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Biomedical subjects

B Johansson

Publications and source records attributed to B Johansson.

At least 703 records · Page 39Linked to original sources
PubMed1981

Longitudinal studies of blood lymphocyte capacity in Hodgkin's disease.

Blood lymphocyte functional capacity and serum immunoglobulins were studied in 40 patients with Hodgkin's disease (HD) admitted to Radiumhemmet, Stockholm, before treatment and in complete remission 2-56 months following termination of radiotherapy (total nodal irradiation [TNI]; n = 29) or chemotherapy (MOPP; n = 11). Lymphocyte studies included determination of total lymphocyte and T-cell counts and evaluation of spontaneous DNA synthesis during the first day of culture and mitogen-(concanavalin A, pokeweed mitogen) and antigen (purified protein derivative, PPD)-induced activation on the third day. Blood lymphocyte and T-cell counts decreased dramatically following TNI. A slow restitution was seen, but pretreatment levels were not reached even four years following therapy. The responses to ConA and PPD but not PWM were significantly reduced shortly after TNI. The mitogen response did not increase with time as did the PPD response. Lymphocyte counts and lymphocyte stimulation, which were severely depressed before treatment of patients in the chemotherapy group, remained unchanged 2-36 months after termination of therapy. A significant reduction of IgM levels was observed regardless of the mode of treatment. Splenectomy prevented the profound reduction of blood lymphocyte and T-cell counts following therapy but did not influence the other immunologic variables under study.

Adolescent↗
PubMed1981

On the size and tumor involvement of the spleen in Hodgkin's disease.

Fifty-four untreated patients with Hodgkin's disease (HD) subjected to splenectomy were studied with respect to preoperatively assessed spleen size compared to postoperative findings. Before splenectomy, nine patients had "normal sized" spleens, 18 patients had spleens weighing greater than or equal to 200 g and 14/39 spleens were tumor-involved. Nine patients had "enlarged" but unpalpable spleens. Eight of these weighed greater than 200 g and 3/9 spleens showed tumor involvement. Six patients with preoperatively palpable spleens showed tumor involvement, their spleens weighed greater than 660 g. The results confirm the inaccuracy of non-invasive procedures in prediction of spleen size and tumor involvement in HD.

Adolescent↗
PubMed1981

Routine laboratory tests in relation to spleen size and tumour involvement in untreated Hodgkin's disease.

A number of routine laboratory tests were studied in 39 untreated patients with Hodgkin's disease with respect to size and tumour involvement of the spleen. Eighteen patients with tumour-engaged spleens had lower total lymphocyte counts and IgG and IgM levels than patients with non-involved spleens. However, no significant differences in these respects were found between patients with tumour-involved spleens weighing less than 500 g and patients without splenic tumour involvement. Hemoglobin values were inversely and reticulocyte counts positively correlated with the weight of involved spleens. Remaining laboratory variables under study, e.g. total granulocyte counts, platelet counts, ESR and liver enzymes, were not associated with the size or tumour involvement of the spleen. It may be concluded that routine laboratory tests yield no specific information as to splenic tumour involvement or size.

Adolescent↗
PubMed1981

Bond strength of porcelain to dental alloys - an evaluation of two test methods.

Two methods for measuring shear strength of the porcelain-metal interface, a rod/disk-push test and a cube/cube-push test, were compared using the same metals and porcelain material. Both types of specimen showed evidence of complex stress distribution at the interface during loading and a fracture line located mainly in the opaque porcelain layer. Both methods were thus mainly a test of the "strength" of the porcelain at the interface. The "bond strength values" obtained with the rod/disk specimen seemed to depend on the geometry of the specimen and the values obtained with the cube/cube specimen seemed to depend on the quality of the porcelain work. It seems questionable whether "bond strength values" as obtained with these two methods can be the basis for requirements in a standard for porcelain-metal systems.

Chemical Phenomena↗
PubMed1981

An EBV-associated, Swedish case of Burkitt-type malignant lymphoma.

Morphological, serological, DNA-homology and immunofluorescence studies of a rapidly fatal malignant lymphoma in a 25-year-old Sweden male revealed most of the characteristics of an EBV-associated Burkitt lymphoma. The various findings are discussed in relation to previously reported observations on endemic (African) and non-endemic Burkitt lymphomas.

Adult↗
PubMed1981

Quantitative aspects of electrical and mechanical responses to anisosmolar solutions in the smooth muscle of the rat portal vein.

The electrical and mechanical activity of the rat portal vein were studied quantitatively under prolonged exposure to solutions in which osmolality was varied by changes in sucrose content. Reducing osmolality by 15 or 30 mosm/kg below the control value of 290 mosm/kg caused enhanced electrical and mechanical activity whereas hyperosmolality up to 390 mosm/kg led to inhibition as demonstrated earlier. These responses faded under prolonged exposure. In hypoosmolality integrated mechanical activity returned to control after about 10-15 min while spike activity remained somewhat increased. Prolonged hyperosmolality was associated with return of spike discharge towards control frequency whereas the integrated contractile force reverted from initial inhibition to levels above control after some 10-15 min. Therefore, the integrated force per spike was increased by prolonged hyperosmolality and decreased by hypoosmolality. Variation in osmolality had similar effects on the amplitude of K+ contractures. The time course of the osmotic responses are discussed in relation to the dynamic effects of passive stretch and shortening in the portal vein. The relation that may exist between "intropic" effects of osmolality and the contractures obtained in strongly hypertonic media is considered.

Animals↗
PubMed1981

Responses to ions and vasoconstrictor agents and changes of potassium fluxes in vascular smooth muscle during hypoxia.

An inhibitory effect of hypoxia (Po2 less than 5 mmHg) on electrical and mechanical activity of the smooth muscle of the rat portal vein has been described by Hellstrand, Johansson & Norberg (1977). The present study using the sucrose gap method confirmed their finding that spontaneous activity was completely (or almost completely) abolished by the low Po2. Increased [K+]0 from 6 to 24 mM or decreased [Na+]0 from 137.5 to 76.5 mM reinitiated electrical and mechanical activity during hypoxia. If muscle activity had already been increased by 24 mM K+ or 76.5 mM Na+ solutions in the aerobic situation, switching to hypoxia caused only partial inhibition. In hypoxic solutions of such altered ionic composition a gradual increase in muscle activity with time was seen especially in the low Na+-solution. Stimulating agents such as noradrenaline, acetylcholine, 4-aminopyridine, and Ba2+ could reinitiate spike activity and contractions under hypoxic conditions. Ouabain stimulated the activity in normoxia but no effect was seen in hypoxia. Uptake and washout of 42K+ was studied. No difference in uptake was found between normoxic and hypoxic conditions. The rate of 42K+ efflux was decreased under hypoxia. A similar decrease was produced by Mn2+ (0.4 mM) which, like hypoxia abolished phasic muscle activity. In both cases the reduction in 42K+ efflux may just reflect the elimination of action potentials. It is concluded from these results that profound hypoxia exerts its inhibitory effect on the smooth muscle to a large extent through membrane mechanisms responsible for pacemaker activity or spike generation. The electrophysiological response may be secondary to change in intracellular [Na+] or [Ca2+].

Animals↗
PubMed1981

Structural and mechanical alterations in hypertrophic venous smooth muscle.

Portal hypertension was induced in rats by partial ligation of the hepatic branches of the portal vein. After 5 days the transluminal pressure of the portal vein was measured, and the vessel was fixed in situ for electron-microscopy, or dissected out and mounted in an apparatus recording force and shortening. Portal veins from sham-operated animals were used as controls. Portal venous pressure had increased about twofold after the partial ligation and the cross-sectional area of the longitudinal muscle layer about twofold. Number of muscle cells per mm2 cross-sectional area decreased to half of the control value, whereas extracellular space in the muscle layer and the dry weight of the preparations were unaltered. Number of cells was unchanged suggesting that no hyperplasia had occurred. Length-passive force relations were shifted towards higher force values in the hypertrophic vessels, whereas passive stress-strain characteristics were similar. The structures that carry passive tension have thus increased in proportion to the vessel as a whole. Length-active tension curves obtained by stimulation with AC current or high K+ solutions indicated that the hypertrophic vessels could not, in relation to optimal length for active force, shorten to the same extent as control vessels. Maximum active tension per vessel was unaltered whereas force per unit muscle area and force per cell had decreased. As the preparations were supramaximally stimulated and had optimal extracellular Ca2+ concentrations we suggest that the amount of functional contractile proteins has not increased in proportion to the increase in size of the muscle cells.

Animals↗
PubMed1981

Peyronie's disease: experience of local treatment with Orgotein.

22 patients with Peyronie's disease have been treated with Orgotein, the new anti-inflammatory metalloprotein which pronounced superoxide dismutase activity patients with long-standing and severe symptoms were selected for the trial. The drug was given monthly by injection into the indurated areas of penis. In 19 patients, where the sexual act could be performed with difficulties or the penile angulation made intercourse impossible, marked improvement was seen or normal function was restored. No adverse reactions by Orgotein were seen.

Adult↗
PubMed1981

Pheochromocytoma of the bladder. A case report.

A 39-year-old male patient with attacks of headache and tachycardia immediately after micturition is described. Systolic blood pressure of 250 mmHg was measured after voiding. Plasma noradrenaline was increased 10 to 20 times above the normal value during the attacks. Cystoscopy, arteriography, catheterization of the caval vein with sampling for plasma catecholamines and computerized tomography all supported the diagnosis of a bladder tumour. A beneficial effect of alpha-receptor blockade preoperatively was demonstrated. The tumour was operatively removed from the bladder. The postoperative course was uneventful.

Adult↗
PubMed1981

Acute gastric erosions in the rat. II. Viability of the gastric mucosa.

The autoradiographic appearance of the gastric mucosa, 5 hours after administration of indomethacin, was investigated in 29 adult rats. Indomethacin induced superficial gastric erosions. Autoradiography demonstrated the presence of viable gastric cells (as deduced by their ability to incorporate 3H-cytidine, an RNA precursor) not only in the mucosa without erosions, but also in the mucosa underneath the superficial erosions. The results indicate that indomethacin induced gastric erosions are not the superficial expression of the necrotic process taking place in the full thickness of the gastric mucosa at a particular site. A lumen-borne mechanism appears to be responsible for the formation of erosive areas in the mucosa.

Animals↗