Biomedical subjects
B M Smith
Publications and source records attributed to B M Smith.
Controlled interviews using drugs.
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A multidisciplinary computerized approach to the study of adjustment to lower limb amputation.
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Emotional expression, memory and feelings during and after interviews with drugs.
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Stresses of the medical student wife.
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Transcutaneous oxygen measurements predict healing of leg wounds with hyperbaric therapy.
Twenty-six patients with chronic leg wounds had transcutaneous oxygen measurements taken from the peri-wound area and a chest reference site before undergoing hyperbaric oxygen therapy in order to evaluate the utility of transcutaneous oxygen measurements in predicting the response of wounds to hyperbaric therapy. Wound scores and wound areas were determined before treatment and after 10 hyperbaric exposures. Patients whose wounds averaged a 5% or greater reduction in wound score per treatment were designated "responders." Nine patients' wounds exhibited at least a 5% reduction in wound score per treatment. There were no differences observed between responders and the 17 nonresponders in age, duration of the wound, initial wound area, initial wound score, or in wound or reference transcutaneous oxygen measurements. Responders required significantly fewer treatments to achieve wound closure than did nonresponders. Peri-wound transcutaneous oxygen pressure when the patient was exposed to 2.4 atmospheres absolute correlated directly with the improvement in wound score per treatment (r = 0.64, p = 0.03). An inverse correlation was noted between surface peri-wound transcutaneous oxygen pressure and improvement in wound score per treatment (r = -0.74, p = 0.006). Elevated peri-wound transcutaneous oxygen measurements at 2.4 atmospheres absolute and reduced peri-wound oxygen measurements at 1 atmosphere absolute were associated with a more rapid response to hyperbaric oxygen treatments in patients with chronic leg wounds. The use of these measurements should allow this expensive and time-consuming therapy to be limited to those patients most likely to benefit.
Saving a dental residency: a joint commitment.
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The penetration of gentamicin and neomycin into perilymph across the round window membrane.
Many commonly employed otic drops contain aminoglycoside antibiotics that may be toxic to the inner ear. A variety of chemicals such as ionic solutions, certain anesthetics, and epinephrine have been shown to diffuse across the round window membrane into the perilymph. Twelve adult cats were studied in this experiment. The auditory bulla was exposed and solutions containing gentamicin or neomycin concentrations similar to that commonly used in otic drops were applied to the round window niche for 15 minutes and washed with saline solution. The gentamicin and neomycin concentrations in the round window niche wash and the perilymph were then assayed by a radioenzymatic method. Concentrations of both antibiotics were observed in the perilymph. Thus, the round window membrane is a route through which these ototoxins may gain access to the inner ear.
An ambulatory activity monitor with solid state memory.
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Back school programs. The ballet dancer.
This article discusses factors influencing back injury in ballet dancers and describes a back rehabilitation program. This program, which applies principles of motor skill acquisition in a progressive manner, has been modified for the young ballet dancer to incorporate aspects of dance class.
Popliteal aneurysm with spontaneous arteriovenous fistula.
This report documents a rare manifestation of aneurysmal disease of the popliteal artery. We describe a popliteal aneurysm presenting with acute venous hypertension due to a spontaneously occurring arteriovenous fistula. The fistula was defunctionalized by treating the aneurysm with a standard technique of exclusion and bypass with resolution of the symptoms of venous hypertension and maintenance of normal distal perfusion.
The influence of preservation techniques on prostacyclin biosynthesis in venous autografts.
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Aortic and inferior vena cava resection for renal cell carcinoma invading an aberrant renal vein.
Renal cell carcinoma which invades the renal veins is a frequent complicating factor in radical nephrectomy. In a 53-year-old patient with a left renal cell carcinoma, tumor thrombus was present in an aberrant, retroaortic left renal vein, and "en bloc" resection of the overlying aneurysmal aorta with a cuff of inferior vena cava was required. The aorta was reconstructed with a dacron bifurcation graft to the iliac arteries, and the vena cava closed primarily. The patient made an uneventful postoperative recovery. The requirement for extensive aortic and vena cava resection need not compromise attempts to cure locally advanced renal cell carcinoma.
"Telling it like it is".
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