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Biomedical subjects

B Friedman

Publications and source records attributed to B Friedman.

At least 181 records · Page 10Linked to original sources
PubMed1977

Purification and characterization of baboon endogenous virus DNA polymerase.

An RNA-directed DNA polymerase was purified from baboon endogenous type-C virus by successive column chromatography on DEAE cellulose, phosphocellulose and hydroxyapatite. The purified DNA polymerase has a molecular weight of 68 000, a pH optimum of 8.0, a Mn2+ optimum of 1 mM, and a KCl optimum of 40 mM. The purified enzyme transcribes heteropolymeric regions of viral 60--70 S RNA isolated from different type-C viruses. The purified enzyme is immunologically related to a similarly purified polymerase from the cat endogenous type-C virus RD114.

Animals↗
PubMed1975

Reversibility of joint changes produced by immobilization in rabbits.

Rabbits knee joints which had been immobilized for only 2 weeks regained motion during the first 2 months of remobilization. Histologically, joint tissues were normal. Only 9 of the 14 rabbits immobilized for 6 weeks regained normal or partial knee motion. Animals that regained knee motion generally did so during the first 4 months of remobilization. There are 2 types of repair of the damaged cartilage; replacement by fibrocartilage and proliferation of chondrocytes. Normal chondrocyte alignment and normal collagen fibril orientation was not restored. Repaired cartilage did not withstand normal joint stress.

Animals↗
PubMed1975

The effect of sensory denervation on rabbits' knee joints. A light and electron microscopic study.

Unilateral sensory denervation of the hind limb in a group of rabbits caused progressive atrophy of cells in all structures of the knee joint, whether or not the joint was protected by a plaster cast. Immobilization without denervation caused proliferative changes, first in the synovium and then in the articular cartilage. The initial changes in the articular cartilage following sensory denervation occurred in the middle layers, suggesting that nutritional deficiency was involved. In contrast, the first changes in the cartilage of intact immobilized limbs occurred in the superficial layers and were most likely of mechanical origin.

Animals↗