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Biomedical subjects

B Leclercq

Publications and source records attributed to B Leclercq.

At least 127 records · Page 7Linked to original sources
PubMed1975

Studies of the energy and protein requirements of the growing guinea-fowl.

1. Guinea-fowl of both sexes and female chickens were fed from 1 to 12 weeks on diets the energy concentration of which was constant at either 2-6, 2-9 or 3-2 Mcal/kg (10-8, 12-1 or 13-4 MJ/kg) while the calorie to protein ratios were changed, for some groups, from 124 to 157 or 200 at 4 and 8 weeks. 2. Guinea-fowl, but not chickens, were unable to overconsume when the protein concentration was low with the result that the body fat content was not reduced when the protein concentration was increased. 3. In the second trial the ME level of the diets was fixed at 12-6 MJ/kg while the protein content was varied, from 21 to 28% in the diets fed to 6 weeks of age and from 15 to 24% in those fed from 6 to 12 weeks. 4. It is concluded that for the growing guinea-fowl the diet should contain 12-6 MJ ME/kg, the protein concentration reducing from 24 to 26% in the period 0 to 4 weeks to 19 to 20% in the period 4 to 8 weeks and to 16% or less in the period 8 to 12 weeks.

Animal Feed↗
PubMedDate not supplied

Massive blastic infiltration of the liver: a cause of fulminant hepatic failure.

The clinical and pathological findings in four cases of fulminant hepatic failure due to massive infiltration of the liver by acute leukemia or lymphoma are reported. Liver abnormalities were found simultaneously with or led to the discovery of hematologic malignancies, and consisted of marked hepatomegaly and severe hepatocellular insufficiency associated with hyperlactatemia. The blood malignancies were peculiar in their fast cellular growth and large tumor mass. Evolution was rapidly fatal in all these cases. In another patient, marked hepatomegaly and hyperlactatemia revealed the presence of a widespread lymphoma before the appearance of hepatocellular insufficiency. Immediate chemotherapy was instituted, and complete remission without hepatic complication was obtained. It is suggested that malignant hematological diseases with fast cellular growth may present as fulminant hepatic failure. In order to avoid a rapidly fatal outcome secondary to liver failure and metabolic disorders, early recognition of these malignancies is necessary so as to assure prompt administration of appropriate chemotherapy.

Autopsy↗
PubMedDate not supplied

Levels of insulin, corticosterone, T3, T4 and insulin sensitivity in fat and lean chickens.

The late generations of fat (FL) and lean (LL) chickens were compared. In the fasted state, plasma glucose was lower in FL chickens, whereas insulin, T3, T4 and corticosterone were unchanged. In the fed state, plasma insulin and T4 were increased in FL chickens whereas glucose, T3 and corticosterone were unchanged. During ad libitum refeeding both plasma glucose and insulin, and to a lesser degree T3, were lower and T4 higher in FL chickens whereas corticosterone remained unchanged between lines. The low glucose and insulin levels observed in FL during refeeding, which were not observed in the F4 generation, were also found after force-feeding. In contrast, during oral glucose tolerance test, as in previous generations, a better glucose tolerance, higher plasma insulin and slightly higher free fatty acid levels were found in FL chickens. The hypoglycemic effect of exogenous insulin was very similar (and poor) in both lines in the fed state and was higher in FL than in LL chickens in the fasted state. From the present and previous studies, a change in the glucose-insulin balance and possibly, in T3, could account for the differences in fattening of both lines.

Animals↗
PubMedDate not supplied

Glucagon-insulin balance in genetically lean or fat chickens.

Circulating levels of insulin, glucagon, glucose and non-esterified fatty acids (NEFA) were compared in genetically lean (LL) or fat (FL) lines of chickens between 5 and 6 weeks of age. FL birds exhibited lower levels of plasma glucose and higher levels of NEFA when fasted or fed; however no genotypic differences were found for insulin or glucagon. Oral glucose tolerance test induced higher insulin concentrations in FL chickens with faster glucose tolerance whereas glucagon was similar between genotypes. Refeeding led to lower plasma glucose and insulin in FL chickens but similar levels of glucagon in both lines. Exogenous insulin (0.25 or 0.50 U/kg) had less hypoglycemic effects but induced higher levels of glucagon in fasted LL chickens at 0.50 U. The insulin to glucagon ratio cannot explain differences in fattening between genotypes. Lipolysis is slightly higher in FL chickens. A difference between the 2 genotypes for their glucose-insulin balance is probably the main mechanism involved.

Animals↗