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B Habanec

Publications and source records attributed to B Habanec.

At least 19 recordsLinked to original sources
PubMed2000

[Plexiform fibrohistiocytic tumor of soft tissues and bone].

Plexiform fibrohistiocytic tumor is a rare lesion which has been reported only in the dermis and subcutis so far. We present two cases in this location and an additional one localized in the proximal epiphysis of the tibia. A case with crural location showed predominance of plexiform tumorous nodes with fibrohistiocytic arrangement. The nodes were composed of spindle-shaped myofibroblasts with admixture of histiocytes and giant multinucleated osteoclast-like cells. In another case the tumor of axillary soft tissues featured mostly plexiform bundles of spindle-shaped myofibroblast-like cells reacting positively with actin and CD 68 antibodies; ultrastructurally, they contained numerous dense lysosomal inclusions with myelin figures. The bone tumor was composed of hyalinized fibroblastic component with disperse fibrohistiocytic nodes. Despite a semimalignant character of the lesion there was no recurrence in our cases during the 2-6 year postoperative period.

Adult↗
PubMed2000

Detection of Epstein-Barr virus in Hodgkin's lymphoma (patients in the Czech Republic).

The frequency of EBV demonstrated in patients with Hodgkin's lymphoma (HL) shows geographical variability. In the present study, we investigated the frequency of EBV in HL patients in the Czech Republic. The presence of EBV was determined by immunohistochemistry (IHC) with anti LMP-1 antibody and by in situ hybridization (ISH) method for EBERs. We studied 142 cases with HL. The age of patients ranged from 4 to 82 years. The male to female ratio was 1.2 (males 55.6%). In the series of 142 patients 47 (33%) positive cases were found. The incidence of EBV-positive results was significantly, higher in males than in females (70.2 vs. 29.7%, p = 0.023). Five patients were found in the age group below 10 years. They were positive with LMP-1 antibody and for EBERs in ISH method. The same results were discovered in two patients above the age of eighty. The most frequent histologic types of HL were nodular sclerosis (64 cases) and mixed cellularity (62 cases), respectively. The former type contained 16 EBV-positive cases (25%) and the latter 24 (38%) positive cases. The lymphocyte depletion type 2 (67%); lymphocyte rich type 5 (38%). EBV-positivity examined by ISH and IHC methods determined not only diagnostic Hodgkin cells and Reed-Sternberg cells but also small lymphocytes. In IHC method were small lymphocytes positive in 11 cases, more sensitive ISH revealed 32 positive cases.

Adolescent↗
PubMed2000

[Latent membrane protein LMP-1 in Hodgkin's lymphoma].

The authors examined using the antibody against latent membrane protein (LMP-1) a group of 169 patients with Hodgkin's lymphoma (age 2 to 82 years). From the total number of 169 patients 48 (28%) patients were positive when tested with this antibody. In the whole group the following histological types were represented most frequently: type II (nodular sclerosis) 83 (49%) patients, and type III (mixed cellularity) 70 (41%) patients. Type I (lymphocytic predominance) was not represented. In type IV (lymphocyte depletion) there were three cases (1.7%). Type V (lymphocyte rich) was represented by 13 patients (7.6%). The frequency of positive cases was in these histological types as follows: type II 14 cases (17% of 83 cases), type III 28 cases (40% of 70 cases), type IV 2 cases (66% of 3 cases). type V 4 cases (30% of 13 cases). Distribution of positive cases by age: in children under 10 years a positive finding was recorded in 80%. In old people above the age of 80 years there was a 100% positivity (only two patients were examined). The smallest number of positive cases was in the third decade (of 26 patients 4% were positive). LMP-1 positivity was most frequent in male patients--in 37 (of 96 examined patients) and in 11 female patients (of 73 examined) The frequency of LMP-1 in Hodgkin's lymphoma is consistent with similar studies in economically developed countries. A markedly higher incidence of positive cases in the lowest and highest age groups and gender differences are striking and so far there is no unequivocal explanation for them.

Adolescent↗
PubMed1999

[Pathology of the pancreas. Analysis of 172 resection specimens].

New sophisticated surgical methods enabled interventions on pancreas which kept remaining without attention of gastrointestinal surgeons for a long time because of previously unsolvable reasons. Pancreatic resection specimens enter now the biopsy diagnostics the correct interpretation of which needs a perfect technology of processing. Biopsy under CT monitoring, fibroscopical techniques combined with contrast investigation, biochemical, cytological and bioptic analyses of samples brought new diagnostic aspects into pancreatic disorders. The authors present a classification analysis based on their group of 172 resection specimens from 165 patients: tumor lesions are represented by 52 specimens, inflammatory lesions by 112 specimens, 8 cases are of another nature or are lacking in a clear diagnostic classification. Bioptic investigation can settle the diagnosis of very rare nosological entities which were distinguished before only in necroptic material (adult nesidioblastosis, Schwachman-Diamond syndrome associated with ductal carcinoma of the head of pancreas, and others).

Biopsy↗
PubMed1998

[Effect of H. pylori eradication regimes on the proliferation index of gastric mucosa].

Eradication regimes with the blocking agent of the proton pump and without it do not influence the activity of cell division after treatment of Helicobacter pylori (H.p.) when using cytoflowmetric evaluation. The non-significant difference in proliferation activity of the gastric mucosa after treatment of H.p. can be also a sign of more rapid repair of the gastric mucosa after elimination of the inflammatory elements.

Cell Division↗
PubMed1998

[Gangliocytic paraganglioma of the duodenum].

Gangliocytic Paraganglioma of the duodenum is rare neuroendocrine tumor. This type of the tumor can cause bleeding into the gastrointestinal tract and epigastric pain in this region. It can be difficult to differentiate this tumor from the primary tumor of the head of the pancreas growing secondary to the duodenum. The authors describe one such misdiagnosed case treated finally successfully by hemipancreatodecodenectomy.

Diagnosis, Differential↗
PubMed1997

[Tests for teaching pathologic anatomy].

A teaching database for pathology was prepared comprising around 1250 questions. Five answers belonged to each question, only one of them being correct. Preparation of questions was partly based on testing sets from Medical School of the University of Loma Linda, Ca., partly on those used in 2nd Department of Pathology, Masaryk University Medical School, Brono. In addition, set of computer programmes for automatic generation, printing and evaluation of tests was prepared. They were verified with Brno students.

Education, Medical, Undergraduate↗
PubMed1993

[Bronchopulmonary dysplasia].

Bronchopulmonary dysplasia is a most frequent contemporary lesion of the lung in early childhood. It is characterized by clinical symptoms (neonatal respiratory distress syndrome) and by X-ray picture reflecting progressive morphological changes in the respiratory tract, i.e. in trachea, bronchi, bronchioles, and pulmonary acini, followed by interstitial pulmonary lesion. As usual, bronchopulmonary dysplasia is forerun by hyaline membranes and may be associated with or followed by interstitial emphysema. Pathogenetic participants are toxicity of highly concentrated and long administered oxygen, artificial mechanical ventilation with an intermittently positive pressure, barotrauma first of immature lung causing emphysema and pneumothorax and pneumomediastinum, lung edema, shortage of A and E vitamins and ceruloplasmin deficiency. Morphological changes in bronchopulmonary dysplasia are alike diffuse alveolar damage in bigger children or adults. Nevertheless, neonatal changes differ from later pulmonary lesion by evolving in an immature tissue and by being complicated with necrotizing "obstructive" bronchiolitis.

Bronchopulmonary Dysplasia↗
PubMed1992

[Histiocytosis X and the orbit in children].

Histiocytosis X, a clinical entity which was not defined and classified exactly so far, is manifested by a varied range of clinical manifestations. In rare instances the affection of the orbit is the only and first symptom of the disease. The authors present an account of three children. In one isolated affection of the orbit with a non-inflammatory swelling of the external portion of the upper eyelid was the first symptom of the disease. In the other two patients with the acute multifocal form of histiocytosis X exophthalmos developed only 3 and 7 months resp. after establishment of the diagnosis. In the discussion of symptoms, the prognosis and treatment the authors are inclined to believe that at present the prognosis of multifocal form of the disease is not always adverse. In the frequently difficult differential diagnosis of orbital lesions histiocytosis X should be considered as one of the possible causes of affections of the orbit in children.

Child, Preschool↗
PubMed1989

[Reaction of the trachea after long-term presence of a tracheostomy cannula in an experiment].

The authors investigated in two groups of animals (rabbits, goats) the influence of the prolonged presence of a cannula in the trachea. The greatest differences were found in all groups of animals in the area of the stoma. In rabbits with the period of cannulation the originally slightly suppurative inflammation of the wall and adventitia changed gradually into a non-suppurative inflammation which reduced and disappeared at the end of the experiment. In the group of goats the proliferative exudative inflammation near the stoma with a predominance of leucocytes persisted, while in a more peripheral direction from the stoma the inflammation became non-suppurative with a predominance of mononuclear cells. The prolonged presence of a plastic cannula without a cuff thus did not induce a situation leading to permanent anatomical stenosis.

Animals↗
PubMed1989

[Peroperative biopsy and cytologic diagnosis of pulmonary lesions].

Smears obtained by thin-needle aspiration and scrapings from 116 patients with pulmonary lesions were evaluated on operation after opening of the thoracic cavity. With regard to the macroscopic character of the process and clinical data it thus proved possible to differentiate 37 benign lesions and 79 malignant tumours which could be identified in the majority. The method proved to be rapid, reliable and economical, if aptly used and when the diagnosis is made by an experienced worker.

Biopsy, Needle↗
PubMed1989

[Congenital neuroblastomas].

A group of 2,576 autopsies of children of the age of 0 to 15 years (made between 1978 and 1987) comprised 14 congenital (neonatal) tumours (among 93 tumorous lesions). Teratomas were the most frequent congenital tumours followed by neuroblastomas (4 and 3 cases). Neuroblastomas grew from cervical and thoracoabdominal sympathicus and from the right adrenal medulla. The most frequent and most extent hematogenic dissemination concerned liver, microscopical examination found dissemination in various organs as well as a lymphatic spread to regional lymph nodes (in 2 cases). One case was characterized by an exclusive continual destructive growth in retroperitoneum and posterior mediastinum with 2 macroscopical secondaries in skeleton. Pathognomic differentiated structures were always found by light microscopy. Differential diagnosis of round cell tumours of infancy was discussed with a concise exposure of symptomatology and autoptic findings of neuroblastomas according to congenital cases from literature.

Adolescent↗