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Biomedical subjects

B M Smith

Publications and source records attributed to B M Smith.

At least 109 records · Page 6Linked to original sources
PubMed1976

Stimulated formation of cyclic AMP in different areas of chick brain.

Marked accumulation of cerebral cyclic AMP was induced in the chick by the i.v. administration of isoprenaline or histamine of by decapitation. These responses were examined in various cerebral regions and compared to the responses produced in vitro when maximal concentrations of isoprenaline, histamine or adenosine were added to appropriate brain slices. Histamine only markedly stimulated cyclic AMP formation in the cerebral hemispheres. Isoprenaline was equally potent in the cerebellum and the cerebral hemispheres though the medulla-diencephalon and optic lobes were less responsive. There was a lack of correlation between the effects of decapitation in vivo and the responses to adenosine in vitro. Similar accumulations of cyclic AMP were produced by decapitation in the cerebral hemispheres and cerebellum though adenosine was much more effective on cerebellar slices in vitro. The topographical distribution of catecholamine and histamine sensitive cyclic AMP forming sites do not correlate with endogenous levels of noradrenaline or histamine in chick brain and possible interpretations are discussed.

Adenosine↗
PubMed1975

Characterisation of the adrenoceptor mediating changes in cyclic adenosine 3'-5' monophosphate in chick cerebral hemispheres.

Noradrenaline, adrenaline, isoprenaline and salbutamol induced marked accumulations of cyclic AMP in incubated slices of chick cerebral hemispheres. Isoprenaline was both more potent and more powerful than adrenaline or noradrenaline and the increase in cyclic AMP elicited by the catecholamines was powerfully antagonized by the beta-adrenoceptor antagonist propranolol but not by the alphapadrenoceptor blocker phentolamine. The order of potency of the catecholamines isoprenaline greater than adrenaline greater than noradrenaline and the ability of the non-catechol salbutamol to stimulate cyclic AMP accumulation in chick cerebral slices suggests that the beta-adrenoceptro may resemble that found in the lung (beta2) rather than that in the heart (beta1). Propranolol proved to be a very potent antagonist of the cyclic AMP response induced by isoprenaline in vivo. Beta-adrenoceptor blockade was still evident 12 hrs after a single injection of the durg although only negligible amounts of 3H-propranolol could be detected in cerebral tissue after 2 hrs.

Albuterol↗
PubMed1975

A sublingual-submandibular calcific mass associated with tumoral calcinosis in a patient with suspected milk-alkali syndrome.

The milk-alkali syndrome is a disorder with diverse clinical and biochemical manifestations. It includes three known clinical syndromes. A case of milk-alkali syndrome with associated tumoral calcinosis is presented. The patient developed an unusual oral mass as part of the disease complex. Treatment consisted of excision of the intraoral mass, diet management, and surgical correction of the associated ulcer disease.

Aged↗
PubMed1975

A new synthetic absorbable suture.

The experimental synthetic absorbable suture XLG is a co-polymer derived from lactic and glycolic acid through lactide and glycolide intermediates. Determinations of the rate of loss of strength in various sites in experiments on dogs show that XLG loses strength slightly more rapidly than does chromic catgut. An exception is sutures suspended in the stomach, where catgut quickly loses strength, whereas XLG maintained strength similar to that at other implantation sites.

Abdominal Muscles↗