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Biomedical subjects

B Müller

Publications and source records attributed to B Müller.

At least 487 records · Page 27Linked to original sources
PubMed1983

[Blood level kinetics of sodium noramidopyrine methanesulfonate (Analgin) in late pregnancy].

The pharmacokinetic parameters were investigated after a single application of 1,0 g of Analgin to women in labour in comparison with a nonpregnant control group. During the late stage of pregnancy the distribution volume is only slightly increasing. For Analgin a fundamental influence on the level of serum concentration could not be shown. The biological half-life of Analgin shows remarkable individual differences and does not differ significantly between the two investigated groups. Therefore, during pregnancy a change of the applied dose is not indicated.

Adult↗
PubMed1983

[Effectiveness, tolerance, and residue formation of trichlorbon 6%-"new" in controlling hypodermyiasis in cattle in the Mongolian People's Republic].

Field trials in more than 3,000 head of cattle proved the efficacy and compatibility of the insecticide Trichlorphon 6%-"neu"--manufactured by the chemical works in Bitterfeld, German Democratic Republic, on the basis of domestic active ingredients--to be equal to the insecticides used until now. The inhibition of the activity of cholinesterase was moderate but longer lasting than with other preparations. The advantages of Trichlorphon 6%-"neu" are the substitution of imported substances by domestic products, prolonged efficacy, and--by a new formulation--its application at temperatures below zero.

Animals↗
PubMed1982

Pharmacokinetics during pregnancy and delivery.

The pharmacokinetics of certain drugs were studied in the following patient groups: in women in stage III of pregnancy, in women in labor, and in non-pregnant women as a control group. In late gravidity several parameters of distribution and elimination change. Nevertheless, it is not necessary to modify the usual dose schedule. However, sulfonamides and antibiotics should be administered in the upper range of dosage. In contrast to late pregnancy, we found elimination of drugs to be always retarded during labor. Attention must be paid to accumulation, which may occur.

Female↗
PubMed1982

[Studies on the pharmacokinetics of the compound preparation sulfamerazine/trimethoprim (Berlocombin-200) in pregnancy].

Pharmacokinetics of the sulphamerazine/trimethoprim-combination Berlocombin-200 was calculated by an one-compartment-model following therapeutic administration in pregnant women and compared with a control group. Distribution parameters are significantly changed, but elimination half-lifes of both the sulphonamide and trimethoprim are not influenced by repeated administration during pregnancy. There are no consequences concerning the dosage of Berlocombin in bacterial infections during pregnancy.

Drug Combinations↗
PubMed1982

[Pharmacokinetics of antibiotics and sulfanilamides in pregnancy and labor].

Pharmacokinetic parameters may be influenced by pregnancy and labour. A number of antibiotics and chemotherapeutics were studied by the authors who found reduction of fictitious initial concentration as well as increase of both volume of distribution and total clearance. Elimination half-life was found to be prolonged with significance only in women in labour (ampicillin). Studies into drug concentrations and their metabolites did not provide any evidence to change of biotransformation in gravidity. Doses of antimicrobially acting chemopharmaceuticals in gravidity should be close to upper limits.

Anti-Bacterial Agents↗
PubMed1981

Measurement of cardiac output by the thermodilution method in rats. II. Simultaneous measurement of cardiac output and blood pressure in conscious rats.

A method is described for the simultaneous measurement of cardiac output (CO), using the thermodilution method, and arterial blood pressure in conscious unrestrained rats. For the injection of the indicator solution (ice-cold, 0.9% saline) and for the measurement of systolic and diastolic blood pressure, chronically-implanted polyethylene cathethers were used, while CO was measured transpulmonarily with a commercially available CO computer and an acutely-implanted (via caudal artery) arterial thermistor catheter. The following were observed in 10 rats at rest: a CO of 40.2 +/- 1.9 ml/min/100 g, a mean arterial blood pressure of 106 +/- 5 mmHg, a heart rate of 417 +/- 20 beats/min and a peripheral vascular resistance of 2.68 +/- 0.13 mmHG/(ml/min/100 g). After injection of the beta-adrenergic agonist isoprenaline, there was a rise in CO and heart rate, while peripheral resistance and blood pressure were lowered. Injection of the beta-receptor-blocked propranolol caused decreases in CO and heart rate, while peripheral resistance and blood pressure rose. It is concluded, that the method described here for the simultaneous measurement of CO and arterial blood pressure is suitable for the investigation of drug-induced cardiovascular effects in conscious rats.

Animals↗
PubMed1981

The importance of a blind control in the establishment of assigned values in control sera. The establishment of assigned values in control sera, I.

We describe a study by which the establishment of assigned values of a control serum was simulated. The study covered two controls: The internal known control and a blind control. Seven constituents were analyzed in 10 or 11 laboratories, respectively, yielding a total of 72 sets of analytical values. Each set covered double determinations within approximately 18 series for each sample. The course of a blind control correlates better with the unknown sample for which assigned values are to be determined than does a known control. Out of 72 sets 5 sets were found incorrect. Out of these, 2 sets could be recognized exclusively by means of the blind control, and 2 others primarily by means of the known control; one of these could be detected by means of the double determinations. Consequently, a blind control has a greater control efficiency than double determinations.

Blood Chemical Analysis↗
PubMed1981

[On the kinetics of pethidine in the late state of pregnancy (author's transl)].

The kinetic of pethidine (Dolcontral) during late pregnancy was investigated by means of an open two-compartment-model. The results were compared with a control group of nonpregnant women. Some pharmakokinetic parameters were found changed during gravidity, especially the distribution (V1, Vdss, Cpo, delta'), the elimination half-life and the biological half-life (t 1/2; ke1, t 1/2; beta). There was no significant difference in urin excretion of pethidin and norpethidin between both groups.

Adult↗
PubMed1981

[Studies on the kinetics of methaqualone in the course of labour (author's transl)].

A 0,4 g (1598,06 mumol) dose of methaqualone was administered orally to 19 parturient at the beginning of the first stage of delivery. In comparison with former results, got from a control-group of nonpregnant and pregnant women in the last third of pregnancy, it was found a significantly prolonged biological half-life and a decrease of the fictitious initial concentration.

Administration, Oral↗