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Biomedical subjects

B Fraysse

Publications and source records attributed to B Fraysse.

83 records · Page 5Linked to original sources
PubMed1979

Revision of the endolymphatic subarachnoid shunt for Meniere's disease. Review of 59 cases.

Members of the Otologic Medical Group, Inc, Los Angeles, diagnose Meniere's disease in patients with fluctuating hearing loss, fluctuating tinnitus, episodic vertigo, and fluctuating pressure symptoms in the ear. Treatment is vasodilation. If medical treatment fails, an endolymphatic subarachnoid shunt operation is performed. If the shunt relieves symptoms for three or more months but symptoms then recur, revision of the shunt is recommended. If the revision surgery also fails, a destructive procedure is suggested.

Audiometry↗
PubMed1978

Further observations on the vestibulo-dural channel.

A channel between the vestibular aqueduct and the dura, corresponding in texture to the main aqueduct, has been observed in an un-negligible number of cases. All attempts to establish a connection between this phenomenon and a variety of clinical entities, among them Menière's disease, have so far been unsuccessful.

Aged↗
PubMedDate not supplied

Cooperative interaction between Ca2+ binding sites in the hydrophilic loop of the Na(+)-Ca2+ exchanger.

A high affinity Ca(2+)-binding domain which is located in a middle portion of the large intracellular loop of the Na(+)-Ca2+ exchanger contains two highly acidic sequences, each characterized by three consecutive aspartic acid residues (Levitsky DO, Nicoll DA, and Philipson KD (1994) J Biol Chem 269: 22847-22852). This portion of the protein provides secondary Ca2+ regulation of the exchanger activity. To determine number of Ca2+ binding sites participating in formation of the high affinity domain, we isolated polypeptides of different lengths encompassing the domain and measured 45Ca2+ binding. The fusion proteins containing the high affinity domain were obtained in a Ca(2+)-bound form and as evidenced by shifts in there mobility in SDS-polyacrylamide gels after EGTA treatment. The Ca2+ binding curves obtained after equilibrium dialysis reached saturation at 1 microM free Ca2+, Kd value being approx. 0.4 microM. The Ca2+ binding occurred in a highly cooperative manner. Upon saturation, the amount of Ca2+ ion bound varied from 1.3-2.1 mol per mol protein. Proteins with an aspartate in each acidic sequence mutated lacked the positive cooperativity, had lower Ca2+ affinity and bound two to three times less Ca2+. Na(+)-Ca2+ exchangers of tissues other than heart though different from the cardiac exchanger by molecular weight most likely possess a similar Ca2+ binding site. It is concluded that, by analogy with Ca2+ binding proteins of EF-type, the high Ca(2+)-affinity domain of the Na(+)-Ca2+ exchanger is comprised of at least two binding sites interacting cooperatively.

Amino Acid Sequence↗
PubMedDate not supplied

[Acoustic emissions from the ear].

In this paper we study the phenomenon of the acoustic emissions. This study presents two cases with different auditif pathology and their clinics applications.

Acoustic Impedance Tests↗