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Biomedical subjects

B M Ansell

Publications and source records attributed to B M Ansell.

At least 127 records · Page 7Linked to original sources
PubMed1981

Aortic regurgitation in seropositive juvenile arthritis.

Seropositive juvenile chronic arthritis is a relatively uncommon form of childhood arthritis, but it often causes severe destruction of joints associated with considerable functional disability. During the last 7 years lone aortic regurgitation has been seen to develop in 4 such patients and pursue a particularly aggressive course. Sudden deterioration occurred in 2, 1 of whom required urgent aortic valve replacement and 1 died while awaiting assessment. Because of this it is important to include regular cardiac appraisal as part of the routine assessment in seropositive juvenile arthritis.

Aortic Valve Insufficiency↗
PubMed1981

Systemic lupus erythematosus in childhood.

The clinical and serological features have been analysed retrospectively in 42 patients with an onset of systemic lupus erythematosus (SLE) up to 16 years of age. Thirty-seven (88.1%) were female and 5 (11.9%) male. The mean age of onset was 12.3 years (range 7-16); 11 patients were 10 years or under. The mean duration of disease from diagnosis was 7.1 years (range 6 months-25 years). There were 6 deaths, 3 from infection, 2 from renal failure, and 1 from heart failure. Survival was calculated both from the date of onset and from the date of diagnosis. With the latter the estimated overall survival at 5 years was 82.6% and at 10 years 76.1%. The survival for patients with lupus nephritis was 59.5% at 5 years and 47.6% at 10 years. These data suggests that SLE in childhood is not necessarily associated with a poor prognosis, though renal involvement is still serious. There appeared to be no major differences between prepubertal, adolescent, and adult SLE with respect to clinical and serological findings.

Adolescent↗
PubMed1981

Uncommon radiological features of chronic arthritis in childhood: a review.

Radiological changes depend on the age of onset as well as the pattern of disease present (Ansell & Kent 1977). Seronegative disease tends to be associated with modelling abnormalities of the epiphyses, loss of joint space and the late development of erosions, although an occasional polyarthritis following systemic disease has a very destructive arthritis and overall failure of growth. Pauciarticular disease is associated with growth anomalies of epiphyses and also metaphyses in asymmetrical fashion. In spondylitic children, enthesiopathies are marked and there is a high incidence of hip involvement. Seropositive juvenile rheumatoid arthritis shows a severe erosive arthropathy early, combined with minor growth changes, particularly bony overgrowth in the hands and feet in the early teens. The hallmark of the psoriatic is the asymmetry and, in a few cases, the destructive nature of asymmetrically involved joints.

Age Factors↗
PubMed1981

Radiological assessment of knees in juvenile chronic arthritis (juvenile rheumatoid arthritis).

Radiological changes in the knees were assessed in those patients with juvenile chronic arthritis who still had evidence of knee involvement 5 years after onset of the disease. The patients were grouped according to age and mode of onset. Osteoporosis, modelling abnormalities, growth arrest lines and joint narrowing were found, but erosive change was less common. Tables are given correlating age of onset of disease with radiologic changes.

Adolescent↗
PubMed1980

Foot function in juvenile chronic arthritis.

Measurement of the force distribution under the foot has been used to assess the effect of juvenile chronic arthritis on foot function. The results obtained from the feet of eight patients were compared with the feet of 11 normal children. The peak forces and contact times were measured for functional areas of the foot. When considered as a group, the patients had significantly reduced loading under all the toes and the two medial metatarsal heads, and increased contact time for the heel.

Adolescent↗
PubMed1980

Knee-joint temperature measurement using a differential thermistor thermometer.

A simple method for measuring joint inflammation with a differential thermistor probe thermometer was applied to acute synovitis of the knee. Temperature assessments were made immediately before and serially after intra-articular steroid therapy. The method was capable of showing a significant difference in temperature between inflamed and normal knees. Knee temperature assessments correlated well with clinical parameters and were essentially independent of room temperature.

Aged↗
PubMed1980

Muscle biopsy in polymyositis and dermatomyositis: a clinicopathological study.

The initial muscle biopsies of 30 patients with active polymyositis or dermatomyositis have been assessed histologically and morphometrically. Only 1 patient (3.3%) had a normal biopsy, while 3 had a normal electromyograph and 8 had a normal serum CPK level. No significant morphological differences were found between the various diagnostic subgroups. Sequential biopsies of 11 of these patients treated either with corticosteroids only or with intensive immunosuppression were studied. With response to treatment atrophy factors, variability coefficients, internal nuclei count, and the various histological changes improved in the whole group of patients. However, there was no consistent correlation between any of the morphological features or between these and clinical parameters in individual patients. The percentage of fibres with internal nuclei in the initial biopsy was lower (P < 0.001) in patients responding to up to 60 mg prednisolone per day than in those who eventually required cytotoxic drugs in addition.

Adolescent↗
PubMed1979

Spinal mobility in the adolescent.

The ranges of spinal movement in 390 healthy children aged from 10 to 15 years have been recorded. These measurements are in two planes, anterior and lateral; they are quick and easy to perform and require no special equipment, just a tape measure. Many conditions occurring in childhood can lead to limitation of spinal movement: these include juvenile ankylosing spondylitis, spondylolisthesis, Scheuermann's vertebral osteochondritis, discitis and vertebral fractures, the latter being not uncommon in children receiving prolonged corticosteroid therapy. The purpose of the present paper is to define the normal range for anterior and lateral spinal flexion in adolescents and to correlate these with sex, age, height and weight.

Adolescent↗
PubMed1979

Rehabilitation in juvenile chronic arthritis.

Rehabilitation or, in the case of young children, habilitation, begins with an appraisal of the type of disease process and therefore its possible outcome and the various problems that are likely to be encountered. This will need to be accompanied by a careful assessment of the whole family background, including the ability and willingness of the parents to carry out what is going to be a long, often difficult and very time-consuming programme. The principles of management are maintenance or improvement in position and function of joints, the learning of new skills consistent with the age of the child and the continuation of education so that the young adult is able to enter the world with as little physical and mental scarring as possible.

Ankle Joint↗
PubMed1979

Antigen-antibody complexes in the serum of patients with juvenile chronic arthritis.

IgG-containing antigen-antibody complexes were detected in the sera of all of 7 patients with the systemic form of juvenile chronic arthritis, usually at high levels. Only 9 of 25 patients with the polyarticular form had such complexes, usually at low levels. Three patients had low levels of serum IgA which were probably drug induced; the one patient with low C2 and the 3 with low yeast opsonisation were probably not more than to be expected in a random population.

Adolescent↗
PubMed1979

Naproxen in juvenile chronic polyarthritis.

Naproxen at 10 mg per kg body weight was compared with aspirin at 80 mg per kg body weight in children suffering from juvenile chronic polyarthritis. It was found to be as effective as aspirin, with certainly no more and possibly fewer gastrointestinal side effects. A long-term tolerance study up to 12 months confirmed that naproxed was a satisfactory nonsteroidal anti-inflammatory drug in the management of various types of juvenile chronic arthritis.

Adolescent↗
PubMed1979

Shoulder problems in juvenile chronic polyarthritis.

A high incidence of shoulder involvement was seen in severely disabled young people suffering from juvenile chronic polyarthritis who were undergoing surgical procedures on the lower limbs. The progressive nature of the radiological changes is described. Possible lines of surgical management are considered.

Adolescent↗