Esterification of cholesterol by rabbit testicular mitochondria.
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Biomedical subjects
Publications and source records attributed to B Gondos.
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Levels of cholesterol and cholesterol esters were established in the testes of maturing New Zealand white rabbits. Free cholesterol levels remained relatively constant throughout pre- and post-pubertal development. The total cholesterol, cholesterol esters and percentage esterified cholesterol values were highest during the prepubertal period and decreased steadily thereafter, reaching their lowest after 90 days of age. Correlations of these findings with hormonal and morphological changes during testicular development are discussed.
The surface epithelium of the fetal ovary undergoes diffuse proliferation during the fourth and fifth months of gestation, after which it reverts to a single layer separated from the developing cortex by a tunica albuginea. The proliferation is associated with marked nuclear irregularity and pleomorphism similar to that seen in surface epithelial neoplasms. The epithelial changes occur during the same time period that interstitial cells with ultrastructural and histochemical properties of steroid-secreting tissue appear in the ovarian stroma. The possible role of steroid hormones in stimulating surface epithelial proliferation is discussed.
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