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Biomedical subjects

B Fleming

Publications and source records attributed to B Fleming.

At least 19 recordsLinked to original sources
PubMed1992

Effect of tension and placement of a prosthetic anterior cruciate ligament on the anteroposterior laxity of the knee.

We wished to determine the optimal tension required to restore normal joint laxity to anterior cruciate ligament (ACL)-deficient knees using a braided polyethylene ACL prosthesis (PACL). In 10 cadaveric specimens, we measured the anteroposterior (AP) laxity of the intact knee at 10 degrees, 30 degrees, 60 degrees, and 90 degrees of flexion. The ACL was then removed and replaced with the PACL using tunnel-tunnel (T-T) and "over-the-top" (OTT) placement techniques. In both positions, the PACL was initially tensioned to 0, 9, 18, and 27 N with the knee flexed to 30 degrees. AP joint laxity was then measured at each flexion angle. With an increase in initial tension, there was a corresponding decrease in AP laxity. At 30 degrees and 90 degrees of flexion, AP laxity was not significantly different from normal using T-T placement and an initial tension of 0 N. At 90 degrees of flexion, AP laxity was not significantly different from normal using OTT placement at 0 or 9 N of initial tension. For both positions, all other tension levels and flexion angles constrained AP laxity. No laxity differences were detected between the OTT and T-T positions at any flexion angle. The variability in AP laxity of the T-T position was significantly greater than OTT. With a 150-N anterior shear force applied to the proximal tibia, the maximum tensions developed in the PACL were not significantly different between the two positions except at 90 degrees. The results suggest that implantation of the PACL is best performed using OTT positioning with an initial tension of 0 N applied at 30 degrees of knee flexion.

Adult↗
PubMed1992

External fixator pin design.

The integrity of the bone-pin interface is the critical link in the stability of external fixation systems. External fixation pins placed in cancellous metaphyseal bone frequently loosen over time, resulting in fixation failure and an increased risk of infection. To design an external fixation pin with optimal bone-metal interface strength in cancellous bone, a systematic study of various thread design features was performed. Combinations of pitch, tooth profile, and minor diameter in 5 mm self-tapping half pins were evaluated in coaxial pullout testing using a fresh bovine cancellous bone. A significant increase in pullout strength was found with a decrease in minor diameter. No statistical differences were found in pullout strength attributable to thread profile and pitch. There were no significant interactions between minor diameter and tooth profile or minor diameter and pitch. The data obtained suggest significantly greater holding power in cancellous bone can be achieved by using an external fixation pin with a smaller minor diameter or a larger interference. Additional pullout testing of five commercially available external fixator pins was performed. Of these, the two pins with the largest interference demonstrated greater pullout strength. Therefore, within a range of acceptable major diameters and adequate minor diameters for the torsional strength requirements, an optimal interference for cancellous pin application may exist and it may well be larger than that present in currently available external fixation pins.

Animals↗
PubMed1990

Antagonists of bombesin/gastrin releasing peptide based on [D-Ala24]GRP(20-26)-heptapeptide. Modifications leading to potent analogues with prolonged duration of action.

Analogues of gastrin releasing peptide (GRP) and bombesin based on His-Trp-Ala-Val-D-Ala-His-Leu, the 20-26 heptapeptide sequence of [D-Ala24]GRP, have been synthesized and tested in vitro for their ability to inhibit GRP (18-27)-induced mitogenesis in Swiss 3T3 cells. Compounds identified as potent antagonists in this test system were also tested in vivo for their ability to inhibit bombesin-induced amylase secretion in rats. The Trp-Ala-Val sequence was found to be a very important feature of the antagonist activity; most substitutions in this region led either to much less potent or inactive analogues. In contrast, amino acid replacements in other parts of the molecule were more tolerated and sometimes led to marked increases in the in vitro and in vivo activity. The most potent analogues were obtained by replacing Leu26 by MeLeu and His25 by Lys(X) where X = Z, PhCO, PhCH2CO or Ph(CH2)2CO. Thus 4-pyridylcarbonyl-His-Trp-Ala-Val-D-Ala-Lys(CO-CH2-CH2-Ph)-Leu- NHMe (86) and 4-pyridylcarbonyl-His-Trp-Ala-Val-D-Ala-Lys(Z)-MeLeu-OMe (87) had IC50 values of less than 20 micrograms/kg s.c. in vivo, and their effects lasted for more than 3 hr.

Amino Acid Sequence↗
PubMed1990

Mechanical evaluation of external fixators used in limb lengthening.

Four external fixator systems (five configurations) used for limb lengthening were tested to determine the fixator stiffness and the fracture gap rigidity. There was a statistical difference between fixators in all modes of loading with respect to stiffness, shear, and axial motion. The fixators were graded to determine their relative stiffness, shear rigidity, and axial rigidity. The EBI Orthofix proved to be the most rigid fixator relative to the configurations tested with minimal shear or axial motion at the fracture site. The Ilizarov tibial configuration was the least rigid, demonstrating more shear and axial motion at the fracture gap. The Ilizarov femoral system combined excellent stability and shear resistance with preservation of axial dynamization. Fixators with a high stiffness provide less motion at the fracture site, which may cause stress shielding of the osteotomy. Fixators that provide more motion at the fracture gap are less stable. These data may be useful in determining which fixator may be ideal for a particular clinical situation.

Biomechanical Phenomena↗
PubMed1989

A biomechanical analysis of the Ilizarov external fixator.

Five configurations of the Ilizarov fixator were analyzed in vitro. The overall stiffness, shear stiffness, and axial motion of the fracture site were determined. The data were compared with the results of eight conventional one-half frame fixators previously tested in the same manner. The Ilizarov fixator allowed significantly more axial motion at the fracture site during axial compression than the other fixators tested. The overall stiffness and shear rigidity of the Ilizarov external fixator were similar to those of the one-half pin fixators in bending and torsion. The stability of the Ilizarov fixator was a function of bone position within the fixator rings and fixation wire tension. The use of olive stop wires increased the shear resistance of the Ilizarov system.

Biomechanical Phenomena↗
PubMed1988

Total knee arthroplasty kinematics. An in vivo evaluation of four different designs.

Thirty-four patients who had 42 total knee arthroplasties during the past 5 years were examined. Four types of total knee arthroplasties (Tricon-M, PCA, Variable Axis, and Anametric) were evaluated, using a computerized knee evaluation system. The patients and 10 controls with normal knees were tested for anteroposterior stability with the Lachman test, medial/lateral stability at 20 degrees, varus/valgus stability at 20 degrees, internal/external rotation at 80 degrees and 20 degrees of flexion, and internal/lateral rotation (screw home) over the active range of motion. At 30 degrees of flexion, the Variable Axis prosthesis was 54% more constrained than the normal knee to anterior/posterior shear. The Anametric and the Variable Axis were more lax under varus/valgus stress than the normal knee by 85% and 71%, respectively. There were no statistical differences for any of the other tests.

Aged↗
PubMed1987

Factors associated with compliance in the follow-up treatment of alcoholism.

This study examined factors associated with compliance in the follow-up treatment of alcoholism. Twenty-five patients who dropped out of treatment within six months were compared with 25 patients who completed a two-year treatment programme. The two groups were compared for socio-demographic factors and personality traits using the EPI and Cattell 16PF. Personality traits did not discriminate between the two groups. However, as in previous studies significant correlation between low socio-economic class and dropping out of treatment was found. Marital instability and a family history of alcoholism also tended to correspond with dropping out of treatment although the tendency was not statistically significant.

Adult↗
PubMed1977

Effects of degree of obesity, age of onset, and weight loss on responsiveness to sensory and external stimuli.

Four experiments tested responsiveness to external and sensory stimuli in female human subjects who differed in degree of overweight and in age of onset of their obesity. The effects of weight loss upon external responsiveness were assessed by testing subjects before and after weight reduction in order to determine the role of energy deficit and deprivation in mediating heightened responsiveness to external cues. There was no significant positive correlation between degree of overweight and degree of external responsiveness. In general, the age of onset of the obesity was also not a relevant factor in the degree of externality. Weight loss did not change responses to visual and cognitive cue salience manipulations in measures of feeding, emotionality, time perception, and short-term recall, whereas responsiveness to variations in palatability increased following weight reduction. While external cue responsiveness does not appear to result from adiposity per se or from deprivation, responsiveness to taste stimuli may reflect these parameters. The role of external and sensory cues in the development and maintenance of obesity is discussed.

Adolescent↗