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Biomedical subjects

B Müller

Publications and source records attributed to B Müller.

At least 523 records · Page 29Linked to original sources
PubMed1978

[Experimental studies on the castration osteoporosis in the rat. II. Behavior of bone minerals].

In Wistar rats the bone mineral content of calcium magnesium, phosphor, sodium and potassium was investigated 10 months after complete ovarectomy. 20 of ovarectomized animals obtained in this time 0,65 mg ethinyloestradiolsulfonate/kg/month orally. The ovarectomy decreased significantly the content of calcium and magnesium of femur, humerus, vertebra thoracis and lumbalis. After therapy with the oestrogen these minerals were increased, but not significantly. These results did not correlate with the degree of histomorphometrically established osteoporosis. Phosphor, sodium and potassium were not changed significantly. The role of oestrogen dosis was discussed.

Animals↗
PubMed1977

[Long-term effect of hormonal contraceptives on the behavior of serum lipids].

In order to check the long-term effects of oral contraceptives used in the GDR on certain serum-lipid-fractions, triglycerides, phospholipids, total and free cholesterol, and beta-lipoproteins were determined in four groups of 15 women each, taking the contraceptive preparations Ovosiston, Nonovlon, Gravistat, and Deposiston. Determinations were carried out before and following 3, 6, 12, and 18 month of drug administration. Statistically significant increases of triglycerides occurred under the combined preparations, of phospholipids under Ovosiston and Deposiston and of the beta-lipoproteins under Ovosiston and Gravistat. Total cholesterol showed a slight decrease under all preparations tested. At present the prognostic significance of these slight alterations of serum-lipid-concentrations cannot be estimated completely.

Adult↗
PubMed1977

[Clinical studies on the effect of long term progestagen administration on the elimination of noramidopyrine methanesulfonate (Analgin)].

Pharmacokinetic investigations with the drug noramidopyrinmethansulfonatnatrium (Analgin) were performed in 8 patients who, for a longer period, had taken the progestagene derivative norethisterone acetate. The half life of elimination as expression of biotransformation is clearly increased after intake of norethisterone acetate. As Analgin undergoes an oxydative mechanism of disintegration, possible explanations for this prolongation of the half life of elimination are discussed in the light of relevant literature.

Adult↗
PubMed1976

Fine structure of the antennal receptors of the bed bug, Cimex lectularius L.

Sensilla on the antenna of the bed bug, Cimex lectularius, were studied with the scanning and transmission electron microscope. Those which display a tubular body in the dendrite ending are presumed to have a mechanoreceptor function (bristles of type A, flat plate of type B). Bristles of type A1 contain additional dendrites which terminate at the tip of the bristle and may be gustatory receptors. Sensilla with pores in the hair wall are supposed to have an offactory, humidity and/or temperature receptor function (pegs and hairs of types C, D, E). Hairs of type E contain receptors for the alarm pheromones of the bed bug. Special attention has been paid to the pore structures and epicuticular layers of these sensilla. Possible differences in stimulus conduction are discussed between (i) sensilla with a simple wall and pores with pore tubules (types D and E) and (ii) the ribbed pegs (type C), which have a complex wall structure and spoke channels. The immersed cones of type F have a peculiar innervation, which has not been described previously. Two dendrites are held closely together by a third flat dendrite which wraps around them in the region of the outer segment. Coupling structures were found between the central dendrites, and between these and the third enveloping dendrite. Possible functions of this unique innervation are discussed. The dendrites innervating type D are grouped in three to eight bundles by multiple sheaths. The term thecogen cell is introduced to denote the innermost of the three sheath cells of a sensillum (the outer being the tormogen and the trichogen cell) which builds the dendrite sheath during ontogeny. Comparative morphometry revealed type-specific differences in the length and diameter of the dendrites. Some axons were found to lack any glial or perineurial sheath. Microorganisms were observed in the antennal tissue of several animals.

Animals↗
PubMed1975

Detection and preparation of immunoglobulin (Ig) mu chain protein in sera of patients with heavy chain diseases (HCD).

The detection of Igmu chain proteins in the serum of a patient with HCD by a combining of starch gel electrophoresis and immunodiffusion is described. Partial isolation of mu chain protein by immunoadsorbtion on polyacrylamide gel has been acchieved. As no contaminations of mu chain protein with IgM protein could be detected a separate measurement of these proteins using immunoadsorbants of suitable exclusion limits seems to be possible.

Electrophoresis, Polyacrylamide Gel↗
PubMed1975

[Effect of pregnancy on the biotransformation of aminophenazone].

During delivery there was found a prolongation of the halflife-time of Aminophenazon in comparison with a group of non-pregnant women. Thinlay-chromatography investigations of the metabolitspektrum show, that the cause of this fact is a changed biotransformation in pregnancy. The placental share in metabolism of Aminophenazon is very small. The influence of gestagens concerning the biotransformation is discussed.

Aminopyrine↗