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Biomedical subjects

B Habibi

Publications and source records attributed to B Habibi.

At least 19 recordsLinked to original sources
PubMed1993

Impact of screening donor blood for alanine aminotransferase and antibody to hepatitis B core antigen on the risk of hepatitis C virus transmission.

The transfusion-related risk of transmission of hepatitis C virus (HCV) was evaluated in France for the periods before and after exclusion of donor blood units with the surrogate markers elevated alanine aminotransferase (ALT) levels and antibody to hepatitis B core antigen (anti-HBc). A total of 1,412 blood recipients undergoing surgery were followed up prospectively in the period from 1986 to 1989. The stored serum samples were tested for antibodies to HCV by an enzyme immunoassay (EIA) and the result in reactive sera confirmed by a recombinant immunoblot assay (RIBA). The risk of HCV transmission was estimated by the maximum likelihood method for a subpopulation of 892 recipients divided into three groups. Of 55 (3.9%) EIA positive patients, 56.4% were found to be positive prior to transfusion. HCV seroconversion (positive RIBA) occurred in 22 patients (1.6%). The risk of HCV transmission per 1,000 transfused blood units decreased significantly from 4.11 in Group 1 (receiving non-screened blood) to 3.43 in Group II (receiving ALT screened blood) and to 1.40 in Group III (receiving ALT and anti-HBc screened blood). These results demonstrate that screening of donors for surrogate markers had reduced the risk of HCV transmission before the introduction of a systematic anti-HCV screening policy in France in March 1990.

Adolescent↗
PubMed1993

Quantitation of immunoglobulin classes and subclasses of autoantibodies bound to red cells in patients with and without hemolysis.

The concentration of IgG, IgA, and IgM, as well as IgG subclasses, was measured by an enzyme-linked immunosorbent assay in autoantibodies eluted from red cells (RBCs); the number of molecules of each isotype per RBC was calculated. Three groups were analyzed: Group 1 included 23 patients with autoimmune hemolytic anemia (AIHA) associated with warm autoantibodies of IgG class; Group 2 included 11 patients without anemia but with a positive direct antiglobulin test (DAT); Group 3 included 10 healthy DAT-negative subjects. The mean number of IgG molecules per RBC in Group 1 (920) was about three times that in Group 2 (306) and about 17 times that in Group 3 (54). The range of RBC-bound IgG showed an overlap between the two groups of patients. The mean number of IgM and IgA molecules per RBC was low in the three groups. IgG1 predominated in all groups except in two patients with AIHA, in whom IgG3 made up at least 50 percent of total IgG. The mean number of IgG1, IgG2, and IgG4 molecules per RBC in Group 1 was about three times that in Group 2, whereas the mean number of IgG3 molecules per RBC was 10 times as high (p < 0.001). It follows that IgG3 was more common in patients of Group 1, but it was also detected in patients of Group 2.

Anemia, Hemolytic, Autoimmune↗
PubMed1993

IgA cold agglutinins recognize Pr and Sa antigens expressed on glycophorins.

Three cases of IgA kappa cold agglutinins (CAs) were studied. One had anti-Pr1 specificity, one had anti-Pra, and one had anti-Sa. The CAs recognize O-glycans of glycophorins. The findings supplement previous data on anti-Pr1 specificities of four IgA kappa CAs. Because all IgA kappa CAs described recognize O-glycans of glycophorins, a close association between the CA IgA isotype and specificities for O-glycans becomes apparent. It is unlikely, however, that the striking association reflects interrelations between IgA CA structure and specificity, because anti-Sa specificity and all anti-Pr subspecificities were originally defined with IgM CAs.

Adult↗
PubMed1989

[Transfusion and AIDS].

The possibility of transfusion-induced HIV infection by some blood components and plasma derivatives has been recognized since 1982. The implementation of preventive measures has virtually eradicated the risk of HIV transmission by some blood products and dramatically reduced this risk with other blood products. However, the problem remains unresolved in those parts of the world which have a high prevalence of HIV infection and lack effective blood transfusion systems based on voluntary non-remunerated donors. The extremely low residual risk which in Western countries may still be associated with transmission of labile blood components should neither be denied nor unduly exaggerated. The measures currently in use to try and eradicate this risk consist of improvements in the quality of screening tests and of self-exclusion or questionnaire-based deferral of blood donors who have potentially been exposed to viral contamination. The latter challenge can only be faced through efficient information of prospective donors by physicians, public educators and mass media.

Acquired Immunodeficiency Syndrome↗
PubMed1989

[Performance of Pall filters (RC 100 and PL 100) for the removal of leukocytes from red-cell concentrates and platelets].

20 red cell concentrates (buffy-coat not removed), 5 pools of 5 and 5 pools of 10 standards plateles concentrates, as well as 5 single donor platelet concentrates obtained through Haemonetics V50-1 cytoplasmapheresis procedure, were filtered, within 48 hours after donation, using RC 100 and PL 100 blood filters developed by Pall Company. Using the RC 100 filter on red cell concentrates, the rate of leukocyte removal exceeded 99% of the initial values. The residual leukocyte count per unit was 5.8 +/- 3.4 10(6). Leukocytes in red cell concentrates filtered after a previous one on the same filter numbered 18.6 +/- 8.9 10(6). The rate of platelet removal exceeded 97% of the initial amount. Red cell loss was 6 +/- 9% or 4 +/- 3% of a single or a subsequent unit were filtered respectively. Using the PL 100 filter on platelet concentrates, the rate of leukocyte removal exceeded 88% of the initial values. Residual leukocyte counts were 1.4 +/- 0.4 10(6), 6.2 +/- 3.8 10(6) and 1.4 +/- 0.8 10(6) respectively in 6-unit pools, 10-unit pools and machine prepared platelet concentrates. The average platelet loss was 15%. There was no evidence of alteration in the qualitative parameters of red cells or platelets. The filters were easy to handle and the time needed for the whole filtration process was remarkably short.

Blood Cell Count↗