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Biomedical subjects

B Herbeth

Publications and source records attributed to B Herbeth.

76 records · Page 5Linked to original sources
PubMedDate not supplied

[Glutathione S-transferases genetic polymorphisms and human diseases: overview of epidemiological studies].

Glutathione S-transferases (GST), xenobiotic-metabolising enzymes, are involved in the metabolic detoxification of various environmental carcinogens. Particular genetic polymorphisms of these enzymes have been shown to influence individual susceptibility against various pathologies including cancer, cardiovascular and respiratory diseases. The results from the meta-analysis indicate that GSTM1*0 null allele was associated with enhanced risk for lung (OR (95% IC) = 1,17 (1,07-1,27)), bladder (OR = 1,44 (1,23-1,68) and larynx cancer (OR = 1,42 (1,10-1,84)). GSTT1 null genotype was associated with increased astrocytomas (OR = 2,36 (1,41-3,94)) and meningiomas (OR = 3,57 (1,82-6,92)) cancer risk. GSTP1 allelic polymorphism influence the development of bladder cancer in smokers (OR = 2,40 (1,12-4,95)) and occupational asthma (OR = 3,5 (2,7-4,6)). Finally, GSTM1*0 null allele and GSTT1*1 functional allele were associated with increased risk for coronary heart diseases in smokers (OR = 2,30 (1,40-9,00)) and OR = 2,5 (1,30-4,80), respectively). The GSTT1*1 functional allele was also significantly associated with increased risk of lower extremity arterial disease (OR = 3,60 (1,40-9,00). These epidemiological data suggest that genetic GST polymorphisms influence the individual susceptibility to these diseases. Contrary to cardiovascular disease, no evidence of interaction between GST genotype and smoking status was found in lung cancer but it has not been studied in other cancers. Consequently, other works are necessary to study the potential interaction between GST genotype and environmental carcinogens including tobacco smoke extract.

Cardiovascular Diseases↗
PubMedDate not supplied

[Nutrition of adolescent girls in Lorraine].

A survey concerning the nutritional habits, using the method of the dietary history, was undertaken among 273 girls aged 10 to 16 and examined at the Preventive Medicine Center in Nancy. The energy amount, on average 2,363 calories/day (9.88 MJ) and the distribution among the various nutriments differed little from the French recommendations. Energy intakes varied with bone ages and the socio-cultural level of parents. No intake changes were found with respect to the degree of overweight or to the growth peak. The study of the distribution of intakes according to the main groups of aliments showed the important place of dairy products (14.6%), breads (13.9%) as well as sweets and pastries (11.8%, 12.9%), distribution independent of age. Lunch represents the most important meal of the day (35.7%). Snacks provide as much energy as breakfast. The latter is insufficient in 20% of cases. However, this insufficiency is compensated during the day.

Adolescent↗
PubMedDate not supplied

[Criteria for addition of apolipoprotein B measurement during routine health screening examinations: validation in a Stanislas cohort. The Biologist's Group of the Health Examination Center].

The purpose of this study was to determine the criteria in which apolipoproteins AI and B should be performed during periodic health screening examinations. Clinically, the results of apolipoproteins AI and B are most useful when there are minor lipid perturbations (cholesterol and triglycerides), but their routine determination is not justified. Several mathematical models, defined by discriminate factorial analysis, have been studied. The one based uniquely on cholesterol and triglyceride concentrations was the most efficient in identifying patients in whom apolipoprotein B should be determined. In contrast, no model was found for the indication of apolipoprotein AI determination. Data from a population different from that used for the model establishment were used to validate the model. This strategy, determining criteria for additional measurement of apolipoprotein B in a general population, is of clinical interest because it may provide complementary information for subjects with atherogenic risk. Moreover, it is of economical interest because it has the potential of limiting complementary testing and its associated costs.

Adult↗