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Biomedical subjects

B K Jain

Publications and source records attributed to B K Jain.

62 records · Page 4Linked to original sources
PubMedDate not supplied

Prevalence of celiac disease among siblings of celiac disease patients.

AIMS: To determine the prevalence of celiac disease (CD) in siblings of patients with this disease in Punjab, where wheat is the staple diet. METHODS: Families of 80 patients with CD diagnosed as per modified ESPGAN criteria were offered family screening. Their siblings aged 2-15 years were tested for serum IgA anti-tissue transglutaminase antibody (anti-tTG) antibody. Those with positive or borderline test and some of those with negative test underwent endoscopic duodenal biopsy. Siblings with characteristics histological findings and showing improvement on follow-up were labeled as having celiac disease. RESULTS: Of the 63 siblings of 48 index cases studied, 15 tested positive for anti-tTG; of these 13 had celiac disease. Three tested borderline for anti-tTG; none of them had CD. Of the 45 anti-tTG-negative subjects, two agreed to undergo biopsy; one of these had features of CD. Overall, 14 of 63 (22%) siblings had CD, including 8 who had no symptoms suggestive of CD. CONCLUSIONS: CD is common among siblings of patients with CD in Punjab and may be asymptomatic.

Adolescent↗
PubMedDate not supplied

Norms and clinical correlates of echocardiographic left ventricular mass in 3-12 year old children.

To determine norms for left ventricular mass (LVM) and correlate it with various demographic and clinical parameters 213 school children were examined using two dimensional echocardiography. The data of 183 children (108 boys, 75 girls) where no cardiovascular abnormality was found has been analysed. The mean age +/- SEM was 6.79 +/- 0.15 years. The mean LVM was 40.47 +/- 1.12 gm (40.05 +/- 1.45 gm in males; 41.06 +/- 1.79 gm in females; p greater than 0.6). Mean LVM index (grams/metre height) was 34.30 +/- 0.80 (male = 33.46 +/- 1.06; female = 35.45 +/- 1.22; p = 0.9). On univariate analysis, a significant positive correlation of LVM with age, (r = 0.57), height (r = 0.57), weight (r = 0.58) and chest size (r = 0.23) was observed. No correlation was seen with resting pulse rate, or with systolic and diastolic blood pressure.

Child↗
PubMedDate not supplied

Influence of alcohol intake on high density lipoprotein cholesterol levels in middle-aged men.

To study the influence of alcohol (ethanol) intake on high density lipoprotein cholesterol (HDLC) levels, we studied 210 healthy middle-aged men (age 45 +/- 8 years). Other factors influencing HDLC (physical exercise, diet, smoking and body mass index) were also studied. Individuals were classified according to daily ethanol consumption. There were 39 teetotallers, 29 took drink, 30 took 1-1.9, 25 took 2-2.9, 26 took 3-3.9, 28 took 4-4.9 and 33 took 5 or more drinks per day (1 drink = 14 gm ethanol). The overall mean serum total cholesterol was 191.4 +/- 53 mg/dl and HDLC was 46.4 +/- 9 mg/dl. Total cholesterol in teetotallers was not different from those consuming different amounts of alcohol. HDLC in teetotallers (44.5 +/- 8 mg/dl) was significantly lower than in those taking 1-1.9 drinks (46.7 +/- 11 mg/dl, p < 0.05) and 2-2.9 drinks/day (51.4 +/- 9 mg/dl, p < 0.01) but was not different from those consuming > or = 3.0 drinks. There was a weak positive linear correlation between ethanol and HDLC (r = 0.016). HDLC levels were significantly lower in smokers (43.5 +/- 9 vs 47.2 +/- 11 mg/dl in non-smokers), in non-vegetarians (43.5 +/- 10 vs 46.2 +/- 9 mg/dl in vegetarians) and in those with sedentary habits (42.4 +/- 7 vs 46.1 +/- 10 mg/dl in physically active). Low level ethanol consumption (< 3 drinks or 42 gm per day) is associated with increased HDLC levels.

Alcohol Drinking↗