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Biomedical subjects

B Fekete

Publications and source records attributed to B Fekete.

At least 73 records · Page 4Linked to original sources
PubMed1977

Antibody-dependent cellular cytotoxic activity in patients with Hodgkin disease.

Antibody-dependent cellular cytotoxic activity (ADCC) of twenty-one previously treated patients (stage I--IV) with Hodgkin disease (HD) and eleven healthy controls was studied using specific antibody coated chicken erythrocyte target cells. Cytotoxicity was found to be normal in seven, slightly increased in ten, and considerably increased in four patients. No correlation with the absolute number of lymphocytes, the percentage of spontaneous rosette-forming cells and immunoglobulin bearing lymphocytes was noted. Nor did ADCC correlate with age and clinical or histological classification.

Adolescent↗
PubMed1977

Effect of combined immunosuppressive-cytostatic treatment on antibody-dependent cellular cytotoxicity of patients with chronic glomerulonephritis.

Antibody-dependent cellular cytotoxicity by peripheral blood mononuclear cells was evaluated in 25 patients with chronic glomerulonephritis before and after combined vinblastine-cyclophosphamide-6-mercaptopurine-prednisolone therapy. Purified peripheral blood mononuclear cells of the patients mediated normal killed activity before the treatment and a strong suppression of their cytotoxic capacity was observed after the therapy. The possible significance of the inhibitory effect of immunosuppressive cytostatic treatment on human antibody-dependent cellular cytotoxicity is discussed.

Adolescent↗
PubMed1977

Antibody-dependent cellular cytotoxicity in systemic lupus erythematosus.

Antibody-dependent cellular cytotoxicity of peripheral blood mononuclear cells from fourty-six patients with systemic lupus erythematosus was found to be reduced in two independent test systems. The percentage decrease in cytotoxicity was similar in the tests with allogeneic and xenogeneic targets and it was related to the activity of systemic lupus erythematosus.

Adult↗
PubMed1976

Immune reactivity in subjects remaining tuberculin-negative after repeated BCG vaccination.

Thirty-four children of 12 years mean age having had 3 to 5 BCG vaccinations owing to tuberculin negativity, were subjected to cellular and humoral immune assays (tuberculin skin test, leucocyte migration test, lymphocyte transformation test, estimation of serum IgG, IgA, and IgM levels). It was found that nonreactivity may cease by the age of 11 to 12 years. At the time of study 21 of the 34 children were already tuberculin-positive and only 13 failed to react to 5 TU. The studies confirmed the presence of combined immune deficiencies (negative tuberculin test, negative leucocyte migration test, abnormal immunoglobulin levels) as well as of changes confined to the individual immunoglobulin classes. In the case-history recurrent febrile diseases were found to occur more frequently between the 1st and 6th year of life than between 6 and 12 years of age. It is suggested that nonreactivity to tuberculin results from a congenital partial cellular immune deficiency.

Adolescent↗
PubMed1976

Cellular immune reactivity to nuclear antigens in systemic lupus erythematosus.

The leucocyte migration test (LMT) was used for the study of cellular responsiveness to nuclear factors, i. e. to calf thymus desoxyribonucleic acid (DNA), calf thymus desoxyribonucleoprotein (DNP), calf liver ribonucleic acid (RNA), in 20 subjects with SLE and in 20 non-immunopathological cases serving as controls. The nucleic acid preparations were found to produce a positive LMT in the SLE-patients as well as in the controls. The proportion of positive responses reached its highest percentage in the cases of active SLE. Two cases were followed up by repeated LMT in the course of immunosuppressive treatment with cytostatics and/or antilymphocyte globulin (ALG) administration indicated by the activity of the process. The LMT proved suitable for assessing the intensity of immunosuppression by cytostatics or by ALG. A critical evaluation of the procedure is given. It is pointed out that inhibition and stimulation of migration are likewise manifestations of cellular immune responsiveness. Both inhibition and stimulation are more marked if serum-free nutrient is used.

Adult↗
PubMed1976

Interferon production by human leukaemic leucocytes.

The Sendai virus-induced interferon (IF) production by partially purified human leucocyte suspensions of normal donors and of leukaemic patients have been investigated in vitro. (i) An increased production was observed with leucocytes taken from patients suffering from chronic myelogenous leukaemia (CML) during exacerbation, but the production was approximately normal with cells taken during remission. (ii) IF production was not influenced by large doses of cytostatics (DBM, 5-FU, FUDR, 5-HU, 6-MP, cyclophosphamide) irrespective of whether normal or CML leucocytes were used. (iii) In contrast, production was inhibited in both systems by inhibitors of RNA or protein synthesis (actinomycin D, puromycin, cycloheximide). (iv) CML leucocytes produced IF for a prolonged period of time as compared to normal leucocytes. (v) Leucocytes from children with acute blastic leukaemia and those from adults with chronic lymphoid or acute paramyeloblastic leukaemia produce, in contrast to normal leukocytes, approximately as much IF in the absence as in the presence of serum. It is concluded that the Sendai virus-induced IF synthesis in CML leucocytes requires de novo protein synthesis.

Adult↗
PubMed1975

Effects of lymphocytotoxins of systemic lupus erythematosus (SLE) sera on T and B lymphocytes.

SLE lymphocytotoxins can be demonstrated on the lymphocytes by immunofluorescence. Complement addition lyses the cells covered with LCT. The proportion of B and T cells as determined by surface immunoglobulins and spontaneous rosette formation of lymphocytes from healthy donors remains unchanged after LCT and complement treatment. The proportion of B and T cells of SLE lymphocytes was altered after cell lysis. The B cells seemed to be relatively resistant, and the T cells more susceptible, to autologous LCT. Thus the relative decrease in the number of T cells in active SLE may be the consequence of surface bound LCT with its effect on the circulating T cells.

B-Lymphocytes↗
PubMed1975

Detection in serum of antilymphocyte-globulin administered in form of eye-drops.

Rosette inhibition tests indicated that similarly as in previous animal experiments, anti-human lymphocyte horse globulin (AHLG) administered in the form of eye-drops entered the systemic blood circulation in man. In the eye into which the AHLG is administered, it is expected to exert a local immunosuppressive effect.

Adult↗