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Biomedical subjects

B Kaufman

Publications and source records attributed to B Kaufman.

At least 127 records · Page 7Linked to original sources
PubMed1982

Preliminary experimental results in humans and animals with a superconducting, whole-body, nuclear magnetic resonance scanner.

In order to determine the clinical usefulness of nuclear magnetic resonance (NMR) imaging, the investigators examined a variety of normal volunteers, patients with neoplastic lesions, and experimental animals. Preliminary results were obtained with the use of potential contrast agents. It was found that imaging applications of NMR in the vascular system, spine, brain, lung, and mediastinum offer certain advantages over other modalities. The absence of biological hazard as well as the ability to obtain unenhanced, noninvasive, gated images of the vascular system, as demonstrated in this study, make NMR particularly attractive. In addition to single-section capability, NMR makes it possible to obtain volume images of the spine and other organs which can be displayed in any desired plane or section thickness.

Animals↗
PubMed1981

Megalocephaly and hypodense extracerebral fluid collections.

Computed tomographic (CT) scans were identified and reviewed for 25 pediatric patients with enlarged heads and extracerebral fluid collections that showed cerebrospinal fluid-like attenuation. Mild to moderate enlargement of the subarachnoid space over the convexity, interhemispheric fissure, and the lateral ventricles was observed in most of the cases. The CT findings are not specific, and it is not always possible to determine the nature of the extracerebral fluid, whether it lies in the subarachnoid space, the subdural space, or both. The differential diagnosis included subdural effusions, hygromas, preclinical or external hydrocephalus, hypodense subdural hematomas, megalocephaly, and possibly a normal variant. CT remains the method of choice for the initial study of these patients and for subsequent follow-up in selected cases.

Brain Neoplasms↗
PubMed1981

An experimental method for investigating load distribution in the cadaveric human hip.

A method for direct measurement of the local pressures in the acetabular cartilage is described. Pressure transducers were introduced into the subchondral bone and positioned there in contrast with the cartilage: the transducers were calibrated in situ. Twelve cadaveric hips were prepared in this way and the pressures were measured with the joint loaded in flexion, extension, abduction, adduction, and in lateral and medial rotation. The highest pressures were recorded in the anterior and posterior segments of the acetabulum; the lowest pressures were constantly found at the zenith of the joint. The relationship of these findings to the pathogenesis of osteoarthritis is considered.

Acetabulum↗
PubMed1981

Clinical and pathological study of dysplastic gangliocytoma. Case report.

A case of dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease) is reported. Computerized tomography revealed a nonenhancing mass lesion surrounded by areas of calcification. Surgical excision resulted in complete resolution of the patient's symptoms. The histological findings support the concept that this tumor represents a congenital abnormality in granule-cell migration and is not a true neoplasm.

Adult↗
PubMed1980

Angiographic and computed tomographic correlation in cerebral venous angiomas.

Venous angioma of the brain is a rare congenital vascular anomaly. In the last few years there have been several reports on the angiographic appearance of this lesion, but very little has been written about the findings on computed tomography (CT). Angiographically, the arterial phase is normal, while the capillary phase might demonstrate a blush. The major abnormality is the venous phase, where multiple dilated medullary veins converge centrally into a large drainage vein. The two cases presented here correlate the angiographic and CT appearances. It is felt that, with a knowledge of these findings, an accurate diagnosis of this condition can usually be reached.

Adult↗
PubMed1980

Calcification of the choroid plexus visualized by computed tomography.

Physiologic calcification of the choroid plexus increases in frequency and extent with age. As demonstrated in this report, it is visualized nine to 15 times more frequently with computed tomography (CT) than with plain skull radiography. Calcification involving the temporal horns is associated with neurofibromatosis. Young patients with exuberant calcification in the region of the glomerula, or with calcification extending into the bodies of the lateral ventricles should be evaluated for conditions associated with pathological calcification of the choroid plexus. This also applies to patients of any age in whom calcification of the choroid plexus in the roof of the third ventricle or in the region of the foramen of Monro can be visualized with routine CT center and window levels.

Adolescent↗
PubMed1980

Congenital defects of the inner ear in association with meningitis.

Three patients presented with meningitis associated with congenital defects of the inner ear, consisting of a cyst-like cochlea and a short, wide horizontal semicircular canal. The findings were easily identified on routine skull radiographs, alleviating the need for further studies and leading to treatment of the defect.

Adolescent↗
PubMed1980

Cerebral injury in child abuse: a changing profile.

This report of 21 patients with cerebral injury resultant from child abuse, identifies a broad profile of central nervous sequelae from such injuries, 6 patients were admitted with whiplash shaken infants syndrome, all with severe signs of CS dysfunction. 3 children presented with acute cerebral confusions, 2 with severe cord injuries with resultant paresis and 10 with skull fractures or miscellaneous injuries. Computer tomography has proved to be of great assistance in precise identification of site and size of subdural/intracerebral hematomas in abused children and in identifying posterior fossa lesions and providing longitudinal assessment of sequelae of cerebral trauma. Also the role of the Child Protection Team in management of such acutely injured children is defined.

Brain Injuries↗
PubMed1980

Transsphenoidal microsurgery in the treatment of acromegaly and gigantism.

Twenty-five patients with acromegaly and 3 patients with gigantism underwent transsphenoidal microsurgery in an attempt to remove the tumor and preserve normal pituitary function whenever possible. An adenoma was identified and removed in 27 of 28 patients. Evaluation 3--6 months postoperatively revealed a GH level less than 5 ng/ml in 29 patients, 5--10 ng/ml in 4 patients and 11--29 ng/ml in 4 other patients. Dynamics of GH secretion were normal in 11 patients who had normal pituitary function and are considered cured. Two patients with low or undetectable GH levels are also considered cured at the expense of being hypopituitary. Three of 7 patients with normal basal GH levels but abnormal dynamics of GH secretion relapsed within 1 yr. Eleven of the 13 patients considered cured did not have extrasellar extension, while 14 of the 15 patients not cured had extrasellar extension. Five patients who were not cured with surgery received radiation therapy. Three patients were treated with an ergot derivative, Lergotrile mesylate, after surgery and radiation therapy failed to normalize GH levels. Transsphenoidal microsurgery is an optimal form of therapy for patients with acromegaly or gigantism, especially those with no extrasellar extension. Dynamics of GH secretion are very useful in evaluating the completeness of adenoma removal.

Acromegaly↗
PubMed1980

Effect of jogging on serum low density lipoprotein cholesterol.

The effects of jogging on serum lipids were assessed in 16 normolipidemic males who ran an average of 5.8 miles (9.3 kilometres) per week for 6 weeks. There was no change in serum triglyceride concentration or clearance nor in HDL-cholesterol, but both total and LDL-cholesterol concentrations decreased significantly, by 5.7 and 8.3% respectively. Individual decreases in LDL-cholesterol were correlated with the distance run and it seems probable tht a stimulatory effect of exercise on LDL catabolism was responsible. These findings suggest a possible explanation for the known protective effect of exercise against coronary heart disease, even when taken in amounts insufficient to raise HDL-cholesterol.

Adult↗
PubMed1979

Ophthalmoplegia, ataxia and hyporeflexia (Fisher's syndrome). With a midbrain lesion demonstrated by CT scanning.

This report concerns a patient with ophthalmoplegia, ataxia and hyporeflexia (Fisher's syndrome) with a lesion in the midbrain tegmentum demonstrated by computerized-tomography (CT) scanning. Spontaneous recovery was almost complete 1 month after the onset. Based upon its strategic location, it is suggested that the lesion can explain the findings in the patient. The CT finding, if confirmed, will necessitate a reconsideration of our current pathogenetic views about Landry-Guillain-Barré syndrome in general and Fisher's syndrome in particular.

Ataxia↗
PubMed1979

Computerized tomographic diagnosis: pitfalls for neurosurgeons.

Computerized tomography as a diagnostic procedure is characterized by its high sensitivity but limited specificity. This lack of specificity may result in an erroneous diagnosis and, possibly, in ill-advised therapy unless clinical and objective data are carefully considered in interpreting the study. The most common pitfalls encountered are the phenomena of contrast enhancement of infarcts and mass effect associated with infarcts. Many different pathological processes can have similar enhancement patterns. The evolution of high density, acute hemorrhage to isodense areas in the chronic hematoma can become a serious diagnostic problem unless an appropriate history is available. The authors discuss 30 cases in which misinterpretation of CT scans resulted in erroneous diagnoses. Seventeen of these patients underwent operation.

Adult↗
PubMed1979

Acquired middle cranial fossa fistulas: normal pressure and nontraumatic in origin.

To the accepted classification of three types of normal pressure, nontraumatic cerebrospinal fluid (CSF) fistulas, we would add "acquired." This type of CSF fistula tends to occur from the middle cranial fossa because of the enlargement of "pitholes" that are normally present in its anterior medial aspect. The enlargement of these bony defects is due to normal intracranial pressure variations that, not uncommonly, create meningoceles and meningoencephaloceles. A portion of the floor of this area is aerated in up to 10% of the normal population by the lateral recess of the sphenoid sinus, the pterygoid recess. Thus, this area has the potential to act as a pathway between the middle fossa and the paranasal sinuses, allowing cerebrospinal fluid to pass into the sinuses. Isotope and computerized tomographic studies are helpful in the localization of such a CSF leak. Tomography of the base of the skull, however, is essential for the ideal definition of possible routes of fistulization. If there is any question of the presence of a middle fossa fistula, these studies can show whether the floor of this area is pneumatized and whether there are any defects in the floor. The treatment of such a fistula should include generalized reinforcement of the floor of the anterior middle fossa by a middle fossa approach. If any doubt exists as to the site of leakage (anterior or middle fossa), the minimal surgical procedure should include exploration of both areas via a frontotemporal craniotomy.

Cerebrospinal Fluid Rhinorrhea↗