992-1997; the first post-mortem examination took place either in the home country (institutes of pathology) or abroad. 7 of the 12 cases of death investigated happened in Germany (exclusively in hospitals) and 5 of them abroad (Netherlands, Romania, Portugal, Libya). Repeat autopsies were ordered by criminal courts (n = 9), private persons (n = 2) and social insurances (n = 1). The main indication was possible medical malpractice (n = 6); acts of violence (n = 3), insurance questions (n = 2) and accidents (n = 1) followed. The time lapse between death and second autopsy was 2-35 days. It was striking, that German institutes of pathology had partially performed autopsies despite the certification of a non-natural death. Clinical autopsies were stopped twice, when evidence of a possible non-natural death occurred. It could be fundamentally stated, that first autopsies in German institutes of pathology had been carefully performed and sufficiently documented. In these cases the second autopsy presented no or only little additional information, as far as the broader taking of (toxicological) samples is not considered. The final medico-legal expertise was then mainly based on the findings of the clinical first autopsy. However, the concurrence of the forensic expert (instead of the clinical pathologist) is undoubtedly essential for the evaluation of these issues involving frequently questions of malpractice. By contrast, the quality of postmortems performed abroad varies widely. 4 of the 5 first autopsies done abroad were regarded as completely or partly insufficient with superficial or almost absent preparation of organs or contradictions in the medical reports, respectively. A repeat autopsy is absolutely necessary in such cases. On the whole, the initial question could be answered in all second autopsies at least in part. This emphasizes the high value of second autopsies and expertises, especially in non-natural cases of death (10 of 12 deaths were finally judged as non-natural).

Adult↗
PubMedDate not supplied

[Comparison of wound morphology following gunshots by machine guns and sub-machine guns].

Automatic weapons such as machine guns and submachine guns are found in the German-speaking region only in special army and police units and appear accordingly rarely in homicides, suicides and accidents. In the following, the findings in two cases of death with the use of machine and submachine guns are presented. The first case was a fatal accident during shooting on a training area (current machine gun of the German army, calibre 7.62 x 51 mm), the second case was a killing during a physical conflict (submachine gun MP 40 from World War II, calibre 9 x 19 mm). In the case with the machine gun autopsy disclosed typical entry holes corresponding to the calibre, but unusually large exit wounds with tissue bridges in the wound ground, measuring 4 x 2.5 cm in diameter. By contrast, the second case (submachine gun) showed "normal" entry and exit wounds. The differences are mainly caused by deviating ballistic data of the ammunition used. They are discussed against the background of literature on wound ballistics.

Firearms↗
PubMedDate not supplied

[Fatal child abuse (caused by physical violence) in Germany during 1 January 1985 to 2 October 1990. Results of a multicenter study].

UNLABELLED: No reliable data are available on cases of lethal child abuse (by active force) in the area of Federal Republic of Germany prior to reunification (the former West Germany). In a multicenter study we therefore examined the police and court records for such cases occurring in the period 1 January 1985 to 2 October 1990 in nearly the entire area of Federal Republic of Germany. RESULTS: The study center received information on 58 cases of lethal child abuse. Extrapolated to all institutes of legal medicine, this corresponds to 62 cases in all of West Germany in the period studied. An approximately equal number of unreported cases should be added to this figure. Including unreported cases, at least 20 cases of lethal child abuse occurred per year; thus only one in every two cases ever came to light. Almost two thirds of the victims were younger than one year old. At autopsy 59% exhibited signs of repeated abuse at autopsy. By far the most common cause of death was direct impact from a blunt object, usually to the head. Mostly, the male person to whom the victim relates most closely (father, stepfather, partner of the mother) has killed the child. Twenty-one of the 74 persons charged saw the charges against them dropped or were acquitted due to lack of evidence; 51 received sentences ranging from one year probation to life. In the remaining two cases the outcome of the trial was unknown. Signs of abuse were readily apparent at autopsy in almost all cases. The high number of unreported cases underscores the need to educate medical students and practicing physicians to be on the look-out for signs of abuse and argues for an increase in the rate of autopsy.

Autopsy↗