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Biomedical subjects

B M Kornev

Publications and source records attributed to B M Kornev.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Idiopathic fibrosing alveolitis and bronchioloalveolar cancer].

A case of bronchiolo-alveolar carcinoma (BAC) developing in the presence of idiopathic fibrosing alveolitis (IFA) in a man of 67 with a long history of pulmonary lesion is described. A honeycomb bung was found at the autopsy. Histologically, multiple foci of BAC of mixed-cell structure and those of mucus-producing cells against the background of fibrosing alveolitis at the stage of honeycomb lung were observed. An increased content of collagen type III, IV and V was found immunohistochemically. The role of sclerotic changes and defected immunological surveillance over the epithelial regeneration in the IFA-affected lung in relevant carcinoma genesis is suggested. The origin of the lung carcinoma in IFA is considered to be the regenerating epithelium of the low respiratory tract.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1991

[Intrathoracic and generalized granulomatosis in chronic diffuse liver diseases caused by the hepatitis B virus].

In 7 patients suffering from chronic diffuse liver diseases, they were combined with intrathoracic (3 patients) and generalized (4 patients) granulomatosis. Acute viral hepatitis or risk factors of infecting hepatitis viruses revealed in the case reports of 5 patients preceded the appearance of the signs of both lung and pulmonary damage. In 2 patients (without any indications in the case report to acute viral hepatitis and risk factors of infecting by hepatitis viruses) both the processes were established at a time. HBV markers were detected in all the 7 patients: in the blood serum in 3 and in the blood serum and liver tissue in 4 patients. Besides, HBsAg was identified in the smears of the lavage fluid sediment in 3 patients examined for that purpose. The role of HBV in both etiology of chronic diffuse liver diseases and granulomatosis is under discussion.

Adult↗
PubMed1991

[Scintigraphy of the thoracic lymph nodes and lungs using Ga-67 citrate in combined examination of patients with sarcoidosis].

Altogether 121 patients with sarcoidosis, stages I and II, were investigated by scintigraphy of the intrathoracic lymph nodes and lungs with 67Ga-citrate, determining angiotensin-converting enzyme activity and using bronchoalveolar lavage. RP accumulation in the lymph nodes was shown to reflect disease activity and was not associated with the spreading and stage of a process in the lymph nodes. A possibility of control of therapeutic efficacy (reduced disease activity, regression of the affected areas, and the appearance of new foci) was shown on the basis of analysis of the results of corticosteroid therapy of 37 sarcoidosis patients.

Adult↗
PubMed1991

[Kidney involvement in sarcoidosis].

Variants of renal damage in sarcoidosis demonstrate the diversity of clinical manifestations common to this systemic disease and serve distinctive reference points in the choice of the treatment policy. A well-defined relationship between hypercalciuria associated with sarcoidosis and risk of calcium nephropathy development is, one the one hand, a reliable criterion for the disease activity and, on the other one, the basis for administration of drug the therapy permitting one to control its level (corticosteroids and drugs of the 4-aminoquinoline series). Other variants of renal damage in sarcoidosis, excluding amyloidosis, form the basis for corticosteroid administration even in cases of the presence of renal failure, demonstrating that so-called "dramatic therapy" produces a remarkable beneficial effect characterized by the disappearance of the signs of renal failure.

Amyloidosis↗
PubMed1989

[Effect of glucocorticosteroid therapy on immunologic indicators in patients with sarcoidosis and idiopathic fibrosing alveolitis].

Immunological findings were recorded in 22 patients with active sarcoidosis and 12 patients with idiopathic fibrosing alveolitis. In addition, the patients' endopulmonary cytograms were considered. Immunological evidence involved the use of bronchoalveolar lavage, bronchoscopy, peripheral blood. Administration of corticosteroid therapy resulted in alveolitis attenuation both in sarcoidosis and fibrosing alveolitis. Common features of immune response of sarcoidosis and idiopathic fibrosing alveolitis patients to glucocorticosteroids whose action proceeds as multicomponent immunomodulating effect implying reconstruction of some links of the immune system while aggravating dysfunction of the others are stated.

Chronic Disease↗
PubMed1988

[Current methods of examination in the diagnosis of sarcoidosis of the heart].

Marked clinical or electrocardiographic changes, suggestive of heart disease, were only detected in 14 (7%) of 190 patients with sarcoidosis. Diffuse myocardial accumulation of 99mTc pyrophosphate (2+ or 3+) was seen in 12 (43%) of 28 patients with active sarcoidosis. Repeated scintigraphy showed normal values in 3 patients after a course of corticosteroid therapy. Echocardiographic signs of heart disease were found in 33 (37%) of 89 patients, including left-ventricular contractility disorders in 21, thinning (5) or thickening (7) of left-ventricular wall and ventricular septum, mitral prolapse in 3 and limited pericardial exudate in 5. Signs of pulmonary heart were detected in 17 patients. Clinical and electrocardiographic symptoms of cardiac sarcoidosis were significantly more frequent in patients with myocardial Tc-pyrophosphate accumulation and echocardiographic changes. It is suggested that myocardial Tc-pyrophosphate scintigraphy and echocardiography may be used for the diagnosis of cardiac sarcoidosis, including its latent forms.

Adult↗
PubMed1988

[Diagnostic and treatment problems in sarcoidosis in the therapist's practice].

Altogether 231 sarcoidosis patients were observed. Chest x-ray showed stage I in 116 patients, stage II in 111 patients. Corticosteroid therapy was provided to stage II patients only, with signs of alveolitis activity, for which assessment lung scintigraphy with 67Ga, investigation of bronchoalveolar rinse and determination of the blood angiotensin converting enzyme should be performed. Various extrapulmonary manifestations like hepatosplenomegaly, skin rash, cardiac arrhythmia and conduction disorder, urinary syndrome, etc., were revealed in 28 patients. The authors discussed variants of a course of lesions of the internal organs in sarcoidosis, difficulties of their diagnosis, and indications for steroid therapy. They also recommend a further study of the extrathoracic manifestations of sarcoidosis which frequently determine prognosis of this disease (first of all, cardiac, renal and nervous system affections), serve indicators of its activity (erythema nodosum, uveitis, parotitis, etc.) and present considerable diagnostic difficulties.

Adrenal Cortex Hormones↗
PubMed1988

[Modern criteria of sarcoidosis activity and approaches to glucocorticoid therapy].

Altogether 190 sarcoidosis patients were investigated including cytology of bronchoalveolar rinses in 31 patients, lung scintigraphy with 67Ga in 48, determination of the blood angiotensin converting enzyme activity in 18, and daily calciuria in 100 patients; 50 patients had erythema nodosum which turned out to be one of the main clinical symptoms of sarcoidosis activity. Corticosteroid therapy in patients with erythema nodosum was performed only in the presence of pulmonary changes and/or changes of the other internal organs. Extrathoracic manifestations (liver, splenic, renal, cardiac, CNS lesions) observed in 34 patients, deteriorated prognosis. Prolonged corticosteroid therapy was necessitated in all the cases; 4 patients were operated upon (splenectomy, nephrectomy, implantation of an artificial pacemaker); 3 patients died suddenly or from uremia. Comparison of the results of instrumental and laboratory methods showed that an increase in the lymphocyte count in bronchoalveolar rinses (by greater than 28%), total T-lymphocytes and T-active cells, 67Ga accumulation in the lungs, raised blood angiotensin converting enzyme activity, and hypercalciuria over 300 mg/day could be used as criteria of alveolitis activity in sarcoidosis. Corticosteroid therapy should be performed in stage II patients with the above symptoms only.

Adult↗
PubMed1986

[Erythema nodosum in the clinical picture of internal diseases].

A study of 64 patients with erythema nodosum (EN), including 53 females, showed sarcoidosis diagnosed in 65% of the cases to be the principal cause of EN. It was followed by drug disease (10%), tuberculosis (3%), pregnancy or labor (5%), tumors (3%) and other underlying diseases (Behcet's diseases, streptococcal infection, histoplasmosis, nonspecific aorto-arteritis, chronic active hepatitis). The cause of EN could not be identified in 5% of patients only. Two or three possible etiologic factors were identified in 17%. Sarcoidosis combined with EN regressed without treatment in 82% of cases. Corticosteroid therapy was only given in cases of pulmonary lesion or other systemic manifestations. Purposeful investigation is believed to be capable of establishing etiology of EN in virtually all cases.

Adolescent↗
PubMed1985

[Clinical characteristics of myxoma of the heart].

The authors describe 3 cases of left atrial myxoma confirmed by two-dimensional echocardiography and at operation. One patient had the symptoms of embolisms to the cerebral and renal vessels in the absence of heart disease, 2 patients presented with the symptoms of congestive heart failure. In one patient, loud first sound as well as systolic and diastolic murmur at the heart apex were documented. The nonspecific manifestations (weight loss, fever, high ESR, dysproteinemia, and rheumatoid factor) were observed in all the cases. The difficulties encountered in the clinical diagnosis of heart myxoma are discussed. The differential diagnosis is made between valvular heart disease and infective endocarditis, systemic vasculitis, cardiomyopathy, etc. Echocardiography to exclude myxoma should be performed in patients with thromboembolism, rheumatic valvular disease, subacute endocarditis (particularly in the absence of the classical symptoms) and in those with fever of unknown origin.

Adult↗
PubMed1985

[Pulmonary granulomatosis in chronic active hepatitis of viral origin (report of a case)].

The authors describe pulmonary granulomatosis in a male patient with chronic active hepatitis of viral etiology with persistence of hepatitis B virus in blood serum and liver tissue. The presence of active virus infection with proven hepatitis B virus replication, evidenced by demonstration of HBeAg and HBcAb in blood serum, suggests an importance of universal etiological factor in the development of liver and lung lesions in the given patient, which is confirmed indirectly by demonstration of HBsAg in the cells of lavage fluid.

Adult↗