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Biomedical subjects

B M Ansell

Publications and source records attributed to B M Ansell.

At least 145 records · Page 8Linked to original sources
PubMed1978

Mixed connective tissue disease in children.

A diagnosis of Mixed Connective Tissue Disease (MCTD) had been made in five juveniles in the past two years. All have antibodies to the ribonucleoprotein (RNP) component of extractable fluorescence pattern. No child has had life-threatening complications, though three have required steroids to control their symptoms. Antibodies to ENA were looked for in the other sub-groups of Juvenile Chronic Arthritis (JCA); only two of 75 patients with chronic iridocyclitis and antinuclear antibodies had weakly positive tests.

Adolescent↗
PubMed1978

A family with primary protrusio acetabuli.

The family of a child who developed symptoms and flexion contractures with protrusio acetabuli rapidly between the age of 8 and 11 was examined. The mother and one sib showed limitation of hip movements, while radiological criteria for protrusio were found in the mother and 4 of the proband's 8 sibs; only one had complained of pain. At the age of 16 the proband underwent bilateral total replacement arthroplasty; histologically the changes were those of fibrocartilaginous replacement and osteophyte formation.

Acetabulum↗
PubMed1978

A comparative study of Butacote and Naprosyn in ankylosing spondylitis.

A double-blind, cross-over comparison of Naprosyn (naproxen) 750 mg daily and Butacote (enteric-coated phenylbutazone) 300 mg daily was carried out in a multi-centre trial. Twenty-five patients, mostly male and under 40 years of age, were entered. After a 2-week period in which any existing anti-inflammatory drugs were tailed off, patients were entered into the trial and treated for 1 month with each drug. Patients were assessed at 4-weekly intervals. Both drugs significantly reduced morning stiffness. Morning pain and discomfort and wall-tragus distance were also significantly reduced by both drugs during the trial. Results of the Schober test showed improvement during both treatment periods. There were no overall statistically significant differences between the effects of the 2 drugs on objective parameters. However, overall subjective assessment of symptoms showed a greater improvement on Butacote. Treatment preferences by physician and subjective assessment by the patient both favoured Butacote but the difference between the 2 drugs was not statistically significant. Side effects were mostly of a minor nature. One patient had to discontinue the trial, due to indigestion while taking Butacote.

Adult↗
PubMed1977

Measurement of pain in juvenile chronic polyarthritis.

Pain can be measured using a visual analogue scale in children with juvenile chronic polyarthritis. In a study of 100 children failures were uncommon after the age of 5. Pain severity was strikingly lower than in a group of adults with rheumatoid arthritis and correlated poorly with other measures of disease severity and activity. Because of the low scores, measurement of pain is likely to be less useful in children for assessing the effects of treatment than it is adults.

Adolescent↗
PubMed1977

Significance of rubella virus infection in juvenile chronic polyarthritis.

Fifty-three patients under the age of 5 years with definite juvenile chronic polyarthritis (JCP) were examined for serological evidence of rubella infection. The prevalence of rubella antibody was found to be low and did not differ significantly from that found in normal children of similar age. Patients with JCP and antibody to rubella virus had a clinical course indistinguishable from those with no detectable rubella antibody.

Antibodies, Viral↗
PubMed1977

The effect of penicillamine on growth as height in juvenile chronic polyarthritis.

When the disease state improves during penicillamine therapy, resumption of growth occurs; if activity persists despite therapy, the expected fall-off in growth due to active Still's disease continues. Penicillamine does not interfere with the growth spurt after withdrawal of corticosteroid therapy or with the maintained slow growth during alternate-day steroid therapy.

Arthritis, Juvenile↗
PubMed1977

Juvenile chronic polyarthritis: clinical sub-groups and response to medication.

Juvenile ankylosing spondylitis, as a clinical entity, is outlined. A double-blind trial compared Safapryn and Butazolidin, each given for 3 months, for 15 treatment periods in 11 patients. No differences were shown, but the study highlighted the problems of assessing this condition, and some comments are made, hopefully, to guide further investigators in this field.

Acetaminophen↗
PubMed1976

Scleroderma in childhood.

Scleroderma in childhood is a rare but confusing disorder. Systemic and diffuse disease do occur but are uncommon. Much more common are local lesions of different types which can be multiple; these are often associated with joint symptoms and the development of joint contractures and tendon contractures due to nodule formation. In such circumstances the condition mimics juvenile chronic polyarthritis (Still's disease). A third, rare variant, sclerodermatous fasciitis, has also been described in one young patient.

Adolescent↗
PubMed1976

HLA frequencies in less common arthropathies.

There was no increased incidence of HLA-B27 in patients suffering from rubella arthropathy, when compared to both the Westminster controls and a group of patients with arthritis secondary to dysentery who nearly all possessed this allele.

Arthritis, Infectious↗