Lung biopsies of 16 patients with classic idiopathic fibrosing alveolitis (IFA) and 6 patients with sarcoidosis were studied immunohistochemically. It was found that adenomatous hyperplasia (AH) and fibrosing in IFA are potentiated by high expression of thrombocytic growth factor (TGF) and insulin-like growth factor type 1 (IGF-1). Tumor necrosis factor alpha (TNFa) in IFA is actively produced at early stages of the disease. TNFa is drastically reduced in IFA with atypical AH. High level of TNFa produced by alveolar macrophage, pneumocytes type 2 and by other cells is observed in the lungs in sarcoidosis. The level of transforming growth factor (B1-TGF) is rather low in sarcoidosis this being combined with weak interstitial fibrosis (3.75 against 5.06 in IFA). Sarcoidosis granuloma contains proliferating epithelioid cells (as judged by Ki-67), produces a high amount of FTN (4.66), moderate amount of cell fibronectin (2.7), fibroblast growth factor, beta-TGF and IGF-system (1.7; 1.1; 0.8, respectively). Thus, IFA and sarcoidosis are distinguished not only morphologically but by the cytokine profile as well. This implies different approaches to their diagnosis and treatment.

Adult↗

PubMedDate not supplied

[Combination of pulmonary lymphangioleiomyomatosis with skin leiomyomatosis and uterine leiomyoma].

Clinical observation with morphological verification of the above combination in a 48-year-old patient is presented. Large cysts, dystelectasia, fibrosis and smooth muscle proliferation were found in the lungs. The characteristic feature of smooth muscle cells was their differentiation in the direction of myofibroblasts and expression of antigen interacting with HMB-45 antibodies as well as protein products involved in catecholamine metabolism and estrogen receptors.

Angiolipoma↗

PubMedDate not supplied

[Nature of pseudo-amyloid masses in lymphocytic pneumonitis].

The material of open lung biopsies from a female patient with lymphocytic pneumonitis affecting mainly lower parts of the lungs was studied light- and electron-microscopically, immunohistochemically. Diffuse lymphoplasmacytic infiltration with an admixture of macrophages, single giant multinuclear cells and pseudo-amyloid inclusions were found. Morphogenesis of pseudo-amyloid inclusions is related to processes of pulmonary fibro-atelectasis with subsequent imbibition by immunoglobulins (hyperglobulinemia was found in circulating blood).

Adult↗