Biomedical subjects

B Gasser

Publications and source records attributed to B Gasser.

97 records · Page 6Linked to original sources

PubMedDate not supplied

Endovaginal sonographic diagnosis of craniorachischisis at 13 weeks of gestation.

A rare case of craniorachischisis associated with trisomy 18 is described. The diagnosis was made by endovaginal sonography during the first trimester of pregnancy. The case is interesting for two reasons. First, it confirms the importance of carrying out an accurate sonographic examination during the first trimester. Second, it shows us that the postmortem examination should be performed by an experienced anatomist: embryos need to be embedded in paraffin wax for microscopic observation and, at present, little is known about the abnormalities of embryo anatomy.

Adult↗

PubMedDate not supplied

How to deal with a rare entity: the coexistence of a complete mole and a healthy egg in a twin pregnancy?

The association of a normal and a molar egg within a twin pregnancy is extremely rare. The key to diagnosis is the fetal karyotype, thus allowing elimination of its principal differential diagnosis: partial triploid mole. We report a case where the evolution of the pregnancy was complicated by severe toxemia. Interruption of pregnancy was then necessary, even though a conservative attitude had first been considered. Throughout this case, we discuss the means of diagnosis and the clinical handling of this rare entity.

Abortion, Therapeutic↗

PubMedDate not supplied

Sirenomelia and situs inversus: case report and review of the literature.

We report a case of sirenomelia of the symelia dipus type which is associated with complete situs inversus. Sirenomelia is difficult to diagnose prenatally because of a frequently associated oligohydramnios. Symelia dipus type adds to the difficulty of the diagnosis, since the bones of the thighs and legs are fully formed. In fact, a close examination of the cases of sirenomelia previously reported in the literature shows that a prenatal diagnosis was achieved only when the oligohydramnios was no more than moderate and/or the associated malformation was of apus or unipus type. We propose a systematic amnioinfusion when one suspects symelia unipus type. Finally, the pathogenesis of sirenomelia is discussed, as the presence of a complete situs inversus in the case reported here could illuminate the debate concerning the origin of the malformation.

Adult↗

PubMedDate not supplied

Use of three-dimensional ultrasound to establish the prenatal diagnosis of Fryns syndrome.

Three-dimensional (3D) imaging permits surface reconstructions that allow a better view of the appearance of organs. We report a case of a fetus with cystic hygroma diagnosed at 11 weeks of gestation, associated with a diaphragmatic hernia. With the 3D reconstruction, we examined the fetal face much more easily, which presented facial dysmorphology, retrognathia, macrostomia and a broad nasal bridge. The conjunctions of these pathological features and a normal karyotype allowed to establish a prenatal diagnosis of Fryns syndrome, confirmed by autopsy.

Adult↗

PubMedDate not supplied

Antenatal diagnosis of brain damage in the survivor after the second trimester death of a monochorionic monoamniotic co-twin: case report and literature review.

At 28 weeks of amenorrhea, 1 fetus of a monoamniotic twin pregnancy died. Ultrasound and Doppler investigations of the surviving twin were normal. Three weeks later, endovaginal ultrasound and magnetic resonance imaging revealed massive bilateral cerebral ischemic necrosis in the surviving twin. In utero fetal blood sampling carried out before the termination did not reveal either anemia or thrombopenia. Current data suggest that cerebral or renal ischemic complications could set in immediately after the death of the first twin as a result of a period of acute hypotension. At least 2 weeks are necessary for them to be identifiable by ultrasound. It seems that they cannot be prevented by prompt delivery of the second twin.

Abortion, Spontaneous↗

PubMedDate not supplied

[A statistical analysis of the results obtained with anti-PCNA/cyclin monoclonal antibody in pulmonary epidermoid carcinomas].

The reaction of PCNA/cyclin protein with anti-PCNA/cyclin monoclonal antibody was positive for most tumoral cells in all types of lung epidermoid carcinomas. The strongest positive reaction characterized the well differentiated epidermoid carcinomas. A constantly strong positive reaction towards anti-PCNA/cyclin was noticed in all multinucleate giant cells of this type of carcinoma. The reaction is also topographically uniform. This heterogeneity can be explained by the asynchronous rhythm division of malignant cells from the various areas of the tumor, or can be due to some cells of different origin and histomorphology, present within the same tumoral mass. Nuclear PCNA/cyclin immunoreactivity can offer information on the proliferation index, that is indirectly on tumor prognosis. This method supports previous assertions that well differentiated epidermoid carcinomas have the best prognosis, while the undifferentiated forms with giant cells have the poorest prognosis.

Antibodies, Monoclonal↗

PubMedDate not supplied

Ciliated bodies in ovarian cyst aspirates.

Ciliated bodies, or detached ciliary tufts, are ciliated fragments of cytoplasm from columnar epithelial cells. In gynecologic cytology they have been observed in cervicovaginal smears and peritoneal washings and very occasionally in fluids from the pouch of Douglas. They occur frequently in the fluids of ovarian cysts. The authors detected ciliated bodies in 30 of 326 ovarian cyst fluid samples (9.20% of cases) taken from 27 patients aged 14-68 years. Ciliated bodies were found in the fluids from both bilateral cysts in one patient and in slides from both former and recurrent cysts in two. Surgery was performed in 14 of the cases, with histologic examination revealing 5 simple serous cysts, 3 paraovarian cysts, 3 serous papillary cystoadenofibromas, 1 serous cystoadenoma and 2 mature cystic teratomas. In the remaining cases the pertinent clinical data, including ultrasound ecography, revealed benign paraovarian and ovarian cysts. The existence of ciliated bodies in the fluids of ovarian cysts indicated the presence of ciliated columnar epithelial cells on the wall of the cysts, which would exclude cysts of follicular origin.

Adolescent↗