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Biomedical subjects

B Law

Publications and source records attributed to B Law.

At least 91 records · Page 5Linked to original sources
PubMed1978

Multidisciplinary training in family planning.

A review of 3 years' experience with multidisciplinary training in Family Planning involving representatives from nursing, medical, social work and education professions is presented. The multidisciplinary principle has been shown to be of value in this field, particularly in respect of improved communication.

Curriculum↗
PubMed1972

Contraception.

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Attitude to Health↗
PubMed1971

Fecundity.

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Contraception↗
PubMed1971

Barrier methods.

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Condoms↗
PubMedDate not supplied

Advantages and disadvantages of low-dose oral contraceptives.

Whenever a medication is prescribed, the lowest effective dose should be selected when possible. This recommendation is particularly important when oral contraception is being considered. In the years since the pill became available, there has been a steady decline in the dosages used. Contemporary "low-dose" varieties are those containing less than 50 micrograms of estrogen. Although they provide equal reliability, low estrogen formulations contain only a fraction of the quantities used in the original varieties. Subjective side effects are reported far less frequently with lower dose pills, and metabolic effects are reduced. The only associated disadvantage is a tendency to more spotting and breakthrough bleeding in early cycles. No matter how low the dose, there will always be some women for whom this method is not suitable. Fortunately, the progestogen-only pill--a consideralby underused contraceptive measure--can often be highly acceptable.

Body Weight↗
PubMedDate not supplied

Fundamental studies in reversed-phase liquid-solid extraction of basic drugs; I: Ionic interactions.

Seven basic solutes with known and controlled pKa (7.93-9.5) and log P (0.23-6.63) values have been used as test probes to study the mechanism involved in liquid-solid extraction with C2 and C18 bonded silica phases. A limited comparison has also been made with underivatized silica and CN phases. In addition to the reversed-phase mechanism, cation-exchange was shown to play a very significant role in the retention process. Various cations both organic and inorganic were assessed for their elution strength, and the ordering was similar to that for classical ion-exchange chromatography. Control of selectivity in the elution process can be achieved by varying the concentration of cation or methanol in the eluent. The C2 cartridge in combination with an aqueous ammonium acetate-methanol eluent proved to be the most versatile in that all compounds, irrespective of pKa or log P could be recovered in high yield. The optimal eluent in terms of selectivity with respect to related compounds could be predicted from the solute log P. Blocking of silanols by pre-conditioning the cartridges with cations prior to sample applications was also studied. The order of cation strengths although somewhat variable was similar to that established at the elution stage. To achieve quantitative elution with methanol or aqueous methanol solutions however, high concentrations of inorganic cations, equivalent to 1 ml of a 1 M solution were required to pre-condition a 100 mg cartridge.

Ion Exchange↗
PubMedDate not supplied

Fundamental studies in reversed-phase liquid-solid extraction of basic drugs; II: Hydrogen bonding effects.

Anomalies in the elution order of the beta-blockers atenolol and propranolol on reversed-phase liquid-solid extraction cartridges have been studied. The hydrogen bond acceptor properties of the polar ring substituent in atenolol was found to result in greater retention than would be expected from the reversed-phase or cation-exchange mechanisms alone. This hydrogen bonding interaction could be attenuated by inclusion of a strong hydrogen bond acceptor in the eluent or more successfully by increasing the eluent water content. The conclusions from this work have been used to explain previously reported anomalies in the solid-phase extraction of polar basic drugs.

Atenolol↗