Search PubMed⌕ Search

Biomedical subjects

B Friedman

Publications and source records attributed to B Friedman.

At least 163 records · Page 9Linked to original sources
PubMed1982

Epidemiology of temporal arteritis in Israel.

An effort was made to identify all cases of biopsy-proven temporal arteritis (TA) diagnosed in Israel during 1960-78. A total of 46 Jewish patients was found, none of them under 50 yr of age. The age-standardized annual incidence rate of biopsy-proven TA among Jews in Israel rose from 1.6 in 1960-64 to 8.6 in 1975-78, with an overall incidence of 4.9 new cases diagnosed annually/10(6) population greater than or equal to 50 yr. The male:female ratio was 0.95. The annual incidence was 0.2 cases/10(6) population aged 50 to 59 yr, and 11.6/10(6) population greater than or equal to 70 yr of age. We feel that apparent increase in the incidence of TA is due to increased awareness of the disease rather than to an increase in morbidity.

Age Factors↗
PubMed1981

Establishment of normal synaptic density in deafferented olfactory cortex.

The piriform cortex has been examined in rats following neonatal deafferentation produced by olfactory bulb removal. The denervated molecular layer of the piriform cortex grows to nearly its full adult thickness and the removal olfactory bulb axons are replaced by intracortical axons. The synaptic density of the molecular layer following this rearrangement is the same as that in the normal cortex.

Aging↗
PubMed1981

Field evaluation of the membrane filter-disc immunoimmobilization technique in the detection of salmonellae in egg products.

The membrane filter-disc immunoimmobilization (MFDI) technique was found to more sensitive than the official US Department of Agriculture (USDA) method for the detection of salmonellae in unpasteurized egg whites, unpasteurized whole eggs, pasteurized dried eggs and pasteurized whole egg samples examined at two processing facilities over a period of 18 months. Of 70 samples of unpasteurized egg samples examined, 39 were positive for Salmonella by the official USDA method while 54 were positive by the MFDI method. All positive samples by the MFDI technique were confirmed by subculturing on differential plating media and by performing biochemical and serological tests on the isolates. Of 67 pasteurized liquid whole egg and dried egg white samples examined, all were negative for Salmonella by the USDA method while Salmonella was isolated by the MFDI technique from one sample of pasteurized whole egg product.

Animals↗
PubMed1981

Labeling of preformed liposomes with Ga-67 and Tc-99m by chelation.

We have synthesized a long-chain hydrocarbon covalently coupled to diethylene-triaminepenta-acetic acid (stearylamine-DTPA) and have incorporated this compound in liposomes during their preparation. The lipophilic hydrocarbon chain anchors the molecule in the lipid bilayer, exposing the DTPA groups on the surface for chelation. Ethanolic solutions of the lipids are evaporated to dryness under nitrogen in multidose vials; the lipids are suspended in the vial by adding a small volume of distilled water followed by sonication. The liposomes are then labeled by transcomplexation in the case of Ga-67 and by conventional stannous reduction in the case of Tc-99m, by adding the activities directly to the vial. These liposomes bind 95 +/- 5% of Ga-67 and Tc-99m activity, as determined by paper chromatograph assay, eliminating the need for a purification step. The labeled liposomes release about 5% of their Ga-67 activity, and about 30% of their Tc-99m activity after 2 hr of incubation in 50% human plasma at 37 degrees C. Activity released from liposomes labeled with Ga-67 or Tc-99m oxine is much greater under the same conditions. In normal mice the labeled liposomes show biodistributions that are comparable with that obtained with liposomes labeled by conventional techniques.

Amines↗
PubMed1980

Terminal transferase in acute lymphoblastic leukemia in gibbons.

Terminal deoxynucleotidyl transferase, an enzyme which catalyzes the polymerization of deoxyribonucleoside triphosphates on a 3'-OH end of an initiator molecule in the absence of a template, has been suggested as a biological marker for human acute lymphoblastic leukemia. Examination of a cell line, 6G1, recently established from the peripheral blood of a gibbon ape with acute lymphoblastic leukemia showed the presence of terminal deoxynucleotidyl transferase. This enzyme after purification by successive column chromatography on DEAE-cellulose, phosphocellulose and hydroxyapatite, was found to have biochemical properties similar to those reported for terminal transferase from calf thymus and human leukemic cells. These studies suggest that terminal transferase can be used as a useful biological marker for acute lymphoblastic leukemia in both humans and subhuman primates.

Animals↗
PubMed1979

Characterization of an RNA-directed DNA-polymerase from a cell line derived from a radiation-induced lymphoma in mice.

An RNA-directed DNA polymerase was purified from a cell line derived from a radiation-induced lymphoma in NIH Swiss mice which produced non-infectious type C virus particles. The enzyme was isolated from a high speed particulate fraction which bands at a density of 1.16--1.19 g/ml in a sucrose gradient, and purified by successive chromatography on DEAE-cellulose, phosphocellulose and hydroxyapatite. The purified DNA polymerase has a molecular weight of 68 000, a pH optimum of 7.5, a KCl optimum of 50 mM, and a Mn2+ optimum of 0.25 mM. It prefers (dT)15 . (A)n to (dT)15 . (dA)n as the primer template and transcribes the poly(C) strand of (dG)15 .(C)n and (dG)15 . (OMeC)n. It transcribes heteropolymeric regions of avian myeloblastosis virus 70 S RNA, and is inhibited by antiserum to Rauscher murine leukemia virus DNA polymerase. Comparison of the properties of DNA polymerase purified from radiation-induced lymphoma cells with the DNA polymerase purified from non-defective murine type C RNA tumor viruses shows that the mouse lymphoma enzyme is both biochemically and immunologically related to murine leukemia virus DNA polymerases.

Animals↗
PubMed1979

Family bequests and the derived demand for health inputs.

A family investment model whereby parents allocate resources among their own consumption, health investments and financial bequests to children is specified and used to develop hypotheses which are tested on cross section data. As predicted by the model, the demand for physician visits for young children is found to 1) depend on family income only up to some level ($10,000 in 1969 $ in this case), 2) increase with maternal education, and 3) vary with price measures and family size, There is also evidence that greater health investments in young children pay off in fewer severe illnesses in young adulthood.

Adolescent↗
PubMed1979

Sharing arrangements in the nonprofit hospital industry.

The major task of this paper is to develop hypotheses about voluntary sharing arrangements (SAs) from a plausible economic analysis of the hospital industry. The second task of the paper is to review some emerging evidence about SAs. Our research suggests that some SAs could or actually do reduce hospital costs to the community. However, there are reasons which indicate that cost reduction is neither a necessary nor a sufficient result for the success of many SAs.

Cost-Benefit Analysis↗
PubMed1978

The entrapped intestinal balloon: deflation by hyperbaric therapy.

The problem of an entrapped, distended intestinal tube balloon has been successfully resolved on four occasions by hyperbaric therapy. At four to five atmospheres absolute, the volume and diameter of the balloon in all four cases was reduced sufficiently to allow easy and safe extubation. The alternative approaches of forceful, traumatic extubation or laparotomy and enterotomy with their inherent dangers and problems were thus avoided.

Adult↗
PubMed1978

On the rationing of health services and resource availability.

Government controls on availability of physicians and hospital resources can counteract some undesired aggregate consequences of reimbursement insurance. Given aggregate controls, many important questions arise concerning nonprice rationing of services by physicians. A theoretical model of rationing should be consistent with existing items of evidence on delays, disequilibrium, and "availability effects." The model discussed in this paper has a foundation in the mutual advantages of a long-term association between an individual client and physician; these advantages motivate an implicit contract for rationing with a variety of testable implications.

Economics, Medical↗