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Biomedical subjects

B Herbeth

Publications and source records attributed to B Herbeth.

At least 73 records · Page 4Linked to original sources
PubMed1988

Dietary behavior of French men according to alcohol drinking pattern.

Relationships of alcohol consumption with diet were studied in 216 French men aged 18-44. The sample was divided on the basis of alcohol intake in the preceding 7 days: controls (less than or equal to 43 g/day), moderate drinkers (44-87 g/day) and heavy drinkers (88-200 g/day). Moderate and heavy drinkers consumed more meat and meat products, bread and toast, dried vegetables and potatoes than controls but fewer nonalcoholic drinks and less milk, yogurt, cooked vegetables, raw and cooked fruits, pastries and confectioneries. Total energy intake was higher in drinkers than in controls but nonalcoholic energy intake was not significantly different; alcohol was simply added to food intake. Moderate and heavy drinkers consumed significantly less carbohydrates but more fat and protein than controls. Vitamins A and C intakes were lower in the moderate and heavy drinkers than in controls but folate and iron intakes were higher. The differences in dietary habits between controls and drinkers were not related to age nor to socioprofessional status since after adjustment for these two parameters the same relationships were still found.

Adolescent↗
PubMed1988

Familial resemblance of plasma angiotensin-converting enzyme level: the Nancy Study.

Plasma angiotensin I-converting enzyme (ACE) activity has been measured in a sample of 87 healthy families participating in a study of cardiovascular risk factors. The mean +/- SD levels of plasma ACE were 34.1 +/- 10.7, 30.7 +/- 10.4 and 43.1 +/- 17.2 units/liter in fathers (n = 87), mothers (n = 87) and offspring (n = 169), respectively. Plasma ACE was uncorrelated with age, height, weight, or blood pressure in the parents, but a negative correlation with age was observed in offspring (r = -.32). The age-adjusted familial correlations of plasma ACE were .038, .166, .323 and .303 for spouses, father-offspring, mother-offspring, and siblings, respectively. The results of the genetic analysis suggest that a major gene may affect the interindividual variability of plasma ACE, with different codominant effects in parents and offspring. According to this model, the major gene effect accounts for 4.8, 4.0, and 10.8 units/liter of the overall mean and for 29%, 29% and 75% of the variance of age-adjusted ACE in fathers, mothers, and offspring, respectively. The estimate of the probability of the less frequent allele is .26, and the major gene effect is approximately twice as great in high homozygotes than in heterozygotes and in offspring than in parents. The results of this study demonstrate the occurrence of a familial resemblance of plasma ACE activity in healthy families and suggest that this observation can be explained by the segregation of a major gene.

Alleles↗
PubMed1986

Reference intervals for vitamins B1, B2, E, D, retinol, beta-carotene, and folate in blood: usefulness of dietary selection criteria.

Reference intervals for normal concentrations in blood of vitamins B1, B2, E, D, retinol, beta-carotene, and folic acid were determined from a selected sample of people attending a Health Examination Center or being examined in occupational health services in France. This reference sample consisted of 362 men and women, ages 18 to 44 years, selected according to the main variation factors known for the vitamins studied: consumption of tobacco and alcohol, ponderal index (relating height and weight), use of drugs and oral contraceptives, and past history of surgical or medical treatment. Reference intervals were determined for each sex. Vitamin B1 (erythrocyte transketolase activity), plasma retinol, and folic acid values in whole blood are significantly higher in men than in women (p less than 0.001), but vitamin B2 (activation of erythrocyte glutathione reductase) and plasma beta-carotene values are significantly higher in women (p less than 0.001 and less than 0.01 respectively). Dietary intake of vitamins produced no significant displacement of the reference values. For each vitamin we discuss the other major sources of variation factors and the usual values reported in the literature.

Adolescent↗
PubMed1985

"ESVITAF". Survey on the vitamin status of the French: relationships between nutrient intake and biochemical indicators.

The relationships between dietary data and biochemical nutritional status for vitamins B1, B2, A, E, beta-carotene, folic acid and iron have been studied using data from a survey conducted on 710 adults. Significant correlations were found between riboflavin intake and biochemical values for males only (r = -0.105, p less than or equal to 0.05), between beta-carotene intake and plasma beta-carotene (r = 0.232, for males and r = 0.292 for females, p less than or equal to 0.001), and between iron intake and plasma iron for males only (r = 0.115, p less than or equal to 0.05). Concerning nutrient densities, correlations were significant between dietary riboflavin and biochemical measure (r = 0.163, p less than or equal to 0.01 for males, r = -0.135, p less than or equal to 0.05 for females), between vitamin A intake (expressed in retinol equivalent) and beta-carotene (r = 0.212, p less than or equal to 0.001 for males, r = 0.157, p less than or equal to 0.01 for females) and for males only, between dietary iron and hemoglobin (r = 0.144, p less than or equal to 0.01). The dietary data for each nutrient were examined for their sensitivity, specificity and predictive values in identifying subjects with substandard or overstandard biochemical values. For all nutrients the positive predictive value percentage was always below 25%, the negative predictive value percentage always under 75%.

Adolescent↗
PubMed1983

[Biological variations and reference values of transferrin, immunoglobulin A and orosomucoid].

To explain laboratory test results, it is necessary to know for each parameter the biological variation factors and the reference values. The principal biological variations factors for transferrin, IgA and orosomucoid (age, sex, body weight, exercise, puberty, menstrual cycle, professional class and work conditions) have been studied on a sample of the population who have come to the Center for Preventive Medicine (Vandoeuvre-Lès-Nancy, France) for a health check-up (males and females, 4-60 years). We have assembled bibliographical data concerning the other main variations factors. Our results (variations calculated on the medians) and literature results (variations calculated on the medians or on the means) are presented together. These are respectively: 1. For transferrin: age (new-born/20-30 years: -29 to -71%, 50-60 years/20-30 years: -15%), menstrual cycle (+15%), pregnancy (+37 to +70%), exercise (+9 to +13%), oral contraceptives (+10 to +62%), medications (danazol: +60%, testosterone: -13%, D-penicillamine: -13 to -30%, L-asparaginase: -68%); 2. For IgA: age (new-born/20-30 years: -98 to 100%, 3-5 years/20-30 years: about -50%, 50-60 years/20-30 years: up to +60%), sex (men/women: up to +30%), exercise (+14%), pregnancy (-20%), obesity (+30%), season (winter/summer: +10 to +14%, in Africa humid season/dry season: +20%), oral contraceptives (-11 to -40%), medications (L-asparaginase: +36 to +60%), socio-economical factors (black/white: +20 to +75%); 3. For orosomucoid: age (new-born/20-30 years: -70 to -95%, 60-80 years/20-30 years: up to +50%), sex (men/women: up to +15%), obesity (+26%), menstrual cycle (+14%), pregnancy (-20 to -30%), oral contraceptives (-21 to -36%), medications (L-asparaginase: +17%, anabolic steroids: +68%). We determined the three proteins reference values with a nephelometric method.

Age Factors↗
PubMed1981

Influence of oral contraceptives of differing dosages on alpha-1-antitrypsin, gamma-glutamyltransferase and alkaline phosphatase.

We have studied the effects of oral contraceptives on three glycoproteins, alpha-1-antitrypsin (A1AT), gamma-glutamyltransferase (GGT) and alkaline phosphatase (AP), in terms of age (20--40 years), duration of administration, and levels of estrogens. We have confirmed that oral contraceptives increase the concentration of A1AT and the activity of GGT and decrease the activity of AP, but that the modifications are less pronounced with pills containing low levels of estrogens for GGT and AP. We observed a decrease in A1AT and GGT after 2 and 5 years of treatment, respectively, but an increase in AP. Patient age seemed to have little influence on the change in AP activity and A1AT concentration but GGT activity was higher for the 25--30 year group.

Adult↗
PubMed1981

[Study of factors of biological variations acting on the concentration of the alpha-1-serous antitrypsin in a "common population" (author's transl)].

We established by nephelometry the serous concentration in an antitrypsin alpha-1 from an example of common population of th preventive Medicine Center of VAndoeuvre-lès-Nancy (675 adults men and women). First of all, the technical qualities of the equipment (replication : 0.06) to 1.1 per cent) and the dosage method (replication : 1,6 to 2,9 per cent, reproduction 3,4 to 4,3 per cent) were estimated. We showed that the technique was well connected with the electroimmunodiffusion (r : 0.90), but that was an important dissociation between the concentrations established by the two methods. The analytical variation being known, we approached the study of biological variations. The distribution of antitrypsin alpha-1 values is quite log-normal (median : 1,71 g/l, medium : 1,76 G/l). The main factors of biological variation observed are the sex (increase in 6 to 11 per cent in women), the age (decrease in 10 per cent between 20-30 years old and 40-50 years old women), the tobacco (increase in 9,5 per cent in the men smoking more than 20 cigarettes a day), the drinking of alcohol (decrease in 10 per cent for two sexes), the taking of oral contraceptives (increase in 29 per cent). These factors of biological variation should be taken in account at the time of producing the reference values, in addition of the analytical, pathological and genetic factors.

Adult↗
PubMed1980

Study of an enzyme immunoassay kit for carcinoembryonic antigen.

We evaluated a commercial enzyme immunoassay kit for carcinoembryonic antigen (CEA) based on a non-competitive "sandwich principle" method (Abbott Laboratories). The serum sample is treated with an acid buffer and the supernate is incubated with an anti-CEA coated polystyrene bead. After washing, the bead is incubated with an anti-CEA/peroxidase conjugate. After a second washing, the activity of the enzyme bound to the solid phase is assayed after addition of a chromogenic substrate. This activity is proportional to the concentration of CEA in the serum sample. The characteristics of the assay are: (a) good sensitivity (around 0.25 microgram/L) and (b) satisfactory reproducibility (CV < 11% within assay). There is little cross reactivity between CEA and molecules such as nonspecific cross-reacting antigens that are known for their high potential of cross reactivity. No nonspecific interference was encountered with anti-globulin factors. We compared results with this enzyme immunoassay kit with those by a radioimmunoassay provided by the Commissariat à l'Energie Atomique. The correlation (r) was 0.95 (p < 0.001). The distribution of CEA values obtained for 1020 normal subjects is given. We conclude that the kit provides a simple and reliable procedure.

Carcinoembryonic Antigen↗
PubMed1980

A study of factors influencing plasma CEA levels in an unselected population.

Plasma carcinoembryonic antigen (CEA) levels were measured by an immunoenzymic method (Abbott) in 1020 subjects attending the Preventive Medicine Centre (Vandoeuvre-les-Nancy). The results are assessed in relation to: sex, age, body build, fasting/normal food intake, smoking, alcohol intake, drug medication, and working environment. The mean plasma CEA level is 1.53 ng/ml. 87% of the total group has levels less than 2.5 ng/ml, 11.2% levels between 2.5 ng/ml and 5 ng/ml and 1.8% levels above 5 ng/ml. One person had a level above 10 ng/ml. Men had significantly higher CEA levels than women. Smoking was more frequent in both men and women with CEA levels above 2.5 ng/ml. Only in men were age, alcohol consumption and a poor work environment significantly associated with CEA levels higher than 2.5 ng/ml. Obesity in women was related to higher CEA levels. Food intake and drug medication were without influence on the CEA level.

Adolescent↗
PubMedDate not supplied

Family resemblance in body circumferences and their ratios: the Nancy family study.

The purpose of this study was to investigate the familial resemblance for individual body circumferences (suprailiac, waist, thigh and arm) and for the waist/suprailiac (as surrogate for the waist/hip) and the waist/thigh circumference ratios, in a sample of 216 unselected nuclear families with children aged 10-25 years. Familial correlations were jointly computed, using the maximum-likelihood method. The highest familial resemblance was observed for the waist circumference and for the waist/suprailiac and the waist/thigh circumference ratios. There was no significant difference between father-offspring and mother-offspring correlations when considering individual body circumferences. In contrast, when considering the two ratios there was a stronger mother-child than father-child similarity. Furthermore, there was a higher resemblance of the mother with her daughter than with her son, but no significant sib sex difference in the father-offspring relationship. There was also a heterogeneity of sibling correlations for the two ratios, the like-sex pairs exhibiting higher correlations than the unlike-sex pairs. Lastly, the similarity observed between spouses, of similar magnitude to the father-offspring correlation, suggests the contribution of environmental rather than genetic factors for explaining the familial resemblance of the two ratios. In conclusion, the great family resemblance for the waist/suprailiac and the waist/thigh circumference ratios (correlations ranging from 0.23 to 0.68) appears remarkable, and should be taken in consideration, given the predictive value of these indices for disease in adulthood.

Adolescent↗
PubMedDate not supplied

[Vitamins and aging].

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Age Factors↗